Neuroscience
Neuroscience(神经科学)
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more
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Neuroscience 相关产品(3932)
- GC91355Chlorphenesin CarbamateCAS: 886-74-8纯度: >98.00%
氯苯甲酸甲酯是一种肌肉松弛剂。在浓度为1毫摩尔时，它可以降低电流刺激腹根引起的背根电位以及L-谷氨酸诱导的孤立青蛙脊髓运动神经元放电。
- GC91375Promethazine SulfoxideCAS: 7640-51-9纯度: >95.00%
盐酸普罗米嗪是组胺H1受体拮抗剂普罗米嗪的代谢产物。它由细胞色素P450（CYP）同工酶CYP2D6将普罗米嗪转化而成。
- GC91406UK 122 (trifluoroacetate salt)CAS: 1186653-73-5纯度: >95.00%
UK 122是一种尿激酶型纤溶酶原激活剂（uPA）抑制剂（IC50 = 0.2 uM）。它选择性地作用于uPA，而不影响组织型纤溶酶原激活剂（tPA）、胰蛋白酶、纤溶酶和凝血酶（所有的IC50均大于100uM）。
- GC91417Ipsapirone (hydrochloride)CAS: 92589-98-5纯度: >98.00%
伊普沙匹隆是一种5-羟色胺（5-HT）受体5-HT1A的部分激动剂（在海马膜中Ki = 10 nM）。它可以减少大鼠腹侧海马体内的5-HT释放。
- GC91438N-ethyl PerfluorooctanesulfonamidoethanolCAS: 1691-99-2纯度: >90.00%
N-乙基全氟辛烷磺酰胺乙醇（N-ethyl FOSE）是一种全氟烷基物质（PFAS）。
- GC91472Tat-Gap 19 (trifluoroacetate salt)纯度: >95.00%
Tat-Gap 19是一种连接蛋白43（Cx43）半通道的肽抑制剂。它由HIV-1 Tat蛋白转导域和与Cx43残基128-136相对应的九个氨基酸肽链组成。
- GC91480Exendin-4 (3-39) amide (trifluoroacetate salt)纯度: >90.00%
Exendin-4 (3-39)酰胺是一种糖肽样肽1受体（GLP-1R）激动剂，也是exendin-4 (48-86)酰胺的活性代谢物。
- GC91492Propiverine N-oxideCAS: 111071-96-6纯度: >95.00%
Propiverine N-oxide is an active metabolite of the muscarinic acetylcholine receptor antagonist propiverine .
- GC91493Semaglutide Side ChainCAS: 1118767-16-0纯度: >98.00%
Semaglutide side chain is a synthetic intermediate.
- GC91497EB 47 (hydrochloride)CAS: 1190332-25-2纯度: >98.00%
EB 47 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 45 nM) and a dual site inhibitor of tankyrase 2 (TNKS2; IC50 = 45 nM).
- GC91544Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OHCAS: 1662688-20-1纯度: >99.50%
Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH is a building block in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide .
- GC916804-Acetamido AntipyrineCAS: 83-15-8纯度: >95.00%
4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole .
- GC91681Loxoprofen-SRSCAS: 83648-76-4纯度: >98.00%
Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen .
- GC91690TASP0277308CAS: 945725-50-8纯度: >98.00%
TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).
- GC91703AL 34662 (formate)纯度: >98.00%
AL 34662 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2.
- GC91849Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt)纯度: >95.00%
Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC91298 | (±)-Linalool-d3 | 1216673-02-7 | >99.00% | |
一种用于量化(±)-芳樟醇的内部标准。 | ||||
| GC91355 | Chlorphenesin Carbamate | 886-74-8 | >98.00% | |
氯苯甲酸甲酯是一种肌肉松弛剂。在浓度为1毫摩尔时，它可以降低电流刺激腹根引起的背根电位以及L-谷氨酸诱导的孤立青蛙脊髓运动神经元放电。 | ||||
| GC91375 | Promethazine Sulfoxide | 7640-51-9 | >95.00% | |
盐酸普罗米嗪是组胺H1受体拮抗剂普罗米嗪的代谢产物。它由细胞色素P450（CYP）同工酶CYP2D6将普罗米嗪转化而成。 | ||||
| GC91406 | UK 122 (trifluoroacetate salt) | 1186653-73-5 | >95.00% | |
UK 122是一种尿激酶型纤溶酶原激活剂（uPA）抑制剂（IC50 = 0.2 uM）。它选择性地作用于uPA，而不影响组织型纤溶酶原激活剂（tPA）、胰蛋白酶、纤溶酶和凝血酶（所有的IC50均大于100uM）。 | ||||
| GC91417 | Ipsapirone (hydrochloride) | 92589-98-5 | >98.00% | |
伊普沙匹隆是一种5-羟色胺（5-HT）受体5-HT1A的部分激动剂（在海马膜中Ki = 10 nM）。它可以减少大鼠腹侧海马体内的5-HT释放。 | ||||
| GC91438 | N-ethyl Perfluorooctanesulfonamidoethanol | 1691-99-2 | >90.00% | |
N-乙基全氟辛烷磺酰胺乙醇（N-ethyl FOSE）是一种全氟烷基物质（PFAS）。 | ||||
| GC91449 | Ipamorelin (acetate) | - | >98.00% | |
Ipamorelin是一种五肽生长激素分泌素（GHS）和GHS受体1a（GHS-R1a）激动剂。 | ||||
| GC91472 | Tat-Gap 19 (trifluoroacetate salt) | - | >95.00% | |
Tat-Gap 19是一种连接蛋白43（Cx43）半通道的肽抑制剂。它由HIV-1 Tat蛋白转导域和与Cx43残基128-136相对应的九个氨基酸肽链组成。 | ||||
| GC91480 | Exendin-4 (3-39) amide (trifluoroacetate salt) | - | >90.00% | |
Exendin-4 (3-39)酰胺是一种糖肽样肽1受体（GLP-1R）激动剂，也是exendin-4 (48-86)酰胺的活性代谢物。 | ||||
| GC91488 | Proxymetacaine (hydrochloride) | 5875-06-9 | >98.00% | |
Proxymetacaine is an anesthetic. | ||||
| GC91492 | Propiverine N-oxide | 111071-96-6 | >95.00% | |
Propiverine N-oxide is an active metabolite of the muscarinic acetylcholine receptor antagonist propiverine . | ||||
| GC91493 | Semaglutide Side Chain | 1118767-16-0 | >98.00% | |
Semaglutide side chain is a synthetic intermediate. | ||||
| GC91497 | EB 47 (hydrochloride) | 1190332-25-2 | >98.00% | |
EB 47 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 45 nM) and a dual site inhibitor of tankyrase 2 (TNKS2; IC50 = 45 nM). | ||||
| GC91507 | CP 93,129 | 127792-75-0 | >95.00% | |
CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B. | ||||
| GC91544 | Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH | 1662688-20-1 | >99.50% | |
Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH is a building block in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide . | ||||
| GC91621 | WLB-89462 | 2849471-75-4 | >98.00% | |
WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor). | ||||
| GC91680 | 4-Acetamido Antipyrine | 83-15-8 | >95.00% | |
4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole . | ||||
| GC91681 | Loxoprofen-SRS | 83648-76-4 | >98.00% | |
Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen . | ||||
| GC91690 | TASP0277308 | 945725-50-8 | >98.00% | |
TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM). | ||||
| GC91703 | AL 34662 (formate) | - | >98.00% | |
AL 34662 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2. | ||||
| GC91849 | Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) | - | >95.00% | |
Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase. | ||||
| GC91887 | Methyl Salicylate-d4 | 1219802-12-6 | >99.00% | |
Methyl Salicylate-d4用于GC-或LC-MS定量水杨酸甲酯的内部标准。 | ||||
| GC91889 | L-Tyrosine (sodium salt hydrate) | - | >98.00% | |
L-Tyrosine (sodium salt hydrate)是一种条件必需氨基酸。 | ||||
| GC91899 | Carmustine-d8 | - | >99.00% | |
Carmustine-d8旨在用作气相色谱或液相色谱-质谱定量卡莫司汀的内标。 | ||||