GlpBio

CCK-B Receptor Antagonist 2

目录号: GC38746纯度: >98.50%
CCK-B Receptor Antagonist 2，化合物 15b，是有效的口服活性 Gastrin/CCK-B 拮抗剂，IC50 值为 0.43 nM。 CCK-B Receptor Antagonist 2 还抑制 Gastrin/CCK-A 活性，IC50 为 1.82 μM。
CCK-B Receptor Antagonist 2
Cas No.: 155412-88-7
规格价格库存数量操作
5mg¥4,050.00现货
1
10mg¥6,750.00现货
1
50mg¥20,250.00现货
1
100mg¥30,150.00现货
1
200mg询价现货
1
500mg询价现货
1
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文献被引

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产品描述 Description

CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].

CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1].

[1]. Semple G, et al. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40(3):331-41.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
155412-88-7
SMILES
O=C(N[C@H]1C(N(CC(C(C)(C)C)=O)C2=CC=CC=C2C(C3=NC=CC=C3)=N1)=O)NC4=CC=CC(N)=C4
分子式
C27H28N6O3
分子量
484.55 g/mol
溶解性
DMSO: 250 mg/mL (515.94 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol