Semaglutide side chain is a synthetic intermediate.[1] It has been used as an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide , as well as a lipid side chain to increase the proteolysis-resistance of insulin derivatives for use in vivo.[1],[2]
References:
[1].Guryanov, I., Orlandin, A., De Paola, I., et al.Copper(II) lysinate and pseudoproline assistance in the convergent synthesis of the GLP 1 receptor agonists liraglutide and semaglutideOrg. Process Res. Dev.25(7)1598-1611(2021).
[2].Kjeldsen, T.B., Hubálek, F., Tagmose, T.M., et al.Engineering of orally available, ultralong-acting insulin analogues: Discovery of OI338 and OI320.J. Med. Chem.64(1)616-628(2021).