Cell Cycle/Checkpoint
Cell Cycle/Checkpoint(细胞周期/检查点)
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more
- ATM/ATR(29)
- Aurora Kinase(58)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(27)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(12)
- Haspin(6)
- HMTase(1)
- Kinesin(27)
- Ksp(4)
- Microtubule/Tubulin(257)
- Mps1(15)
- Mitotic(7)
- RAD51(13)
- ROCK(74)
- Rho(13)
- PERK(11)
- PLK(43)
- PTEN(6)
- Wee1(9)
- PAK(25)
- Arp2/3 Complex(8)
- Dynamin(14)
- ECM & Adhesion Molecules(54)
- Cytoskeleton & Motor Proteins(65)
- Endomembrane System & Vesicular Trafficking(36)
- G1(51)
- Genotoxic Stress(23)
- G2/M(40)
- G2/S(17)
- Inositol Phosphates(67)
- Proteolysis(183)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(1)
- MARK(3)
- NEKs(1)
Cell Cycle/Checkpoint 相关产品(1379)
- GC38898CCG-222740CAS: 1922098-69-8纯度: >99.50%
CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
- GC39156AMG PERK 44CAS: 1883548-84-2纯度: >99.00%
AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。
- GC39177Valecobulin hydrochlorideCAS: 1240321-53-2纯度: >98.50%
Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂 (VDA), 是一种强效的、β-微管蛋白聚合抑制剂，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
- GC39209LCH-7749944CAS: 796888-12-5纯度: >99.00%
LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.
- GC39486DCLK1-IN-1CAS: 2222635-15-4纯度: >98.00%
DCLK1-IN-1是DCLK1和DCLK2的高选择性抑制剂，在KINOMEscan结合试验中对DCLK1和DCLK2的IC 50 分别为9.5nM和31nM。在ATP激酶实验中的IC 50 分别为57nM和103nM。
- GC39558Tubulin inhibitor 6CAS: 105925-39-1纯度: >99.50%
An inhibitor of tubulin polymerization and a PP2A activator
- GC39798ScoulerineCAS: 6451-73-6纯度: >99.00%
A benzylisoquinoline alkaloid with diverse biological activities
- GC39810CID44216842CAS: 1222513-26-9纯度: >99.50%
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.
- GC40085Pazopanib-d6CAS: 1219592-01-4纯度: >99.00%
An internal standard for the quantification of pazopanib
- GC40094all-trans Retinoic Acid-d5纯度: >99.00%
An internal standard for the quantification of all-trans retinoic acid
- GC40118Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)纯度: >95.00%
An inhibitor of caspase-8 and granzyme B
- GC40120Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt)纯度: >95.00%
A fluorogenic substrate for caspase-4
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38898 | CCG-222740 | 1922098-69-8 | >99.50% | |
CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression. | ||||
| GC38945 | S516 | 1016543-77-3 | >98.00% | |
S516 (Compound 22) 是 CKD-516 的活性代谢产物，是一种有效的微管蛋白聚合抑制剂，其 IC50 值为 4.29 μM。S516 具有显著的抗肿瘤活性。 | ||||
| GC39156 | AMG PERK 44 | 1883548-84-2 | >99.00% | |
AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。 | ||||
| GC39177 | Valecobulin hydrochloride | 1240321-53-2 | >98.50% | |
Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂 (VDA), 是一种强效的、β-微管蛋白聚合抑制剂，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。 | ||||
| GC39209 | LCH-7749944 | 796888-12-5 | >99.00% | |
LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4. | ||||
| GC39483 | BO-264 | 2408648-20-2 | >99.50% | |
A TACC3 inhibitor | ||||
| GC39486 | DCLK1-IN-1 | 2222635-15-4 | >98.00% | |
DCLK1-IN-1是DCLK1和DCLK2的高选择性抑制剂，在KINOMEscan结合试验中对DCLK1和DCLK2的IC 50 分别为9.5nM和31nM。在ATP激酶实验中的IC 50 分别为57nM和103nM。 | ||||
| GC39558 | Tubulin inhibitor 6 | 105925-39-1 | >99.50% | |
An inhibitor of tubulin polymerization and a PP2A activator | ||||
| GC39798 | Scoulerine | 6451-73-6 | >99.00% | |
A benzylisoquinoline alkaloid with diverse biological activities | ||||
| GC39810 | CID44216842 | 1222513-26-9 | >99.50% | |
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively. | ||||
| GC40009 | Bostrycin | 21879-81-2 | >95.00% | |
An anthraquinone with diverse biological activities | ||||
| GC40016 | Ganglioside GM2 Mixture (sodium salt) | 19600-01-2 | >98.00% | |
A mixture of ganglioside G M2 | ||||
| GC40021 | LysoFP-NO2 | 69408-75-9 | >98.00% | |
A turn-on fluorescent probe for carbon monoxide | ||||
| GC40036 | MHAPC-Chol | 1027801-74-6 | >95.00% | |
A cationic cholesterol | ||||
| GC40044 | Zymostenol | 566-97-2 | >95.00% | |
A precursor of cholesterol | ||||
| GC40048 | MPS1/TTK Inhibitor | 1202055-39-7 | >98.00% | |
An inhibitor of Mps1/TTK | ||||
| GC40060 | Blasticidin A | 100513-53-9 | >95.00% | |
A bacterial metabolite | ||||
| GC40085 | Pazopanib-d6 | 1219592-01-4 | >99.00% | |
An internal standard for the quantification of pazopanib | ||||
| GC40094 | all-trans Retinoic Acid-d5 | - | >99.00% | |
An internal standard for the quantification of all-trans retinoic acid | ||||
| GC40118 | Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of caspase-8 and granzyme B | ||||
| GC40119 | Z-YVADLD-FMK (trifluoroacetate salt) | - | >95.00% | |
A peptide | ||||
| GC40120 | Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt) | - | >95.00% | |
A fluorogenic substrate for caspase-4 | ||||
| GC40121 | (Z-DEVD)2-Rh 110 (trifluoroacetate salt) | - | >95.00% | |
A fluorogenic substrate for caspase-3 | ||||
| GC40122 | Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt) | - | >95.00% | |
A caspase-3 inhibitor | ||||