GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC33269 structure
    GC33269Valecobulin (CKD-516)
    CAS: 1188371-47-2
    纯度: >98.00%

    Valecobulin (CKD-516) (CKD516) 是 (S516) 的缬氨酸前药和血管破坏剂 (VDA)。 Valecobulin (CKD-516) 是一种有效的 β-tubulin 聚合抑制剂，对小鼠和人类实体瘤具有显着的抗肿瘤活性。

  • GC33291 structure
    GC33291Tubulin inhibitor 1
    CAS: 2237054-53-2
    纯度: >99.50%

    Tubulininhibitor1是tubulin抑制剂，靶作用于秋水仙素结合位点，抑制微管蛋白聚集。Tubulininhibitor1具有抗肿瘤活性，能够导致细胞G2/M期有丝分裂停滞，诱导细胞凋亡。

  • GC33300 structure
    GC33300CCB02
    CAS: 2100864-57-9
    纯度: >99.50%

    CCB02是一种选择性的CPAP-tubulin相互作用抑制剂，能够与tubulin结合，竞争β-tubulin的CPAP结合位点，IC50值为689nM，具有高效抗肿瘤活性。CCB02对其他的蛋白没有抑制作用，包括与细胞周期、中心体相关蛋白，同时对AuroraA，Plk1，Plk2，CDK2和CHK1的磷酸化状态无作用。

  • GC33310 structure
    GC33310Rho-Kinase-IN-1
    CAS: 1035094-83-7
    纯度: >99.50%

    Rho-Kinase-IN-1是一个rho激酶抑制剂，来自专利US20090325960A1，化合物1.008。

  • GC33362 structure
    GC33362Amuvatinib hydrochloride (MP470 hydrochloride)
    CAS: 1055986-67-8

    A multi-targeted RTK inhibitor

  • GC33370 structure
    GC33370Amphethinile (Amphetinile)
    CAS: 91531-98-5

    Amphetinile (Amphetinile) 是一种抗微管蛋白剂。 Amphetinile (Amphetinile) 与微管蛋白结合的亲和常数 (Ka) 为 1.3 μM。

  • GC33377 structure
    GC33377KSI-3716
    CAS: 1151813-61-4
    纯度: >98.50%

    KSI-3716是c-Myc的抑制剂。

  • GC33379 structure
    GC33379Aurora B inhibitor 1
    CAS: 937276-52-3

    AuroraBinhibitor1是一种AuroraB(Aurora-1)抑制剂，Ki值<0.010uM。详细信息请参考专利文献WO2007059299A1中的化合物1-3。

  • GC33404 structure
    GC33404KU 59403
    CAS: 845932-30-1
    纯度: >98.50%

    KU59403是ATM的一个有效抑制剂，其IC50值为3nM。

  • GC33420 structure
    GC33420BAY-1895344
    CAS: 1876467-74-1
    纯度: >99.50%

    An ATR inhibitor

  • GC33421 structure
    GC33421PAK-IN-1
    CAS: 1394121-05-1
    纯度: >99.00%

    A group 2 PAK inhibitor

  • GC33901 structure
    GC33901Pentanoic acid
    CAS: 109-52-4
    纯度: >99.00%

    Pentanoicacid是一种短链脂肪酸，是细菌代谢产物，与过敏性皮肤病有关系。Pentanoicacid能够激活ROCK信号通路。

  • GC34022 structure
    GC34022Ombrabulin hydrochloride (AVE8062)
    CAS: 253426-24-3
    纯度: >99.50%

    A tubulin polymerization inhibitor and tumor vascular disrupting agent

  • GC34068 structure
    GC34068McMMAF (Maleimidocaproyl monomethylauristatin F)
    CAS: 863971-19-1
    纯度: >99.50%

    McMMAF (Maleimidocaproyl monomethylauristatin F) 是一种保护基团缀合的 MMAF。 MMAF 是一种有效的微管蛋白聚合抑制剂。

  • GC34073 structure
    GC34073Empesertib (BAY 1161909)
    CAS: 1443763-60-7
    纯度: >98.00%

    Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.

  • GC34094 structure
    GC34094Mycro 3
    CAS: 944547-46-0
    纯度: >99.00%

    Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.

  • GC34102 structure
    GC34102BNC105
    CAS: 945771-74-4
    纯度: >98.50%

    An inhibitor of tubulin polymerization

  • GC34109 structure
    GC34109Tirbanibulin Mesylate (KX2-391 (Mesylate))
    CAS: 1080645-95-9
    纯度: >99.50%

    A Src kinase inhibitor

  • GC34135 structure
    GC34135Taltobulin trifluoroacetate (HTI-286 trifluoroacetate)
    CAS: 228266-41-9
    纯度: >99.50%

    An inhibitor of microtubule polymerization

  • GC34159 structure
    GC34159Ilorasertib (ABT-348)
    CAS: 1227939-82-3

    A multi-kinase inhibitor

  • GC34297 structure
    GC34297PF-2771
    CAS: 2070009-55-9
    纯度: >99.50%

    PF-2771是一种选择性的着丝粒蛋白E(CENP-E)抑制剂，IC50值为16.1nM，具有抗肿瘤活性。

  • GC34300 structure
    GC34300AR-13324 analog mesylate
    CAS: 2095432-73-6

    AR-13324类似物甲磺酸盐是AR-13324的类似物。

  • GC34303 structure
    GC34303Taltobulin hydrochloride (HTI-286 hydrochloride)

    An inhibitor of microtubule polymerization

  • GC34374 structure
    GC34374BAY-1895344 hydrochloride

    An ATR inhibitor