GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC32830 structure
    GC32830NVS-PAK1-1
    CAS: 1783816-74-9
    纯度: >99.00%

    An allosteric inhibitor of PAK1

  • GC32846 structure
    GC32846BOS-172722
    CAS: 1578245-44-9
    纯度: >99.00%

    BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.

  • GC32853 structure
    GC32853PD0166285
    CAS: 185039-89-8
    纯度: >99.00%

    PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.

  • GC32868 structure
    GC32868BDP5290
    CAS: 1817698-21-7
    纯度: >98.50%

    BDP5290对MRCKβ、ROCK1、ROCK2的IC50值分别为17nM、230nM、123nM和100nM，是ROCK和MRCK的有效抑制剂。

  • GC32890 structure
    GC32890Cytochalasin B (Phomin)
    CAS: 14930-96-2
    纯度: {{1-3}>99.00% / {4-13}>98.00%} / {14}>99.50%}

    Cytochalasin B(细胞松弛素B)是一种可渗透细胞的真菌毒素,从Phoma属的子囊菌真菌中分离得到。

  • GC32895 structure
    GC32895Maytansinol (Ansamitocin P-0)
    CAS: 57103-68-1
    纯度: >99.00%

    An ansa macrolide

  • GC32912 structure
    GC32912IBR2
    CAS: 313526-24-8
    纯度: >97.00%

    IBR2是一种特异性RAD51抑制剂。

  • GC32935 structure
    GC32935Soblidotin (Auristatin PE)
    CAS: 149606-27-9
    纯度: >99.50%

    Soblidotin (Auristatin PE) (Auristatin PE) 是一种新型合成的 Dolastatin 10 衍生物和微管蛋白聚合抑制剂。

  • GC32969 structure
    GC32969Dimethylenastron
    CAS: 863774-58-7
    纯度: >98.00%

    An inhibitor of EG5

  • GC33002 structure
    GC33002PBOX 6
    CAS: 290814-68-5
    纯度: >99.50%

    PBOX6是一种pyrrolo-1,5-benzoxazepine(PBOX)化合物，可作为微管解聚剂和促凋亡剂起作用。

  • GC33006 structure
    GC33006CCT020312
    CAS: 324759-76-4
    纯度: >98.50% / >98.00%

    CCT020312是一种选择性蛋白激酶R样内质网激酶（PERK）通路激动剂。

  • GC33057 structure
    GC33057LY3295668 (AK-01)
    CAS: 1919888-06-4
    纯度: >98.00%

    LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.

  • GC33074 structure
    GC33074SSE15206
    CAS: 1370046-40-4
    纯度: >98.00%

    SSE15206是一种微管(microtubule)聚合抑制剂，其在HCT116细胞SRB增殖实验中的GI50值为197nM。

  • GC33086 structure
    GC33086LDN-192960
    CAS: 184582-62-5
    纯度: >99.50%

    An inhibitor of haspin and DYRK2

  • GC33120 structure
    GC33120ZINC00881524
    CAS: 557782-81-7
    纯度: >99.00%

    A ROCK inhibitor

  • GC33125 structure
    GC33125Entasobulin
    CAS: 501921-61-5
    纯度: >98.00%

    Entasobulin是具有潜在抗癌活性的β-微管蛋白聚合抑制剂。

  • GC33136 structure
    GC33136PF-06380101
    CAS: 1436391-86-4
    纯度: >99.00%

    PF-06380101是Dolastatin10新型类似物，具有强细胞毒性，AMDE特性与其他auristatin类似物不同，ADCs中毒素分子。

  • GC33149 structure
    GC33149BTB-1
    CAS: 86030-08-2
    纯度: >99.50%

    A reversible Kif18A inhibitor

  • GC33155 structure
    GC33155Tubulysin A (TubA)
    CAS: 205304-86-5

    Tubulysin A (TubA)(TubA) 是一种粘细菌产品，可在许多体外试验中用作抗血管生成剂；抗微管、抗有丝分裂、凋亡诱导剂、抗癌、抗血管生成和抗增殖。

  • GC33163 structure
    GC33163OSIP-486823 (OSIP 486823)
    CAS: 200803-37-8
    纯度: >98.00%

    OSIP-486823 (OSIP 486823) 是一种新型微管干扰剂，对蛋白激酶 G (PKG) 和微管具有独特的生物学效应。

  • GC33169 structure
    GC33169Rosabulin (STA 5312)
    CAS: 501948-05-6
    纯度: >98.50%

    Rosabulin (STA 5312) (STA 5312) 是一种有效且具有口服活性的微管抑制剂，可抑制微管组装。 Rosabulin (STA 5312) 具有广谱抗肿瘤活性。

  • GC33175 structure
    GC33175Lexibulin dihydrochloride (CYT-997 dihydrochloride)
    CAS: 917111-49-0

    An inhibitor of microtubule polymerization

  • GC33178 structure
    GC33178Tasidotin hydrochloride (ILX651)
    CAS: 623174-20-9

    Tasidotin hydrochloride (ILX651) 是抗有丝分裂肽 dolastatin 15 的肽类似物，作为微管组装和微管动力学的抑制剂。

  • GC33213 structure
    GC33213CCT251455
    CAS: 1400284-80-1
    纯度: >98.00%

    CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1(MPS1)抑制剂，IC50值为3nM。