Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC45548Photoswitchable PAD Inhibitor (technical grade)CAS: 2226393-62-8纯度: >70.00%
A photoactivated PAD inhibitor
- GC45640TP-238 (hydrochloride)CAS: 2415263-05-5纯度: >99.00%
A chemical probe for the bromodomains of CECR2 and BPTF
- GC45763Tolcapone-d4CAS: 1246816-93-2纯度: >99.00%
An internal standard for the quantification of tolcapone
- GC46104Butyric Acid-d7CAS: 73607-83-7纯度: >98.00%
An internal standard for the quantification of sodium butyrate
- GC46148Filgotinib-d4CAS: 2041095-50-3纯度: >99.00%
An internal standard for the quantification of filgotinib
- GC46159Histone H2AX (134-143) (human) (trifluoroacetate salt)纯度: >95.00%
A neuropeptide with diverse biological activities
- GC46191Oclacitinib-13C-d3CAS: 2750534-84-8纯度: >99.00%
A neuropeptide with diverse biological activities
- GC465032-(1,8-Naphthyridin-2-yl)phenol (2-NP)CAS: 65182-56-1纯度: >99.50% / >98.00%
An enhancer of STAT1 activity
- GC466074-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneCAS: 64091-91-4纯度: >98.00%
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone是一种主要存在于烟草制品中的强效烟草特异性致癌物，对α7烟碱型乙酰胆碱受体（α7 nAChR）具有很高的亲和力，在小细胞肺癌（SCLCs）中的EC 50 值为0.03μM，在肺神经内分泌细胞（PNECs）中的EC 50 值为0.005μM。
- GC466284-Chloro-6,7-bis(2-methoxyethoxy)quinazolineCAS: 183322-18-1纯度: >95.00%
A building block and synthetic intermediate
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC45548 | Photoswitchable PAD Inhibitor (technical grade) | 2226393-62-8 | >70.00% | |
A photoactivated PAD inhibitor | ||||
| GC45609 | ZLD1039 | 1826865-46-6 | >98.00% | |
An inhibitor of EZH2 | ||||
| GC45640 | TP-238 (hydrochloride) | 2415263-05-5 | >99.00% | |
A chemical probe for the bromodomains of CECR2 and BPTF | ||||
| GC45717 | Chlamydocin | 53342-16-8 | >70.00% | |
An HDAC inhibitor | ||||
| GC45763 | Tolcapone-d4 | 1246816-93-2 | >99.00% | |
An internal standard for the quantification of tolcapone | ||||
| GC45772 | 6(5H)-Phenanthridinone | 1015-89-0 | >98.00% | |
An inhibitor of PARP1 and 2 | ||||
| GC45808 | OUL35 | 6336-34-1 | >99.00% | |
An inhibitor of PARP10 | ||||
| GC45906 | MC1742 | 1776116-74-5 | >98.00% | |
An inhibitor of class I and class IIb HDACs | ||||
| GC45908 | (R)-BAY-598 | 1906920-28-2 | >98.00% | |
An inhibitor of SMYD2 | ||||
| GC45927 | DS-437 | 1674364-87-4 | >98.00% | |
A dual inhibitor of PRMT5 and PRMT7 | ||||
| GC46081 | A-395 (hydrochloride) | - | >98.00% | |
A neuropeptide with diverse biological activities | ||||
| GC46104 | Butyric Acid-d7 | 73607-83-7 | >98.00% | |
An internal standard for the quantification of sodium butyrate | ||||
| GC46148 | Filgotinib-d4 | 2041095-50-3 | >99.00% | |
An internal standard for the quantification of filgotinib | ||||
| GC46152 | GS-441524 | 1191237-69-0 | >98.00% | |
An antiviral nucleoside analog | ||||
| GC46159 | Histone H2AX (134-143) (human) (trifluoroacetate salt) | - | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC46191 | Oclacitinib-13C-d3 | 2750534-84-8 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC46213 | Ro 41-0960 | 125628-97-9 | >98.00% | |
A COMT inhibitor | ||||
| GC46226 | SS-208 | 2245942-72-5 | >98.00% | |
An HDAC6 inhibitor | ||||
| GC46503 | 2-(1,8-Naphthyridin-2-yl)phenol (2-NP) | 65182-56-1 | >99.50% / >98.00% | |
An enhancer of STAT1 activity | ||||
| GC46508 | 2',2'-Difluoro-2'-deoxyuridine | 114248-23-6 | >95.00% | |
An active metabolite of gemcitabine | ||||
| GC46607 | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone | 64091-91-4 | >98.00% | |
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone是一种主要存在于烟草制品中的强效烟草特异性致癌物，对α7烟碱型乙酰胆碱受体（α7 nAChR）具有很高的亲和力，在小细胞肺癌（SCLCs）中的EC 50 值为0.03μM，在肺神经内分泌细胞（PNECs）中的EC 50 值为0.005μM。 | ||||
| GC46628 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | 183322-18-1 | >95.00% | |
A building block and synthetic intermediate | ||||
| GC46675 | 4-Phenyl-2-pyrrolidinone | 1198-97-6 | >98.00% | |
A precursor and synthetic intermediate | ||||
| GC46736 | 7-Bromoheptanoic Acid | 30515-28-7 | >95.00% | |
A building block | ||||