Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC44732 Protopine (hydrochloride)

盐酸前鸦片碱
An alkaloid with diverse biological activities
GC73424 PRT062607 acetate

P505-15 acetate; PRT-2607 acetate; BIIB-057 acetate
PRT062607 acetate是一种口服Syk抑制剂（IC50: 1 nM），可抑制炎症和诱导细胞凋亡。
GC49914 Pt(II)-NHC Complex 2C

Platinum(II)-N-Heterocyclic Carbene Complex 2C
An inducer of immunogenic cancer cell death
GC69776 PT-262 PT-262 是一种有效的 ROCK 抑制剂，IC50 值约为 5 μM。PT-262 诱导线粒体膜电位的丧失并提高 caspase-3 的激活和细胞凋亡。PT-262 通过 p53 独立途径抑制 ERK 和 CDC2 磷酸化。PT-262 阻断细胞骨架功能和细胞迁移。PT-262 具有抗癌活性。
GC44740 PtdIns-(1,2-dioctanoyl) (sodium salt)

DOPI, Phosphatidylinositol C8
A synthetic phosphatidylinositol for signal transduction research
GC48008 PtdIns-(1-palmitoyl-d9, 2-palmitoyl) (sodium salt)

DPPI-d9, PI(16:0-d9/16:0), 16:0-d9/16:0 PI
A neuropeptide with diverse biological activities
GC44743 PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

DOPI3P1, Phosphatidylinositol3monophosphate C8
A synthetic phosphatidylinostiol for signal transduction research
GC44744 PtdIns-(3)-P1 (1,2-dipalmitoyl) (ammonium salt)

DPPI3P1
An inositol phospholipid with possible roles in signal transduction
GC48009 PtdIns-(3)-P1 (1,2-dipalmitoyl)-d62 (ammonium salt)

DPPI3Pd62, Phosphatidylinositol3phosphate C16d62
A neuropeptide with diverse biological activities
GC44746 PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)

DOPI3,4P2, Phosphatidylinositol3,4bisphosphate C8
A synthetic phosphatidylinostiol for signal transduction research
GC44747 PtdIns-(3,4)-P2 (1,2-dipalmitoyl) (sodium salt)

DPPI3,4P2, Phosphatidylinositol3,4diphosphate C16
A synthetic analog of natural PtdIns
GC44748 PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

DHPI-3,4,5-P3, Phosphatidylinositol-3,4,5-triphosphate C-6, PIP3C-16
Analog of PIP₃ containing saturated C₆ fatty acid chains
GC44749 PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)

DOPI3,4,5P3, Phosphatidylinositol3,4,5trisphosphate
A synthetic phosphatidylinositol for signal transduction research
GC44750 PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

DPPI3,4,5P3, Phosphatidylinositol3,4,5triphosphate C16
A synthetic analog of natural PtdIns
GC48010 PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt)

DPPI3,4,5P3d62, Phosphatidylinositol3,4,5trisphosphate C16d62
A neuropeptide with diverse biological activities
GC44751 PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)

PI(3,4,5)P3, PI(P-18:0/20:4), PIP33,4,5(18:0/20:4), Phosphatidylinositol3,4,5triphosphate C18 (sodium salt)
An inositol phospholipid with possible roles in signal transduction
GC44753 PtdIns-(3,4,5)-P3-biotin (sodium salt)

Phosphatidylinositol3,4,5triphosphate C8biotin, PIP3biotin
An affinity probe for PI kinases, phosphatases and PIP-binding proteins
GC48011 PtdIns-(3,4,5)-P3-fluorescein (triethylammonium salt) A neuropeptide with diverse biological activities
GC44756 PtdIns-(3,5)-P2 (1,2-dioctanoyl) (sodium salt)

DOPI3,5P2, Phosphatidylinositol3,5bisphosphate C8
A synthetic phosphatidylinositol for signal transduction research
GC44757 PtdIns-(3,5)-P2 (1,2-dipalmitoyl) (sodium salt)

Phosphatidylinositol3,5diphosphate C16
A synthetic phosphatidylinostiol for signal transduction research
GC44758 PtdIns-(4)-P1 (1,2-dihexanoyl) (sodium salt)

DHPI4P1, Phosphatidylinositol4phosphate C6
A synthetic phosphatidylinositol for signal transduction research
GC44759 PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

DOPI4P1, Phosphatidylinositol4phosphate C8
A synthetic phosphatidylinositol for signal transduction research
GC44761 PtdIns-(4)-P1 (1,2-dipalmitoyl) (ammonium salt)

DPPI4P1
A phospholipid with roles in cell signaling
GC44762 PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)

DHPI4,5P2, Phosphatidylinositol4,5bisphosphate C6
A synthetic phosphatidylinositol for signal transduction research
GC44763 PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)

DOPI4,5P2, Phosphatidylinositol4,5bisphosphate C8
A phosphatidylinositol
GC44764 PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (ammonium salt)

DPPI4,5P2, Phosphatidylinositol4,5diphosphate C16
A membrane phospholipid
GC44765 PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt)

DPPI4,5P2, Phosphatidylinositol4,5diphosphate C16
A synthetic phosphatidylinositol for signal transduction research
GC92090 PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)

DPPI-4,5-P₂-d₆₂; Phosphatidylinositol-4,5-diphosphate C₁₆-d₆₂; PI(4,5)P₂ (16:0/16:0)-d₆₂; PIP2[4',5'](16:0/16:0)-d₆₂
PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)旨在用作通过GC或LC质谱定量PtdIns-4,5-P2 1,2-二棕榈酰钠盐的内标。
GC44766 PtdIns-(4,5)-P2 (1,2-dipamitoyl)-d62 (sodium salt)

DPPI4,5P2d62, Phosphatidylinositol4,5diphosphate C16d62
An internal standard for the quantification of PtdIns-(4,5)-P₂ (1,2-dipamitoyl) (sodium salt)
GC44767 PtdIns-(4,5)-P2-biotin (sodium salt)

Phosphatidylinositol4,5diphosphate C8biotin
An affinity probe for PI3-kinases and PIP-binding proteins
GC48012 PtdIns-(4,5)-P2-fluorescein (triethylammonium salt) A neuropeptide with diverse biological activities
GC44770 PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)

DOPI5P1, Phosphatidylinositol5phosphate C8
A synthetic phosphatidylinositol for signal transduction research
GC44771 PtdIns-(5)-P1 (1,2-dipalmitoyl) (ammonium salt)

DPPI5P1
A membrane phospholipid important for cellular signaling
GC60311 PTUPB PTUPB是一种新型的COX-2和sEH双抑制剂，IC₅₀ 值分别为 1.26 nM 和 0.9μM。
GC52484 Purified Ganglioside Mixture (bovine) (ammonium salt) A mixture of purified bovine gangliosides
GC32186 Puromycin (CL13900)

嘌呤霉素二盐酸盐水合物

Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
GC14707 Purvalanol A

NG-60
A selective inhibitor of cyclin-dependent kinases
GC16268 Purvalanol B

(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇,NG 95; NG95; NG-95
A CDK inhibitor
GC72926 PVZB1194 PVZB1194是一种激酶纺锤体蛋白Eg5或KIF11的联苯型抑制剂。
GC45552 Pyrenophorol A fungal metabolite with diverse biological activities
GC15162 Pyridostatin

4-(2-氨基乙氧基)-N2,N6-二[4-(2-氨基乙氧基)-2-喹啉基]-2,6-吡啶二甲酰胺,RR-82;RR82;RR 82
Pyridostatin是一种高选择性的 G-quadruplex DNA 稳定剂 (Kd=490 nM),而不考虑序列可变性。
GC48016 Pyridostatin (trifluoroacetate salt)

RR82 TFA
Pyridostatin (trifluoroacetate salt)是一种高选择性的g -四重体结合小分子，设计用于靶向多态g -四重体结构，而不考虑序列可变性。
GC37043 Pyridostatin hydrochloride

RR82 hydrochloride
Pyridostatin hydrochloride 是一种 G-quadruplexe 稳定剂，Kd 值为 490 nM。
GC17801 PYZD-4409 PYZD-4409 是泛素激活酶 UBA1 的特异性抑制剂，IC50 为 20 μM（无细胞酶测定）。 PYZD-4409 在恶性细胞中诱导细胞死亡并优先抑制原发性急性髓细胞白血病细胞的克隆形成。
GC52057 QN523 An anticancer agent
GC45903 Quazinone

快嗪酮
A PDE3 inhibitor
GC48019 Quercetin (hydrate)

槲皮素二水合物
A flavonoid with diverse biological activities
GC48020 Quercetin-d3 (hydrate) A neuropeptide with diverse biological activities
GC46210 Quinacrine mustard (hydrochloride)

氮芥喹丫因
A fluorescent DNA-intercalating agent
GC44800 Quininib A CysLT₁ and CysLT₂ receptor antagonist