GlpBio

(1R,2R)-2-PCCA(hydrochloride)

目录号: GC30855纯度: >98.00%
(1R,2R)-2-PCCAhydrochloride是一种有效的GPR88受体激动剂，EC50值为3nM。
(1R,2R)-2-PCCA(hydrochloride)
Cas No.: 1609563-71-4
规格价格库存数量操作
1mg¥810.00现货
1
5mg¥1,620.00现货
1
10mg¥3,150.00现货
1
10mM (in 1mL DMSO)¥1,881.00现货
1
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产品描述 Description

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM.

(1R,2R)-2-PCCA hydrochloride is a potent GPR88 receptor agonist, with an EC50 of 3 nM[1]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].

[1]. Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1. [2]. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1609563-71-4
SMILES
CCCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)CC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl
分子式
C30H39Cl2N3O
分子量
528.56 g/mol
溶解性
DMSO : 50 mg/mL (94.60 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol