Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively).1 In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.2
1.Ney, P., Pandita, R.K., Newgreen, D.T., et al.Pharmacological characterization of a novel investigational antimuscarinic drug, fesoterodine, in vitro and in vivoBJU Int.101(8)1036-1042(2008) 2.Biardeau, X., Przydacz, M., Aharony, S., et al.Early fesoterodine fumarate administration prevents neurogenic detrusor overactivity in a spinal cord transected rat modelPLoS One12(1)e0169694(2017)