GlpBio

BTB-1

目录号: GC33149纯度: >99.50%同义词: 4-氯-2-甲基苯基硫氰酸酯
A reversible Kif18A inhibitor
BTB-1
Cas No.: 86030-08-2
规格价格库存数量操作
1mg¥238.00现货
1
5mg¥495.00现货
1
10mg¥792.00现货
1
25mg¥1,272.00现货
1
50mg¥1,800.00现货
1
100mg¥2,700.00现货
1
10mM (in 1mL DMSO)¥779.00现货
1
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文献被引

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产品描述 Description

BTB-1 is a reversible inhibitor of the kinesin-8 family motor protein Kif18A (IC50 = 1.69 μM).1 It is selective for Kif18A over a panel of seven kinesins at 100 μM. BTB-1 (100 μM) inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay. It induces mitotic accumulation of HeLa cells in a dose-dependent manner.

1.Catarinella, M., Grüner, T., Strittmatter, T., et al.BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18AAngew. Chem. Int. Ed. Engl.48(48)9072-9076(2009)

实验参考方法 Experimental Reference Method

Kinase experiment:

BTB-1 is prepared in DMSO. The activity of His-Kif18Amotor at increasing concentrations of ATP is monitored in the presence of 3 μM Mts and increasing concentrations of BTB-1 (0.21 μM, 0.42 μM, 0.85 μM, 1.7 μM) or DMSO as control[1].

References:

[1]. Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6.
[2]. Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10(2):554-60.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
86030-08-2
同义词
4-氯-2-甲基苯基硫氰酸酯
SMILES
O=S(C1=CC=C(Cl)C=C1[N+]([O-])=O)(C2=CC=CC=C2)=O
分子式
C12H8ClNO4S
分子量
297.71 g/mol
溶解性
DMSO : ≥ 100 mg/mL (335.90 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol