Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
Verubulin hydrochloride is the hydrochloride of compound Verubulin. Verubulin(MPC-6827) is a potent inhibitors of cancer cell growth, with GI50 values of 3-6 nM in T47D, HCT116 and SNU-398 cells.[2]
Verubulin(MPC-6827) has excellent blood brain barrier penetration, and is highly efficacious in a MX-1 breast tumor model. [2]
[1] Chamberlain MC, et al. J Neurooncol. 2014 Jun;118(2):335-343. [1] Sirisoma N, et al. J Med Chem. 2009 Apr 23;52(8):2341-51.