Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC12467 KPT-330

塞利尼索
KPT-330（Selinexor）是一种具有口服活性的选择性核输出抑制剂（SINE）化合物，抑制核输出蛋白XPO1（又名CRM1）。
GC14615 KPT-9274 Orally acitve allosteric inhibitor of PAK4
GC18909 KRIBB3 An Hsp7 and inhibitor of microtubule polymerization
GC33377 KSI-3716 KSI-3716是c-Myc的抑制剂。
GC11118 KU 55933

2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮
KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，K_i值为2.2nM。
GC33404 KU 59403
KU59403是ATM的一个有效抑制剂，其IC50值为3nM。
GC12054 KU-60019

KU60019;KU 60019
A potent ATM kinase inhibitor
GC47532 KUS121 A VCP modulator
GC14592 KW 2449

[4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮
A multi-kinase inhibitor
GC72824 KX2-361

KX-02
KX2-361（KX-02）是一种Src激酶和微管蛋白聚合抑制剂。
GC14288 KX2-391

5-[4-[2-(4-吗啉基)乙氧基]苯基]-N-(苯基甲基)-2-吡啶乙酰胺,KX2-391; KX-01
A Src kinase inhibitor
GC10222 KX2-391 dihydrochloride

5-[4-[2-(4-吗啉基)乙氧基]苯基]-N-(苯基甲基)-2-吡啶乙酰胺盐酸盐,KX2-391 2HCl; KX2-391
A Src kinase inhibitor
GC44020 L-681,217 An antibiotic
GC40793 L-erythro Sphinganine (d18:0)

L-苏式-二氢鞘胺醇
A bioactive sphingolipid
GC49547 L-Glutamic Acid γ-p-Nitroanilide (hydrate)

γ-Glu-pNA, Glutamate γ-(4-Nitroanilide), L-GPNA, E-pNA
A colorimetric substrate for γ-glutamyl transpeptidase
GC91028 L-K6L9 (trifluoroacetate salt)
一种细胞溶解肽（即能够破坏细胞的蛋白质分子）。
GC49205 L-Leu-AMC (hydrochloride)

L-亮氨酰7-氨基-4-甲基香豆素盐酸盐,Leu-AMC hydrochloride
A fluorogenic substrate for leucine aminopeptidase
GC44081 L-myo-Inositol-1,4,5-triphosphate (sodium salt)

D-myo-Inositol-3,5,6-triphosphate, Ins(1,4,5)P3, 1,4,5IP3
Isomer of D-myo-inositol-1,4,5-triphosphate
GC47577 L-Ornithine lactam (hydrochloride)

(S)-3-氨基哌啶-2-酮盐酸盐
A synthetic intermediate
GC41520 Lachnone A A fungal metabolite
GC49471 LAMP1 Monoclonal Antibody (Clone Ly1C6) For immunochemical analysis of LAMP1
GC41272 Lateropyrone

Avenacein Y
A fungal metabolite
GC15671 Latrunculin A

红海海绵素A,LAT-A

一种可逆抑制肌动蛋白聚合的药物
GC50052 Laulimalide
Microtubule stabilzing agent
GC50214 LCB 03-0110 dihydrochloride Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
GC39209 LCH-7749944

GNF-PF-2356
LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.
GC17067 LDC000067

(3-(6-(2-甲氧基苯基)嘧啶-4-基氨基)苯基)甲烷磺酰胺,LDC067
A Cdk9 inhibitor
GC33086 LDN-192960

3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
An inhibitor of haspin and DYRK2
GC44047 LDN-192960 (hydrochloride) An inhibitor of haspin and DYRK2
GC10842 LEE011

瑞博西尼; LEE011
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
GC15922 LEE011 hydrochloride

瑞博西尼盐酸盐; LEE011 hydrochloride
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
GC15377 LEE011 succinate

瑞博西尼琥珀酸盐; LEE011 succinate
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
GC49751 Lefamulin

来法莫林,BC-3781
A pleuromutilin antibiotic
GC18345 Leptomycin A

来普霉素A
An inhibitor of nuclear transport
GC10954 Leptomycin B

来普霉素B; CI 940; LMB
Leptomycin B (LMB)是染色体区域维持1 (CRM1)的抑制剂,CRM1是核蛋白输出蛋白之一。
GC33175 Lexibulin dihydrochloride (CYT-997 dihydrochloride)

CYT-997 dihydrochloride
An inhibitor of microtubule polymerization
GC14857 LFM-A13 A BTK inhibitor
GC70857 LIMK-IN-1 LIMK-IN-1（化合物14）是LIM激酶（LIMK）的抑制剂，LIMK1和LIMK2的IC50分别为0.5 nM和0.9 nM。
GC90981 Lipid 10

?EA-PIP

一种可离子化的阳离子脂质
GC69379 Lipid 8 Lipid 8 是一种可电离的氨基脂质，可用于合成脂质纳米颗粒。
GC91124 Lipid III-45

Cationic Lipid A

一种可离子化的阳离子脂质
GC74104 Lisavanbulin dihydrochloride

BAL-101553 dihydrochloride
Lisavanbulin dihydrochloride（BAL-101553）是微管靶向剂Avanbulin（BAL 27862）的前药。
GC31803 Litronesib (LY-2523355)

(-)-N-[4-(2,2-二甲基丙酰基)-5-[[2-(乙基氨基)乙磺酰胺]甲基]-5-苯基-4,5-二氢-1,3,4-噻二唑-2-基]-2,2-二甲基丙酰胺,LY2523355
Litronesib (LY-2523355) (LY2523355) 是一种选择性有丝分裂特异性驱动蛋白 Eg5 抑制剂，具有抗肿瘤活性。
GC30393 Litronesib Racemate (LY-2523355 Racemate)

LY2523355 Racemate
Litronesib 消旋体 (LY-2523355 Racemate) (LY2523355 Racemate) 是 litronesib 的消旋体。
GC61014 Lusianthridin

4,7-二羟基-2-甲氧基-9,10-二氢菲
Lusianthridin是来自Dendrobiumvenustum的天然化合物，具有抗迁移作用。Lusianthridin通过抑制Src-STAT3信号，促进c-Myc的降解。
GC44094 LX7101 (hydrochloride) A LIMK and ROCK inhibitor
GC12402 LX7101 HCL A LIMK and ROCK inhibitor
GC15741 LY2603618

LY2603618; IC-83
A Chk1 inhibitor
GC15663 LY2606368

5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368
LY2606368 是一种 ATP 竞争性 CHK1 抑制剂，目前处于临床阶段，Ki 为 0.9 nM，IC50 <1 nM。
GC16822 LY2835219

Abemaciclib; LY2835219 methanesulfonate
LY2835219 free base是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC₅₀ 分别为 2nM 和 10nM。