Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC12719 Indomethacin heptyl ester A potent, non-selective COX-2 inhibitor
GC15628 bis(7)-Tacrine
1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine
A potent acetylcholinesterase inhibitor
GC16428 Tolmetin (sodium salt hydrate)
痛灭定
A non-selective NSAID
GC12466 FAUC-365 A dopamine D₃ receptor antagonist
GC15723 Dimebolin
2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基吡啶-3-基)乙基]-1H-吡啶并[4,3-B]吲哚,Dimebon?
A neuroprotective agent
GC17007 TAE-1 A sym-triazine with diverse biological activities
GC11989 Nortriptyline (hydrochloride)
盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
A tricyclic antidepressant
GC13786 (±)-Salsolinol (hydrochloride) A metabolite of ethanol that targets dopaminergic neurons
GC11243 Halopemide
卤培米特,NSC 354856,R34301
Inhibitor of phospholipase D₁ and D₂
GC15438 Asoxime (chloride)
HI-6
An AChE reactivator
GC17885 VU0364572 (trifluoroacetate salt) A selective muscarinic M₁ receptor agonist
GC11203 ZLJ-6 Dual inhibitor of cyclooxygenase/5-lipoxygenase
GC11054 Epiallopregnanolone
别孕烷-3Β,21-二醇-20-酮,5α-Pregnan-20-one,3β,21-dihydroxy-5α-Pregnan-20-one,3β,5α-Tetrahydrodeoxycorticosterone,3β,5α-Tetrahydroprogesterone

A neurosteroid
GC12892 Doxepin (hydrochloride)
盐酸多塞平
A tricyclic antidepressant
GC17705 Edrophonium (chloride)
依酚氯铵
An AChE inhibitor
GC14122 Clorgyline (hydrochloride)
盐酸氯吉林
Clorgyline (hydrochloride)是一种不可逆、强效和选择性单胺氧化酶（MAO）A 抑制剂，对MAO-A和MAO-B的K_i值分别为0.054和58μM，IC₅₀值分别为 0.0012和1.9μM。
GC17037 NQTrp
1,4-Naphthoquinon-2-yl-L-tryptophan
An inhibitor of Aβ oligomerization
GC12885 Imipramine (hydrochloride)
盐酸丙咪嗪
A tricyclic antidepressant
GC14323 Pirinixic Acid Aminothiazole A dual inhibitor of mPGES-1 and 5-LO
GC10378 N-Isopropylnoratropine
异丙托品杂质E,NINA
An intermediate in the synthesis of ipratropium
GC12927 (±)-Baclofen
巴氯芬
(±)-Baclofen是γ-氨基丁酸（GABA）的亲脂性衍生物，是一种口服有效，选择性的代谢型GABAB受体激动剂，IC₅₀为200nM。
GC14281 L-DOPA methyl ester (hydrochloride)
盐酸左旋多巴甲酯,3,4-Dihydroxyphenylalanine methyl ester,LDME,Levodopa methyl ester,ST 41769
A dopamine precursor
GC14302 9,12-Octadecadiynoic Acid
Ro 3-1314
An inhibitor of both COX and lipoxygenase
GC15105 FPS-ZM1
RAGE Antagonist
FPS-ZM1是一种特异性RAGE抑制剂，K_i值为25nM。
GC13042 Inotilone
(2E)-2-[(3,4-二羟基苯基)亚甲基]-5-甲基-3(2H)-呋喃酮
A COX-2 inhibitor
GC15758 BQCA
1-(4-甲氧基苄基)-4-氧代-1,4-二氢喹啉-3-羧酸
A positive allosteric modulator of the M₁ mAChR
GC16824 Pargyline (hydrochloride)
优降宁盐酸盐；盐酸帕吉林；巴吉林盐酸盐
An irreversible MAO inhibitor
GC10643 Pimozide
匹莫齐特; R6238
Pimozide是一种化学结构新颖、高效且口服长效的神经阻滞剂类多巴胺受体抑制剂，对多巴胺D2、D3和D4 受体的Ki值分别为2.4nM、0.2nM和1.8nM。
GC13465 Chlorcyclizine (hydrochloride)
盐酸氯环利嗪；盐酸氯环力嗪
A histamine H₁ antagonist
GC11606 4-Methylbenzylidene camphor
4-甲基苄亚基樟脑; 4-MBC; Enzacamene
A UV blocker with estrogenic effects
GC14828 CPHPC
Ro 63-8695|GSK2315698
An inhibitor of the protein-protein interaction between SAP and amyloid fibrils
GC16082 Spinosyn A
多杀霉素 A
A naturally-occurring insecticide
GC14013 Losartan Carboxaldehyde
氯沙坦甲醛,DuP-167|EXP3179
A losartan metabolite with anti-inflammatory actions
GC10231 ZINC12613047
butyrylcholinesterase (BChE) inhibitor
GC13314 L-Acetylcarnitine (hydrochloride)
乙酰左旋肉碱,Acetyl-L-Carnitine,ALCAR
A mitochondrial metabolite
GC17656 Chlorprothixene (hydrochloride)
氯普噻吨盐酸盐；泰尔登盐酸盐；氯丙硫蒽盐酸盐
A dopamine D₂ receptor antagonist
GC11721 Sulindac sulfone
磺基舒林,Exisulind
A metabolite of sulindac
GC15977 (S)-Ketoprofen
(S)-(+)-酮洛芬; (S)-Ketoprofen; Dexketoprofen
A potent inhibitor of COX-1 and COX-2
GC15351 PF-9184 A potent mPGES-1 inhibitor
GC15604 Hydroxytacrine (maleate)
马来酸维吖啶,HP 029,1-Hydroxytacrine,P 83-6029A,Velnacrine
A major active metabolite of tacrine
GC11124 Lanicemine
拉尼西明; AZD6765
A low-trapping NMDA channel blocker
GC11100 Flibanserin
氟立班丝氨; BIMT-17; BIMT-17BS
A 5-HT_1A receptor agonist and 5-HT_2A receptor antagonist
GC15845 Guvacoline (hydrobromide)
氢溴酸胍喹啉,Norarecoline
A muscarinic receptor agonist
GC16782 Benocyclidine
N-[1-(2-苯并[B]噻嗯-2-基)环己基)]哌啶马来酸
An Analytical Reference Standard
GC11098 Verubecestat (MK-8931)
维罗司他; MK-8931
An inhibitor of BACE1 and BACE2
GC12293 Perphenazine
奋乃静
A typical antipsychotic
GC11695 Cinnarizine
桂利嗪
A calcium channel inhibitor and histamine H₄ receptor antagonist
GC12962 Isatin
靛红,Indoline-2,3-dione
Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂，IC50 为 3 μM。
GC13757 CarbinoxaMine Maleate
马来酸罗托沙敏
A histamine H₁ receptor antagonist
GC17596 Netupitant
奈妥吡坦; CID 6451149
An NK₁ receptor antagonist