Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction
GC30844 Afloqualone
氟喹酮; HQ-495
An Analytical Reference Standard
GC30840 Quinagolide hydrochloride (CV205-502 hydrochloride)
盐酸喹高利特; CV205-502 hydrochloride

Quinagolide hydrochloride (CV205-502 hydrochloride) 是一种选择性多巴胺 D2 受体激动剂，也是一种催乳素抑制剂。
GC30839 Traxoprodil
曲索罗地

An antagonist of NR2B subunit-containing NMDA receptors
GC30836 MK-7622 (M1 receptor modulator)
3-[(1S,2S)-2-羟基环己基]-6-[(6-甲基-3-吡啶基)甲基]苯并[H]喹唑啉-4(3H)-酮,M1 receptor modulator
A positive allosteric modulator of M₁ mAChRs
GC30835 Rislenemdaz (MK-0657)
MK-0657; CERC-301

Rislenemdaz (MK-0657) (CERC-301) 是一种口服生物可利用的选择性 N-甲基-D-天冬氨酸 (NMDA) 受体亚基 2B (GluN2B) 拮抗剂，其 Ki 和 IC 50 分别为 8.1 nM 和 3.6 nM。
GC30827 Pipequaline (PK-8165)
哌夸林,PK-8165
A partial agonist of central benzodiazepine receptors
GC30826 Temanogrel (APD791)
APD791
Temanogrel (APD791) 是一种高度选择性的 5-HT2A 受体拮抗剂，Ki 为 4.9 nM。
GC30824 Veralipride ((±)-Veralipride)
维拉必利,(±)-Veralipride; LIR166

Veralipride ((±)-Veralipride) 是一种 D2 受体拮抗剂。
GC30823 Edonerpic maleate (T-817 maleate)
1-(3-(2-(苯并[B]噻吩-5-基)乙氧基)丙基)氮杂环丁烷-3-醇马来酸,T-817 maleate; T-817MA
T-817MA propyl}-3-azetidinol maleate] 是一种新合成的阿尔茨海默病 (AD) 治疗剂，具有神经保护作用β-淀粉样肽 (Aβ) 的毒性和促进神经突生长的作用.T-817MA 预处理 24 小时后，T-817MA 在 0.1 和 1 uM 时显着防止 H2O2 处理引起的神经元损伤。
GC30822 Solifenacin (YM905)
索利那新; YM905 free base

Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
GC30821 JNJ-39758979 JNJ-39758979是一个有选择性且具有高亲和性的组胺H4受体拮抗剂,其Ki值为12.5nM。
GC30818 ZL006 An nNOS/PSD-95 interaction inhibitor
GC30812 Imidafenacin (KRP-197)
咪达那新; KRP-197; ONO-8025
Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
GC30810 Donepezil (E2020)
多奈哌齐; E2020 free base
Donepezil (E2020)是一种乙酰胆碱酯酶（AChE）抑制剂，IC50为6.7nM。
GC30809 VU0467154
5-氨基-3,4-二甲基-噻吩并[2,3-C]哒嗪-6-羧酸4-三氟甲磺酰基-苄基酰胺
A positive allosteric modulator of the M₄ muscarinic acetylcholine receptor
GC30807 ZSET1446 (ST-101)
ST-101
ZSET1446 (ST-101) 是一种新型认知增强剂，可显着改善各种类型的阿尔茨海默病 (AD) 模型中的学习缺陷。
GC30797 lumateperone Tosylate (ITI-007)
1-(4-氟苯基)-4-[(6BR,10AS)-2,3,6B,9,10,10A-六氢-3-甲基-1H-吡啶并[3',4':4,5]吡咯并[1,2,3-DE]喹喔啉-8(7H)-基]-1-丁酮对甲苯磺酸盐,ITI-007 tosylate

An atypical antipsychotic
GC30796 Nelotanserin (APD125)
1-[3-(4-溴-1-甲基-1H-吡唑-5-基)-4-甲氧基苯基]-3-(2,4-二氟苯基)脲,APD125
Nelotanserin (APD125) 是一种有效的 5-HT2A 反向激动剂、中度有效的 5-HT2C 部分反向激动剂和弱 5-HT2B 反向激动剂，在 IP 积累试验中 IC50 分别为 1.7、79、791 nM。
GC30790 Triflupromazine hydrochloride
盐酸三氟丙嗪
A phenothiazine with diverse biological activities
GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate)
谷氨酸单钠盐
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
GC30787 Sertindole (Lu 23-174)
舍吲哚; Lu 23-174
An atypical antipsychotic
GC30780 Fipexide
非哌西特
Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
GC30775 Histamine (Ergamine)
组胺; Ergamine

A biogenic amine
GC30774 Tat-NR2B9c
Tat-NR2Bct; NA-1
Tat-NR2B9c 旨在通过阻止突触后密度蛋白 95 (PSD-95) 与 N-甲基-D-天冬氨酸 (NMDA) 受体和神经元一氧化氮结合来阻止一氧化氮 (NO) 的产生氧化物合成酶。
GC30773 Phenelzine sulfate
硫酸苯乙肼
Phenelzine sulfate是一种单胺氧化酶（MAO）抑制剂。
GC30772 Dopamine serotonin antagonist-1
氯氮平杂质,Deschloroclozapine
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
GC30766 Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate)
反苯环丙胺半硫酸盐; SKF 385 hemisulfate
Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.
GC30762 Harmine (Telepathine)
去氢骆驼蓬碱; Telepathine
A unique regulator of PPARγ expression
GC30759 H3 receptor-MO-1 H3receptor-MO-1是一种组胺H3受体(histamineH3receptor)调节剂。
GC30752 CCK-B Receptor Antagonist 1
(Rac)-Netazepide; (Rac)-YF 476; (Rac)-YM-220
CCK-B Receptor Antagonist 1 是胆囊收缩素 B (CCK-B) 受体的拮抗剂，具有减少胃酸分泌的潜力。
GC30681 Revexepride Revexepride是一种高度选择性的5-HT4receptor激动剂，也是潜在的CYP3A4enzyme诱导剂，可用于治疗胃食管返流疾病。
GC30680 Gastrin/CCK antagonist 1
Gastrin/CCKantagonist1是gastrin/CCK的拮抗剂，可用于肠胃失调疾病的研究。
GC30674 CHEMBL333994 (FK-480)
FK-480
CHEMBL333994 (FK-480) 是一种有效的口服有效的胆囊收缩素 A (CCK-A) 拮抗剂，IC50 为 0.67 nM。
GC30610 LY 178002
LY178002是一种有效的5-lipoxygenase，phospholipaseA2抑制剂，对5-lipoxygenase的IC50值为0.6μM，能够抑制人多形核白细胞产生LTB4，同时可相对较弱地抑制cyclooxygenase的活性。
GC30544 (2-Chloropyridin-4-yl)methanamine hydrochloride
2-氯-4-氨甲基吡啶; LOXL2-IN-1 hydrochloride
(2-Chloropyridin-4-yl)methanamine hydrochloride是一种高选择性的赖氨酰氧化酶样蛋白-2（LOXL2）抑制剂，其IC₅₀为126nM。
GC30521 Broflanilide
氟苯双酰胺
Broflanilide是一种杀虫剂，可以分解成desmethyl-broflanilide，为特异性的昆虫耐狄氏剂的GABAreceptor拮抗剂，抑制斜纹夜蛾RDLGABAR，IC50值为1.3nM。
GC30496 Doxylamine D5 succinate
琥珀酸多西拉敏 D5
DoxylamineD5琥珀酸盐是Doxylamine氘代化合物标准品。
GC30457 Zonampanel (YM 872)
唑南帕奈; YM 872
Zonampanel (YM 872) (YM 872) 是谷氨酸受体亚型 α；-氨基-3-羟基-5-甲基异恶唑-4-丙酸 (AMPA) 受体的选择性拮抗剂。
GC30455 Rocastine (AHR-11325)
罗卡斯汀,AHR-11325
Rocastine (AHR-11325) 是一种选择性、非镇静 H1 拮抗剂，用作抗组胺药。
GC30446 MHP 133 MHP133是一种多靶点抑制剂，可以抑制AChE的活性，KKi值为69μM;同时抑制毒蕈碱M1和M2受体，5HT4受体和咪唑I2受体。
GC30433 Ru-32514 Ru-32514是一种苯二氮受体(benzodiazepinereceptor)激动剂。
GC30426 YM-58790 YM-58790是一种有效的M3muscarinic受体拮抗剂，Ki值为15nM。
GC30423 CP-66948 CP-66948是histamineH2受体拮抗剂，能够抑制胃酸分泌，保护粘膜的作用。
GC30413 Dolasetron Mesylate (MDL-73147EF)
甲磺酸多拉司琼,MDL-73147EF
A 5-HT₃ receptor antagonist
GC30412 Dolasetron (MDL-73147)
多拉司琼,MDL-73147
A 5-HT₃ receptor antagonist
GC30409 Elucaine
普罗卡因
Elucaine是蕈毒碱型乙酰胆碱受体(mAChR)拮抗剂，具有抗溃疡功效。
GC30396 Piribedil D8 (ET-495 D8)
吡贝地尔D8,ET-495 D8
Piribedil D8 (ET-495 D8) (ET-495 D8) 是氘标记的 Piribedil，它是一种抗帕金森病药物。
GC30392 Desmethoxyyangonin (Demethoxyyangonin)
去甲氧基醉椒素,Demethoxyyangonin; 5,6-Dehydrokavain
An Analytical Reference Standard
GC30375 Clomipramine D3
Chlorimipramine-d3; G-34586-d3; NSC-169865-d3
An Analytical Reference Standard