GlpBio

CCMI

目录号: GC12119纯度: >99.50%同义词: AVL-3288; UCI-4083
CCMI (AVL-3288) 是一种有效且选择性的 α7 nAChR 阳性变构调节剂，不通过正构位点结合或激活 α7 nAChRs，并导致激动剂诱导的 α7 nAChRs 电流显着正向调节。
CCMI
Cas No.: 917837-54-8
规格价格库存数量操作
5mg¥558.00现货
1
10mg¥900.00现货
1
25mg¥1,710.00现货
1
50mg¥2,700.00现货
1
100mg¥4,365.00现货
1
10mM (in 1mL DMSO)¥477.00现货
1
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文献被引

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    31, 1291–1307 (2021)

产品描述 Description

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

References:
[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
917837-54-8
同义词
AVL-3288; UCI-4083
化学名
(Z)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide
SMILES
ClC1=CC=C(C=C1)NC(/C(C2=CC(C)=NO2)=C\NC(C=C3)=CC=C3Cl)=O
分子式
C19H15Cl2N3O2
分子量
388.25 g/mol
溶解性
<38.83mg/ml in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol