Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC32830 NVS-PAK1-1 An allosteric inhibitor of PAK1
GC32816 Estramustine phosphate sodium
雌莫司汀磷酸钠
A derivative of estradiol that destabilizes microtubules
GC32810 DM4
N2'-去乙酰基-N2'-(4-巯基-4-甲基-1-氧代戊基)-美登素
A derivative of maytansine
GC32785 ML327 ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis.
GC32753 Taltobulin (HTI-286)
N,BETA,BETA-三甲基-L-苯基丙氨酰基-N-[(1S,2E)-3-羧基-1-(1-甲基乙基)-2-丁烯基]-N,3-二甲基-L-缬氨酰胺,HTI-286; SPA-110
An inhibitor of microtubule polymerization
GC32751 Centrinone-B (LCR-323)
LCR-323
Centrinone-B (LCR-323) (LCR-323) 是一种有效且高度选择性的 PLK4 抑制剂，Ki 为 0.59 nM。
GC32743 Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate)
Phen-DC3 Triflate
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
GC32692 APTO-253 (LOR-253)
LOR-253; LT-253
APTO-253 是一种新型小分子，通过诱导 Kruppel 样因子 4 (KLF4) 主转录因子基因表达，从而抑制细胞周期并导致程序性细胞死亡，发挥强大的抗肿瘤活性。
GC32688 Centrinone (LCR-263)
LCR-263
A Plk4 inhibitor
GC32551 Ombrabulin (AC-7700)
奥瑞布林,AVE8062; AC7700
Ombrabulin (AC-7700) (AVE8062) 是 CA-4 磷酸盐的衍生物，已知其通过选择性破坏内皮细胞的微管蛋白细胞骨架而表现出抗血管作用。
GC32448 Thymosin beta 4 (Thymosin β4)
胸腺素beta4
胸腺素 β4 是细胞中主要的肌动蛋白螯合蛋白，可与 G-肌动蛋白相互作用。
GC32186 Puromycin (CL13900)
嘌呤霉素二盐酸盐水合物

Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
GC32134 Parbendazole (SKF 29044)
帕苯咪唑,SKF 29044
An inhibitor of microtubule assembly
GC31952 ROCK-IN-1
ROCK-IN-1是一种有效的ROCK抑制剂，能够抑制ROCK2的活性，IC50值为1.2nM。
GC31883 ROCK2-IN-2 ROCK2-IN-2是一种选择性ROCK2抑制剂，IC50<1μM。详细信息请参考专利文献US20180093978A1中的化合物A-30。
GC31803 Litronesib (LY-2523355)
(-)-N-[4-(2,2-二甲基丙酰基)-5-[[2-(乙基氨基)乙磺酰胺]甲基]-5-苯基-4,5-二氢-1,3,4-噻二唑-2-基]-2,2-二甲基丙酰胺,LY2523355
Litronesib (LY-2523355) (LY2523355) 是一种选择性有丝分裂特异性驱动蛋白 Eg5 抑制剂，具有抗肿瘤活性。
GC30801 PE859 PE859是tau和Aβ积累的有效抑制剂，IC50值分别为0.66和1.2μM。
GC30393 Litronesib Racemate (LY-2523355 Racemate)
LY2523355 Racemate
Litronesib 消旋体 (LY-2523355 Racemate) (LY2523355 Racemate) 是 litronesib 的消旋体。
GC19468 AZD1390 AZD1390是一种新型选择性共济失调毛细血管扩张突变激酶抑制剂，能够高效穿透血脑屏障。
GC19466 Eltanexor (KPT-8602) Eltanexor (KPT-8602)是一种口服有效的输出蛋白-1（XPO1）抑制剂（EC₅₀ = 60.9nM）。
GC19306 RAD51 Inhibitor B02
B02
RAD51 Inhibitor B02是一种人RAD51重组酶的特异性抑制剂（IC₅₀值为27.4μM），对大肠杆菌中的同系物RecA没有抑制作用（IC₅₀>250μM）。
GC19244 Mertansine
美登素,DM1; Maytansinoid DM1
Mertansine是一种强效微管靶向化合物，可抑制微管蛋白组装形成微管，K_D值为0.86µM。
GC19213 Eltanexor Z-isomer
KPT-8602 (Z-isomer)
Eltanexor Z-异构体（KPT-8602 Z-异构体）是 KPT-8602 活性较低的异构体。
GC19177 GSK180736A A ROCK1 and GRK2 inhibitor
GC19112 Crolibulin
EPC2407
Crolibulin (EPC2407) 是一种微管蛋白聚合抑制剂，具有有效的细胞凋亡诱导和细胞生长抑制作用。 Crolibulin 具有抗肿瘤活性。克罗利布林还具有心血管毒性和神经毒性。
GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
GC19058 BAY1217389 An orally bioavailable inhibitor of Mps1
GC19047 AZ32 An ATM kinase inhibitor
GC19034 AR-13324 mesylate
奈他地尔二甲磺酸盐
AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂，已被证明可在低浓度下诱导培养的人和猪 TM 细胞发生形态学变化。
GC19010 Endosidin 2
ES2
Endosidin 2是一种选择性抑制剂，靶向保守的外囊复合体亚基EXO70。
GC18956 AZ82 An inhibitor of KIFC1
GC18909 KRIBB3 An Hsp7 and inhibitor of microtubule polymerization
GC18852 S14161
8-乙氧基-2-(4-氟苯基)-3-硝基-2H-1-苯并吡喃
An inhibitor of cyclin D transactivation
GC18847 RSM-932A
TCD-717

RSM-932A 是一种 ChoKα 抑制剂，对多种肿瘤来源的细胞系具有有效的体外抗增殖活性，对小鼠的人异种移植物具有体内抗肿瘤活性。
GC18763 TN-16
NSC 239274
An inhibitor of microtubule assembly
GC18734 JS-K A nitric oxide donor
GC18727 O-methyl Sterigmatocystin
O-甲基杂色曲霉素
An aflatoxin precursor
GC18726 1-Methyl-1,4-dihydronicotinamide A nicotinamide derivative
GC18720 G-5555 A PAK1 inhibitor
GC18699 JCP174
7-amino-4-chloro-3-Propoxyisocoumarin
An inhibitor of palmitoyl protein thioesterase-1
GC18693 Fascaplysin (chloride)
NSC 622398

A selective Cdk4 inhibitor
GC18666 Debromohymenialdisine
DBH, SKF 108753
An inhibitor of Chk1 and Chk2
GC18616 MMP-8 Inhibitor I
Matrix Metalloproteinase-8 Inhibitor I
MMP-8 Inhibitor I是一种强效的基质金属蛋白酶-8（MMP-8）抑制剂，但口服生物利用度较低。
GC18578 YK-3-237 An inhibitor of tubulin polymerization and activator of SIRT1
GC18565 Suc-AAP-Abu-pNA
Elastase Colorimetric Substrate IV
A substrate for pancreatic elastase
GC18539 4-Hydroxyretinoic acid (4-HRA)
维甲酸杂质
4-Hydroxyretinoic acid (4-HRA)是一种天然存在的，由全反式视黄酸（ATRA）经细胞色素P450酶代谢生成的主要代谢产物。
GC18522 Phosphatidylserines (sodium salt)
L-α-磷脂酰丝氨酸（钠盐）,L-α-Phosphatidylserine
A mixture of phosphatidylserines isolated from soy
GC18452 3,4-Dichloroisocoumarin
3,4-DCI

A serine protease inhibitor
GC18449 Cardanol monoene
腰果酚(C15:1),Cardanol C15
An inhibitor of tyrosinase with anticancer properties
GC18445 N-Deacetylcolchicine
NSC 201400
An inhibitor of microtubule polymerization