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Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

研究方向

Neuroscience 相关产品(3932)

  • GC39237 structure
    GC39237Perospirone
    CAS: 150915-41-6
    纯度: >99.50%

    Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.

  • GC39248 structure
    GC39248Afoxolaner
    CAS: 1093861-60-9
    纯度: >99.50%

    An isoxazoline insecticide and acaricide

  • GC39254 structure
    GC39254Anatabine dicitrate
    纯度: >99.00%

    Anatabine dicitrate 是一种烟草生物碱，可以穿过血脑屏障。Anatabine dicitrate 是一种有效的 α4β2 nAChR 激动剂。Anatabine dicitrate 通过阻止淀粉样蛋白前体蛋白的 β 裂解，抑制 NF-κB 激活，并降低淀粉样 β (Aβ) 的产生。Anatabine dicitrate 具有抗炎作用，可用于神经退行性疾病的研究。

  • GC39256 structure
    GC39256LP-935509
    CAS: 1454555-29-3
    纯度: >99.50%

    LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM)，一种 ATP 竞争性抑制剂，其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。

  • GC39277 structure
    GC39277Nemifitide diTFA
    CAS: 204992-09-6
    纯度: >99.00%

    Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。

  • GC39293 structure
    GC39293ICA-27243
    CAS: 325457-89-4
    纯度: >99.00%

    ICA-27243, a selective activator of the neuronal M current and KCNQ2/Q3 channels, induces a concentration-dependent increase in a 86Rb+ efflux from CHO cells expressing KCNQ2/Q3 channels with EC50 of 0.2 μM.

  • GC39307 structure
    GC393074-Methylamino antipyrine
    CAS: 519-98-2
    纯度: >98.00%

    An active metabolite of metamizole

  • GC39342 structure
    GC39342AZD7325
    CAS: 942437-37-8
    纯度: >98.50%

    A positive allosteric modulator of α 2 - and α 3 subunit-containing GABA A receptors

  • GC39344 structure
    GC39344BAY-1797
    CAS: 2055602-83-8
    纯度: >98.50%

    A P2X 4 receptor antagonist

  • GC39378 structure
    GC39378Emedastine
    CAS: 87233-61-2
    纯度: >98.00%

    A histamine H 1 receptor antagonist

  • GC39379 structure
    GC39379Fesoterodine
    CAS: 286930-02-7

    A muscarinic acetylcholine receptor antagonist

  • GC39380 structure
    GC39380Fesoterodine L-mandelate
    CAS: 1206695-46-6
    纯度: >98.50%

    Fesoterodine L-mandelate 是一种用于膀胱过度活动症 (OAB) 的有效抗毒蕈碱剂 (antimuscarinic)。

  • GC39419 structure
    GC39419PBD-150
    CAS: 790663-33-1
    纯度: >98.00%

    A glutaminyl cyclase inhibitor

  • GC39424 structure
    GC39424Propofol
    CAS: 2078-54-8
    纯度: >99.50%

    Propofol是一种广泛用于麻醉诱导和维持的静脉麻醉药，具有调节自噬、抗肿瘤或致癌活性。

  • GC39479 structure
    GC39479Bepotastine
    CAS: 125602-71-3
    纯度: >98.00%

    Bepotastine是一种非镇静的、具有口服活性的第二代组胺H1受体（histamine H1 receptor）拮抗剂，其作用选择性高于H3受体、α1、α2和β肾上腺素能受体、多巴胺D2受体、血清素5-HT2受体、乙酰胆碱迷走神经受体以及苯二氮䓬受体。

  • GC39481 structure
    GC39481BL-918
    CAS: 2101517-69-3
    纯度: >98.00%

    An ULK1 activator

  • GC39496 structure
    GC39496Melitracen hydrochloride
    CAS: 10563-70-9
    纯度: >97.00%

    Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.

  • GC39507 structure
    GC39507SEP-363856 hydrochloride
    CAS: 1310422-41-3
    纯度: >98.00%

    SEP-363856 hydrochloride （SEP-856 hydrochloride）是具有口服活性的、中枢神经系统活性的抗精神病活性化合物，具有治疗精神分裂症的潜能。

  • GC39509 structure
    GC39509Substance P TFA
    CAS: 148470-19-3
    纯度: >99.50%

    An endogenous NK 1 receptor agonist

  • GC39534 structure
    GC39534Isoxicam
    CAS: 34552-84-6
    纯度: >98.00%

    Isoxicam 是一种口服有效的非甾体抗炎剂，可用于关节炎的研究。Isoxicam 是一种非选择性的 COX-1 和 COX-2 抑制剂。

  • GC39554 structure
    GC39554AT2 receptor agonist C21
    CAS: 477775-14-7
    纯度: >99.00%

    An AT 2 receptor agonist

  • GC39583 structure
    GC39583Nimesulide D5
    CAS: 1330180-22-7

    An internal standard for the quantification of nimesulide

  • GC39603 structure
    GC39603Methylene blue trihydrate
    CAS: 7220-79-3
    纯度: >99.00%

    Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) 是一种鸟苷酸环化酶 (sGC)，单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue trihydrate 是一种血管加压药，在医疗中通常用作染料。Methylene blue trihydrate 具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。

  • GC39656 structure
    GC39656Pralidoxime iodide
    CAS: 94-63-3
    纯度: >98.00%

    Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.