Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC11823 LY2835219 free base

阿贝西利,CDK4/6 dual inhibitor;LY 2835219 (free base);LY-2835219 (free base)
LY2835219 free base是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC₅₀ 分别为 2nM 和 10nM。
GC11971 LY2857785 A Cdk9 inhibitor
GC33057 LY3295668 (AK-01)

AK-01
LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.
GC44100 LysoFP-NH2 The fluorescent form of lysoFP-NO₂
GC40021 LysoFP-NO2 A turn-on fluorescent probe for carbon monoxide
GC52358 Malachite Green (chloride)

Basic Green 4, C.I. 4200, C.I. 42000
A triphenylmethane dye
GC41186 Malformin C

畸形素C
A natural bicyclic pentapeptide
GC61400 MAP4343 MAP4343是Pregnenolone的3-甲基醚衍生物。MAP4343在体外与微管相关蛋白2(MAP2)结合，刺激微管蛋白的聚合，增强神经突的延伸并保护神经元免受神经毒性剂的侵害。
GC73537 MARK4 inhibitor 2 MARK4 inhibitor 2是微管亲和调节激酶4（MARK4）的抑制剂，Km为6.3×10^7，IC50为0.82μM。
GC73538 MARK4 inhibitor 3 MARK4 inhibitor 3（化合物23b）是MAPK4的抑制剂，IC50值为1.01μM。
GC62205 Maytansine

美坦新,NSC 153858
An ansa macrolide with anticancer activity
GC32895 Maytansinol (Ansamitocin P-0)

美登醇,Ansamitocin P-0
An ansa macrolide
GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor
GC73531 MC-EVCit-PAB-MMAE MC-EVCit-PAB-MMAE (Linker-Payload 11)是ADC的药物连接物偶联物。
GC36560 Mc-MMAD Mc-MMAD 由高效微管抑制剂 MMAD 与保护基团 maleimidocaproyl 偶联而成。Mc-MMAD 可用于偶联抗体。
GC36561 Mc-MMAE

马来酰亚胺基己酰-单甲基澳瑞他汀E,Maleimidocaproyl-monomethylauristatin E
Mc-MMAE 是保护基团 (马来酰亚氨基己酰) 共轭连接到 MMAE。Mc-MMAE 是有效的微管蛋白抑制剂，可用于偶联抗体。
GC73869 MC-Val-Cit-PAB-Ispinesib MC-Val-Cit-PAB-Ispinesib（化合物509）是Eg5的强效抑制剂。
GC18363 Mca-DEVDAPK(Dnp)-OH

Caspase-3 Fluorogenic Substrate III, CPP32 Fluorogenic Substrate III, 7-Methoxycoumarin-4-acetyl-DEVDAPK(Dnp)-OH, Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH
A caspase-3 fluorogenic substrate
GC90559 Mca-KPLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt)

Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl), FS-6

一种MMPs的荧光底物
GC40120 Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt)

Mca-Leu-Glu-Val-Asp-Gly-Trp-Lys(Dnp)-NH2
A fluorogenic substrate for caspase-4
GC47605 Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2 (trifluoroacetate salt)

Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(DNP)-NH2
A neuropeptide with diverse biological activities
GC44133 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 (trifluoroacetate salt)

Matrix Metalloproteinase-2 Fluorogenic Substrate, Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2, MMP-2 Fluorogenic Substrate
A fluorogenic substrate for MMP-2
GC44132 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

Matrix Metalloproteinase-14 Fluorogenic Substrate I, Mca-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH2, MMP-14 Fluorogenic Substrate I
A fluorogenic substrate for MMP-14
GC44134 Mca-PLGL-Dpa-AR-NH2 (trifluoroacetate salt)

Matrix Metalloproteinase-2/Matrix Metalloproteinase-7 Fluorogenic Substrate, Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, MMP-2/MMP-7 Fluorogenic Substrate
A fluorogenic substrate for MMP-2 and MMP-7
GC90538 Mca-RPPGFSAFK(Dnp)-OH (trifluoroacetate salt)

(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)-OH

一种用于ECE-1的荧光底物
GC44135 Mca-VDQMDGW-K(Dnp)-NH2 (ammonium salt)

Caspase-3 Fluorogenic Substrate V
A caspase-3 fluorogenic substrate
GC47607 Mca-YVADAP-K(Dnp)-OH (trifluoroacetate salt)

Caspase-1 Fluorogenic Substrate V, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH, Mca-YVADAP-Lys(Dnp)-OH, (7-Methoxycoumarin-4-yl)acetyl-YVADAPK(2,4-dinitrophenyl)-OH
A neuropeptide with diverse biological activities
GC34068 McMMAF (Maleimidocaproyl monomethylauristatin F)

Maleimidocaproyl monomethylauristatin F
McMMAF (Maleimidocaproyl monomethylauristatin F) 是一种保护基团缀合的 MMAF。 MMAF 是一种有效的微管蛋白聚合抑制剂。
GC73299 MDEG-541 MDEG-541是一种强效的MYC-MAX降解剂。
GC10200 Mdivi 1

3-(2,4-二氯-5-甲氧基苯基)-2,3-二氢-2-硫代-4(1H)-喹唑啉酮,Mitochondrial division inhibitor 1
Mdivi-1（线粒体分裂抑制剂 1）抑制创伤性脑损伤 (TBI) 诱导的动力蛋白相关蛋白 1 (Drp1) 上调、自噬功能障碍和线粒体自噬激活。
GC17649 Mebendazole

甲苯咪唑
A broad-spectrum anthelmintic that inhibits microtubules
GC47619 Menaquinone 4-d7

甲萘醌 4-d7
An internal standard for the quantification of menaquinone 4
GC19244 Mertansine

美登素,DM1; Maytansinoid DM1
An anticancer agent
GC16607 Mesalamine

5-氨基水杨酸; Mesalamine; 5-ASA; Mesalazine
An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine
GC61043 Mesalamine impurity P

美沙拉嗪EP杂质P
MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
GC49065 Metacetamol

N-(3-羟基苯基)乙酰胺
A derivative of acetaminophen
GC47645 Methidathion

杀扑磷
An organophosphate insecticide
GC47646 Methiocarb

甲硫威
A carbamate pesticide
GC47660 Methyl Parathion

甲基对硫磷
An organophosphate insecticide
GC90682 Methyl Parathion-d6
一种甲基对硫磷定量的内部标准
GC44181 Methylcarbamyl PAF C-8 C-8 analog of Methylcarbamyl PAF C-16
GC40036 MHAPC-Chol A cationic cholesterol
GC36608 Microtubule inhibitor 1 Microtubule inhibitor 1 是一种抗癌药物，能够抑制微管聚合，其在肿瘤细胞中的IC50 为 9-16 nM。
GC13491 Mirin

(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮
Mirin是一种Mre11-Rad50-Nbs1（MRN）复合物抑制剂（IC₅₀=12μM），能够抑制Mre11相关的外切酶活性，Mirin可抑制MRN依赖的ATM的激活。通常用于与DNA修复机制相关的癌症的研究。
GC44200 Mitomycin A

丝裂霉素A
A bacterial metabolite
GC74159 MK-0731 MK-0731是一种选择性、非竞争性和变构驱动蛋白纺锤体蛋白（KSP）抑制剂，IC50为2.2 nM，pKa为7.6。
GC16030 MK-1775

MK1775,MK 1775
MK-1775 是一种有效的选择性 Wee1 激酶小分子抑制剂，IC50 值为 5.2 nM。
GC61072 MK-28 MK-28是有效、选择性的PERK激动剂。MK-28在小鼠中表现出良好的药代动力学特征，且能透过血脑屏障。
GC17162 MK-5108 (VX-689)

VX-689
A potent inhibitor of Aurora kinases
GC10442 MK-8745 An Aurora A kinase inhibitor