GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC19849 structure
    GC19849SGC3027
    CAS: 2624313-13-7
    纯度: >98.50% / >98.00%

    A prodrug form of SGC8158

  • GC20007 structure
    GC20007Ginsenoside CK
    CAS: 39262-14-1
    纯度: >98.00%

    Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。

  • GC25025 structure
    GC25025Abraxane
    纯度: >99.00% / >98.00%

    Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.

  • GC25075 structure
    GC25075Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)
    CAS: 66584-72-3
    纯度: >99.50%

    Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.

  • GC25372 structure
    GC25372Elimusertib (BAY-1895344) hydrochloride

    Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.

  • GC25482 structure
    GC25482GSK269962A HCl
    CAS: 2095432-71-4

    GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

  • GC25940 structure
    GC25940SNS-314
    CAS: 1057249-41-8

    SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.

  • GC30393 structure
    GC30393Litronesib Racemate (LY-2523355 Racemate)
    CAS: 546111-97-1
    纯度: >99.00%

    Litronesib 消旋体 (LY-2523355 Racemate) (LY2523355 Racemate) 是 litronesib 的消旋体。

  • GC30801 structure
    GC30801PE859
    CAS: 1402727-29-0
    纯度: >99.50%

    PE859是tau和Aβ积累的有效抑制剂，IC50值分别为0.66和1.2μM。

  • GC31803 structure
    GC31803Litronesib (LY-2523355)
    CAS: 910634-41-2
    纯度: >98.50%

    Litronesib (LY-2523355) (LY2523355) 是一种选择性有丝分裂特异性驱动蛋白 Eg5 抑制剂，具有抗肿瘤活性。

  • GC31883 structure
    GC31883ROCK2-IN-2
    CAS: 1995065-79-6

    ROCK2-IN-2是一种选择性ROCK2抑制剂，IC50<1μM。详细信息请参考专利文献US20180093978A1中的化合物A-30。

  • GC31952 structure
    GC31952ROCK-IN-1
    CAS: 934387-35-6

    ROCK-IN-1是一种有效的ROCK抑制剂，能够抑制ROCK2的活性，IC50值为1.2nM。

  • GC32134 structure
    GC32134Parbendazole (SKF 29044)
    CAS: 14255-87-9
    纯度: >99.00%

    An inhibitor of microtubule assembly

  • GC32186 structure
    GC32186Puromycin (CL13900)
    CAS: 53-79-2
    纯度: {{1-12}>98.00%}

    Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • GC32448 structure
    GC32448Thymosin beta 4 (Thymosin &beta;4)
    CAS: 77591-33-4

    胸腺素 β4 是细胞中主要的肌动蛋白螯合蛋白，可与 G-肌动蛋白相互作用。

  • GC32551 structure
    GC32551Ombrabulin (AC-7700)
    CAS: 181816-48-8

    Ombrabulin (AC-7700) (AVE8062) 是 CA-4 磷酸盐的衍生物，已知其通过选择性破坏内皮细胞的微管蛋白细胞骨架而表现出抗血管作用。

  • GC32688 structure
    GC32688Centrinone (LCR-263)
    CAS: 1798871-30-3
    纯度: >98.00%

    A Plk4 inhibitor

  • GC32692 structure
    GC32692APTO-253 (LOR-253)
    CAS: 916151-99-0
    纯度: >98.00%

    APTO-253 是一种新型小分子，通过诱导 Kruppel 样因子 4 (KLF4) 主转录因子基因表达，从而抑制细胞周期并导致程序性细胞死亡，发挥强大的抗肿瘤活性。

  • GC32743 structure
    GC32743Phen-DC3 Trifluoromethanesulfonate (Phen-DC3 Triflate)
    CAS: 929895-45-4
    纯度: >98.5%

    Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.

  • GC32751 structure
    GC32751Centrinone-B (LCR-323)
    CAS: 1798871-31-4
    纯度: >98.50%

    Centrinone-B (LCR-323) (LCR-323) 是一种有效且高度选择性的 PLK4 抑制剂，Ki 为 0.59 nM。

  • GC32753 structure
    GC32753Taltobulin (HTI-286)
    CAS: 228266-40-8
    纯度: >99.50%

    An inhibitor of microtubule polymerization

  • GC32785 structure
    GC32785ML327
    CAS: 1883510-31-3
    纯度: >98.00%

    ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis.

  • GC32810 structure
    GC32810DM4
    CAS: 796073-69-3
    纯度: >98.50%

    A derivative of maytansine

  • GC32816 structure
    GC32816Estramustine phosphate sodium
    CAS: 52205-73-9
    纯度: >98.00%

    A derivative of estradiol that destabilizes microtubules