GLPBio

Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

研究方向

Neuroscience 相关产品(3932)

  • GC38433 structure
    GC38433Jatrorrhizine
    CAS: 3621-38-3

    An alkaloid with diverse biological activities

  • GC38450 structure
    GC38450LML134
    CAS: 1542135-76-1
    纯度: >99.50%

    LML134 (化合物 18b) 是一种具有口服活性，高选择性 H3R (组胺 3 受体) 反向激动剂，对 hH3R 的 cAMP 和 bdg 的 Kis 分别为 0.3 nM 和 12 nM。LML134 快速穿透大脑，导致高 H3R 占有率，并以快速的动力学特征使其目标脱离。LML134 用于治疗过度睡眠障碍。

  • GC38489 structure
    GC38489(1α,1'S,4β)-Lanabecestat
    CAS: 1384082-96-5

    (1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) 是一种 BACE1 抑制剂，IC50 分别为 2.2 nM (TR-FRET 测定) 和 0.28 nM (sAPPp 释放测定)，详细信息请参考专利文献 WO2012087237A1 中的化合物 20a。

  • GC38509 structure
    GC38509Masupirdine mesylate
    CAS: 1791396-46-7

    Masupirdine mesylate (SUVN-502 mesylate) 是一种有效的，选择性的，具有口服生物可利用且可穿透脑屏障的 5-HT6 受体拮抗剂 (对人 5-HT6 受体的 Ki 为 2.04 nM)。Masupirdine mesylate (SUVN-502 mesylate) 对 5-HT2A 受体和其他 100个 靶点显示高选择性，有治疗阿尔茨海默病的潜力。

  • GC38529 structure
    GC38529Geissoschizine methyl ether
    CAS: 60314-89-8
    纯度: >98.00%

    Geissoschizine methyl ether，一种 Uncaria hook 发现的生物碱类化合物，也是具有精神药物作用的 Yokukansan 的主要活性成分。Geissoschizine methyl ether 是有效的 5-HT1A 受体的激动剂。

  • GC38558 structure
    GC38558PF-03654746 Tosylate
    CAS: 1039399-17-1
    纯度: >99.50%

    PF-03654746 Tosylate (PF-03654746) 是一种有效的选择性组胺 H3 receptor 拮抗剂，具有脑渗透性。PF-03654746 Tosylate (PF-03654746) 可减少过敏原引起的鼻炎反应。PF-03654746 Tosylate (PF-03654746) 用于治疗人类认知障碍，改善阿尔茨海默病人 (AD) 的认知。

  • GC38583 structure
    GC38583PXS-5153A monohydrochloride
    纯度: >99.50%

    PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3 (LOXL2/LOXL3) 的双抑制剂，对几乎所有哺乳动物LOXL2的IC50 均< 40 nM，对人类LOXL3 的IC50 为63 nM。PXS-5153A monohydrochloride 可减少交联，改善纤维化。

  • GC38616 structure
    GC38616Hamaudol
    CAS: 735-46-6

    Hamaudol 是从 Saposhnikovia divaricata 中分离出的一种色酮。Hamaudol 对环加氧酶 (COX)-1 和 COX-2 的活性具有明显的抑制能力，其 IC50 值分别为 0.30、0.57 mM，并且具有有效的镇痛和抗炎作用。

  • GC38625 structure
    GC38625Dehydronuciferine
    CAS: 7630-74-2
    纯度: >98.50%

    Dehydronuciferine 从 Nelumbo nucifera Gaertn 的叶子中分离，是一种乙酰胆碱酯酶 (AChE) 抑制剂，其 IC50 为 25 μg/mL。

  • GC38628 structure
    GC38628Licochalcone B
    CAS: 58749-23-8
    纯度: >99.50%

    Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

  • GC38657 structure
    GC38657Meclofenamate sodium
    CAS: 6385-02-0
    纯度: >99.50%

    A competitive inhibitor of COX- 1 and - 2

  • GC38658 structure
    GC38658Oxotremorine M iodide
    CAS: 3854-04-4

    Oxotremorine M iodide 是一种有效的，选择性毒蕈碱型乙酰胆碱受体 (mAChR) 激动剂。Oxotremorine M iodide 通过毒蕈碱受体依赖和独立机制增强 NMDA 受体。

  • GC38677 structure
    GC38677 (-)-α-Pinene
    CAS: 7785-26-4
    纯度: >98.00%

    (-)-α-Pinene 是一种单萜类化合物，通过在 BZD 结合位点作为部分调节剂与 GABAA-苯二氮卓 (BZD) 受体直接结合，显示出增强睡眠的特性。

  • GC38678 structure
    GC38678Ethyl Caffeate
    CAS: 102-37-4
    纯度: >98.50%

    Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.

  • GC38693 structure
    GC38693Choline bitartrate
    CAS: 87-67-2
    纯度: >99.00%

    Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.

  • GC38698 structure
    GC386981-Naphthyl acetate
    CAS: 830-81-9
    纯度: >99.50%

    1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.

  • GC38732 structure
    GC38732Acotiamide monohydrochloride trihydrate
    CAS: 773092-05-0
    纯度: >99.00%

    Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.

  • GC38746 structure
    GC38746CCK-B Receptor Antagonist 2
    CAS: 155412-88-7
    纯度: >98.50%

    CCK-B Receptor Antagonist 2，化合物 15b，是有效的口服活性 Gastrin/CCK-B 拮抗剂，IC50 值为 0.43 nM。 CCK-B Receptor Antagonist 2 还抑制 Gastrin/CCK-A 活性，IC50 为 1.82 μM。

  • GC38753 structure
    GC38753cis-Urocanic acid
    CAS: 7699-35-6
    纯度: >99.50%

    cis-Urocanic acid 是一种 5-HT2A 受体激动剂。cis-Urocanic acid 以较高亲和力与 5-HT 受体结合，Kd 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂，通过与 5-HT2A 受体结合而诱导免疫抑制。

  • GC38758 structure
    GC38758Clomethiazole
    CAS: 533-45-9
    纯度: >98.00%

    Chlormethiazole 是一种有效的口服 GABAA 激动剂。 Chlormethiazole 还可以抑制人肝微粒体中的细胞色素 P450 亚型: CYP2A6 和 CYP2E1。Chlormethiazole 有抗惊厥作用，具有治疗惊厥性癫痫的潜力。

  • GC38760 structure
    GC38760Cyamemazine
    CAS: 3546-03-0
    纯度: >99.00%

    Cyamemazine 是一种抗精神病药，其中含有吩噻嗪发色团，通常被用作抗焦虑药。Cyamemazine 是具有抗精神病活性的有效的 5-HT3 (Ki 为 12 nM), 5-HT2A (Ki 为 1.5 nM) 和 5-HT2C (Ki 为 75 nM) 受体拮抗剂。

  • GC38781 structure
    GC38781Frovatriptan succinate hydrate
    CAS: 158930-17-7
    纯度: >99.00%

    An agonist of 5-HT 1B and 5-HT 1D receptors

  • GC38793 structure
    GC38793Huperzine B
    CAS: 103548-82-9

    An alkaloid with neuroprotective activity

  • GC38805 structure
    GC38805L-745870
    CAS: 158985-00-3

    L-745870 is a high-affinity, selective and orally active antagonist of human dopamine D4 receptor with Ki of 0.43 nM. L-745870 considerably weaker D2 and D3 receptors affinity with Ki of 960 nM and 2300 nM, respectively. L-745870 has excellent brain penetration.