Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC49687 Goralatide (acetate)

N-Acetyl-Ser-Asp-Lys-Pro, AcSDKP
A tetrapeptide regulator of hematopoiesis
GC48720 Griseofulvic Acid

(±)-Griseofulvic Acid
A metabolite of griseofulvin
GC13484 Griseofulvin

灰黄霉素
A fungal metabolite with antifungal and anticancer activities
GC48688 Griseofulvin-d3

灰黄霉素 d3
An internal standard for the quantification of griseofulvin
GC49744 GRP94 Monoclonal Antibody (Clone 9G10) For immunochemical detection of GRP94
GC38791 GSK-25 GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。
GC15659 GSK-923295

3-氯-N-{(1S)-2-[(N,N-二甲基甘氨酰)氨基]-1-[(4-{8-[(1S)-1-羟基乙基]咪唑并[1,2-A]吡啶-2-基}苯基)甲基]乙基}-4-[(1-甲基乙基)氧基]苯甲酰胺,GSK 923295;GSK923295
An inhibitor of CENP-E
GC10008 GSK1070916

GSK-1070916A
A potent inhibitor of Aurora B and C kinases
GC19177 GSK180736A A ROCK1 and GRK2 inhibitor
GC17450 GSK2606414

GSK 2606414;GSK-2606414
GSK2606414是一种具有口服活性的选择性蛋白激酶R样内质网激酶（PERK）抑制剂，IC₅₀值为0.4nM。
GC11068 GSK2656157 A PERK inhibitor
GC17936 GSK269962A

N-[3-[[2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-C]吡啶-6-基]氧]苯基]-4-[[2-(4-吗啉基)乙基]氧]苯甲酰胺,GSK 269962
A ROCK1 and ROCK2 inhibitor
GC25482 GSK269962A HCl

GSK269962B, GSK269962, GSK 269962
GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
GC18119 GSK429286A

N-(6-氟-1H-吲唑-5-基)-2-甲基-6-氧代-4-[4-(三氟甲基)苯基]-1,4,5,6-四氢-3-吡啶甲酰胺
A ROCK inhibitor
GC12335 GSK461364

GSK461364A
A reversible inhibitor of Plk1
GC49280 GSK579289A A Plk1 inhibitor
GC60891 GW406108X

GW108X
GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
GC11621 GW843682X

3-[2-(三氟甲基)苄氧基]-5-(5,6-二甲氧基-1H-苯并[D]咪唑-1-基)-2-噻吩甲酰胺,GW 843682X;GW843682;GW-843682X
A reversible polo-like kinase inhibitor
GC16545 GX-674 GX-674 是一种有效的、状态依赖性、异构体选择性电压门控钠通道 1.7 (Nav1.7) 拮抗剂，在 -40 mV 时的 IC50 为 0.1 nM。
GC36207 H-1152 A ROCK inhibitor
GC36208 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
GA21951 H-4-Nitro-Phe-OEt . HCl

3-(4-硝基苯基)-L-丙氨酸盐酸盐
A building block
GC49305 H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)

H-RGDC-OH
An RGD-containing tetrapeptide
GA22303 H-D-Pro-Phe-Arg-pNA . 2 HCl

pFR-pNA, Plasma Kallikrein Chromogenic Substrate, D-Pro-Phe-Arg-p-nitroaniline
A colorimetric plasma kallikrein substrate
GC45471 H-Gly-Arg-pNA (hydrochloride)

Gly-Arg-4-NA, GR-pNA, GR p-nitroanilide
A colorimetric thrombin substrate
GC49605 H-Gly-Pro-Hyp-OH (acetate)

H-GP-Hyp-OH, Tripeptide-29
A peptide DPP-4 inhibitor
GC43803 HA-1077 (hydrochloride)

盐酸法舒地尔,HA-1077 dihydrochloride; AT-877 dihydrochloride
A ROCK inhibitor
GC43805 HAPC-Chol A cationic cholesterol
GC49855 Harmalol (hydrochloride hydrate)

骆驼蓬酚盐酸盐(二水)
A β-carboline alkaloid and an active metabolite of harmaline
GC69207 Haspin-IN-3 Haspin-IN-3 (compound 8l) 是一种有效的 haspin 抑制剂，IC50 为 14 nM。Haspin-IN-3 具有抗癌作用。
GC17196 Hesperadin A multi-kinase inhibitor
GC50050 Hesperadin hydrochloride A multi-kinase inhibitor
GC49915 Hexa-D-Arginine (trifluoroacetate salt)

Furin Inhibitor II, Hexa-D-Arg-NH2, Hexa-D-Arginine amide, D6R-NH2, (D)RRRRRR-NH2
A furin inhibitor
GC45639 Hexapeptide-11 (acetate)

FVAPFP, Phe-Val-Ala-Pro-Phe-Pro
A synthetic hexapeptide
GC43827 Histone H3 (1-15) (Phospho-Ser10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

ARTKQTARK-pS-TGGKA, pSer10-Histone H3 (1-15), 1-15 H3pS10, H3S10ph (1-15), H31-15S10ph
A peptide fragment of histone H3
GC43829 Histone H3 (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

ARTKQTARKSTGGKAPRKQL
A peptide fragment of histone H3
GC43830 Histone H3 (21-44) (Phospho-Ser28) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

ATKAARK-pS-APSTGGVKKPHRYRPG, pSer28-Histone H3 (21-44)
A peptide fragment of histone H3
GC43832 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)

ATKAARKSAPSTGGVKKPHRYRPG-GK(Biotin)-NH2, Histone H3 (21-44)
A biotinylated peptide fragment of histone H3
GC43833 Histone H3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)

KAARKSAPATGG
A peptide fragment of histone H3
GC43853 Histone H3K36Me3 (21-44)-GK-biotin (trifluoroacetate salt)

ATKAARKSAPATGGV-K(Me3)-KPHRYRPG-GK(Biotin), Histone H3 (21-44) (Lys36me3), Lys(Me3)36-Histone H3 (21-44)-GK(Biotin)
A biotinylated peptide fragment of histone H3
GC45479 Histone H3K36Me3 (31-41) (trifluoroacetate salt)

Histone H3 (31-41) (Lys36me3), Lys(Me3)36-Histone H3 (31-41), STGGV-K(Me3)-KPHRY
A peptide fragment of histone H3
GC13928 HMN-214

(E)-4-[2-[2-[N-乙酰基-N-[(4-甲氧基苯基)磺酰]氨基]苯基]乙烯基]吡啶1-氧化物,IVX-214
A prodrug form of HMN-176
GC62594 hnRNPK-IN-1 hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体，用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis)，并具有很强的抗肿瘤活性。
GC49742 Hsf1 Monoclonal Antibody (Clone 10H8) For immunochemical analysis of Hsf1
GC47436 HT-2 Toxin-13C22

HT-2毒素-13C22溶液
An internal standard for the quantification of HT-2 toxin
GC91099 HUP-55
一种脯氨酸内切肽酶抑制剂
GC10901 Hydroxyfasudil

羟基法舒地尔; HA-1100
Hydroxyfasudil 是一种 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 IC50 分别为 0.73 和 0.72 μM。
GC10338 Hydroxyfasudil hydrochloride

羟基法舒地尔盐酸盐; HA-1100 hydrochloride; HA 1100 hydrochloride; HA1100 hydrochloride
A ROCK inhibitor
GC32912 IBR2 IBR2是一种特异性RAD51抑制剂。
GC45743 ICAAc

3-amino-6-Isocyanoacridine
A solvatochromic fluorophore and pH probe