Neuroscience
Neuroscience(神经科学)
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more
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Neuroscience 相关产品(3932)
- GC31046Scopolamine (Hyoscine)CAS: 51-34-3纯度: >98.00%
Scopolamine (Hyoscine)是一种天然托烷类生物碱，是一种高亲和力的竞争性毒蕈碱型乙酰胆碱受体（mAChRs）拮抗剂。Scopolamine以可逆方式抑制5-HT 3 受体反应，其IC 50 值为2.09μM。
- GC31054Alniditan (Alnitidan)CAS: 152317-89-0
Alniditan (Alnitidan) (Alnitidan) 是一种有效的 5-HT1B 和 5-HT1D 受体激动剂，在 HEK293 细胞中对 h5-HT1B 和 h5-HT1D 受体的 IC50 分别为 1.7 nM 和 1.3 nM。
- GC31057Naluzotan (PRX 00023)CAS: 740873-06-7
Naluzotan (PRX 00023) 是一种新型的、有效的、选择性的氨基磺酰胺 5-HT1A 激动剂，IC50 和 Ki 分别为 20 nM 和 5.1 nM，用于治疗焦虑和抑郁。也是一种弱 hERG K+ 通道阻断剂，IC50 为 3800 nM。
- GC31064Duloxetine ((S)-Duloxetine)CAS: 116539-59-4纯度: >98.00% / >99.50%
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
- GC31069Pardoprunox (SLV-308)CAS: 269718-84-5
Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC31039 | RPR104632 | 154106-92-0 | - | |
RPR104632是一种特异性的NMDAreceptor拮抗剂，具有神经保护的作用。 | ||||
| GC31041 | Wf-516 | 310392-94-0 | - | |
Wf-516是一种5-HTreuptake的抑制剂，同时为5-HT1A和5-HT2A受体拮抗剂，对人体5-HT1A和5-HT2A受体的Ki值分别为5nM和40nM，具有抗抑郁作用。 | ||||
| GC31042 | Propantheline bromide | 50-34-0 | - | |
An anticholinergic agent | ||||
| GC31044 | T 82 | 252264-92-9 | - | |
T82是一种有效的5-HT3拮抗剂和乙酰胆碱酯酶(AChE)的抑制剂，用于阿尔茨海默症的研究。 | ||||
| GC31046 | Scopolamine (Hyoscine) | 51-34-3 | >98.00% | |
Scopolamine (Hyoscine)是一种天然托烷类生物碱，是一种高亲和力的竞争性毒蕈碱型乙酰胆碱受体（mAChRs）拮抗剂。Scopolamine以可逆方式抑制5-HT 3 受体反应，其IC 50 值为2.09μM。 | ||||
| GC31047 | Bromopride | 4093-35-0 | - | |
A dopamine D 2 receptor antagonist | ||||
| GC31048 | Clidinium bromide (Ro 2-3773) | 3485-62-9 | >98.00% | |
A muscarinic receptor antagonist | ||||
| GC31049 | RWJ-51204 | 205701-85-5 | - | |
RWJ-51204是GABA(A)receptor的部分激动剂，Ki值为0.2-2nM。 | ||||
| GC31052 | CP-409092 | 194098-25-4 | - | |
CP-409092是GABA(A)的部分激动剂，主要用于抗焦虑研究。 | ||||
| GC31054 | Alniditan (Alnitidan) | 152317-89-0 | - | |
Alniditan (Alnitidan) (Alnitidan) 是一种有效的 5-HT1B 和 5-HT1D 受体激动剂，在 HEK293 细胞中对 h5-HT1B 和 h5-HT1D 受体的 IC50 分别为 1.7 nM 和 1.3 nM。 | ||||
| GC31055 | Abaperidone | 183849-43-6 | - | |
Abaperidone是一种有效的5-HT2A受体和多巴胺D2受体拮抗剂，IC50分别为6.2和17nM。 | ||||
| GC31056 | Piperidolate | 82-98-4 | >99.00% | |
Piperidolate是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。 | ||||
| GC31057 | Naluzotan (PRX 00023) | 740873-06-7 | - | |
Naluzotan (PRX 00023) 是一种新型的、有效的、选择性的氨基磺酰胺 5-HT1A 激动剂，IC50 和 Ki 分别为 20 nM 和 5.1 nM，用于治疗焦虑和抑郁。也是一种弱 hERG K+ 通道阻断剂，IC50 为 3800 nM。 | ||||
| GC31064 | Duloxetine ((S)-Duloxetine) | 116539-59-4 | >98.00% / >99.50% | |
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. | ||||
| GC31069 | Pardoprunox (SLV-308) | 269718-84-5 | - | |
Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively. | ||||
| GC31072 | Camylofine | 54-30-8 | - | |
Camylofin是一种抗胆碱剂,是一种平滑肌松弛剂。 | ||||
| GC31076 | GNE 5729 | 2026635-66-3 | >98.50% | |
GNE5729是一种可透过血脑屏障的NMDAR的正向调节剂，对GluN2A的EC50值为37nM，对GluN2C和GluN2D的EC50值分别为4.7和9.5μM。 | ||||
| GC31083 | DWK-1339 (MDR-1339) | 1018946-38-7 | >98.00% | |
An inhibitor of amyloid-β aggregation | ||||
| GC31084 | (-)-(S)-B-973B | 2244989-34-0 | >99.50% | |
(-)-(S)-B-973B为一种有效的α7nAChR别构激动剂和正别构调节剂，具有镇痛作用。 | ||||
| GC31086 | TAK-071 | 1820812-16-5 | >98.50% | |
TAK-071是一种新型,高效，选择性的毒蕈碱乙酰胆碱受体1(M1R)正变构调节剂。TAK-071激活M1R的EC50为520nM。 | ||||
| GC31094 | CR4056 | 1004997-71-0 | - | |
CR4056是一个选择性的人重组MAO-A抑制剂，其IC50值为202.7nM。CR4056也是咪唑啉-2受体(I2R)的配体，其IC50值为596nM。 | ||||
| GC31104 | Isocarboxazid | 59-63-2 | >98.50% | |
An inhibitor of MAO | ||||
| GC31105 | S 38093 | 862896-30-8 | >99.50% | |
S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors. | ||||
| GC31107 | CGRP antagonist 1 | 1123757-49-2 | - | |
CGRPantagonist1是高效的CGRP受体拮抗剂，Ki和IC50值分别为35和57nM。 | ||||