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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC30973 Mephenesin

    甲酚甘油醚

     Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.
  3. GC30972 Lidanserin (ZK-33839)

    利丹色林,ZK-33839

     Lidanserin (ZK-33839) (ZK-33839) 作为 5-HT2A 和 α1-肾上腺素能受体拮抗剂起作用。
  4. GC30971 Rapacuronium bromide (Org 9487)

    Org 9487

     雷帕库溴铵 (Org 9487) (Org 9487) 是一种非去极化神经肌肉阻滞剂，是毒蕈碱乙酰胆碱受体 (mAChR) 的变构调节剂。
  5. GC30968 Metixene hydrochloride hydrate

    美噻吨盐酸盐水合物；甲哌噻吨盐酸盐水合物

     Metixenehydrochloridehydrate是一种抗胆碱能、抗帕金森剂，能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体(muscarinicreceptor)结合，IC50和Kd值分别为55nM和15nM。
  6. GC30964 Vabicaserin hydrochloride (SCA 136)

    SCA 136

     Vabicaserin hydrochloride (SCA 136) 是一种 5-羟色胺 2C (5-HT2C) 受体选择性激动剂，EC50 为 8 nM。
  7. GC30963 Eprobemide (LIS 630)

    依普贝胺,LIS 630

     Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.
  8. GC30955 Cimetropium Bromide (DA-3177)

    西托溴铵; DA-3177

     Cimetropium Bromide (DA-3177) (DA-3177) 是一种 mAChR 拮抗剂，用于长期治疗肠易激综合征。
  9. GC30953 Phenylbiguanide (N-Phenylbiguanide)

    1-苯基双胍,N-Phenylbiguanide; PBG; 1-Phenylbiguanide

     1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.
  10. GC30952 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine是一种有效的淀粉样蛋白显像剂，其与淀粉样蛋白Amyloid-β(1-40)结合的KD值为1.7nM。
  11. GC30951 MDL 105519

    3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸

     MDL105519是有效和选择性的甘氨酸与NMDA受体结合的拮抗剂。
  12. GC30949 Minaprine dihydrochloride

    米那卜林二盐酸盐

     Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂，还对乙酰胆碱酯酶有微弱抑制，抗抑郁类化合物。
  13. GC30948 Chlorphenoxamine

    氯苯沙明；氯苯氧胺

     Chlorphenoxamine是一种抗组胺剂和抗胆碱能药,用作抗帕金森氏病。
  14. GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)

    丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride

     A muscarinic acetylcholine receptor antagonist
  15. GC30945 Y1 receptor antagonist 1

    H 409-22 isomer

    Y1receptorantagonist1是H-409/22的一个异构体，是神经肽(neuropeptideY1)受体拮抗剂。
  16. GC30944 Sultopride hydrochloride (LIN-1418 hydrochloride)

    盐酸舒必利; LIN-1418 hydrochloride

     Sultopride hydrochloride (LIN-1418 hydrochloride) (LIN-1418 hydrochloride) 是多巴胺 D2 受体的选择性拮抗剂。
  17. GC30943 6,2'-Dihydroxyflavone

    6,2-二羟基黄酮

     6,2'-Dihydroxyflavone是一个新型的GABAA受体拮抗剂。
  18. GC30939 Eptapirone (F 11440)

    F 11440

     A potent and selective 5-HT1A receptor agonist
  19. GC30933 (+)-Kavain

    醉椒素

     A kavalactone with diverse biological activities
  20. GC30930 DAA-1106

    N-(2,5-二甲氧基苄基)-N-(5-氟-2-苯氧基苯基)乙酰胺

     A TSPO agonist
  21. GC30926 Lurasidone (SM-13496)

    鲁拉西酮; SM-13496

     An atypical antipsychotic
  22. GC30925 Benzetimide hydrochloride (R4929)

    盐酸苄替米特,R4929

    A muscarinic acetylcholine receptor antagonist
  23. GC30920 K 01-162 (K162)

    K162

     K 01-162 (K162) (K162) 抑制 Aβ 的原纤维形成；肽并消除其神经毒性。
  24. GC30912 Piperidolate hydrochloride

    盐酸哌立度酯

     Piperidolate盐酸盐是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。
  25. GC30911 Apimostinel (NRX-1074)

    NRX-1074; AGN-241660

    Apimostinel (NRX-1074) (NRX-1074; AGN-241660) 是一种具有口服活性的 NMDA 受体部分激动剂。
  26. GC30910 Eucalyptol (1,8-Cineole)

    NSC 6171

     Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。
  27. GC30908 Drofenine hydrochloride (Hexahydroadiphenine hydrochloride)

    盐酸六氢芬宁,Hexahydroadiphenine hydrochloride

     Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers.
  28. GC30907 AVN-492 A 5-HT6 receptor antagonist
  29. GC30904 Molindone hydrochloride (EN-1733A)

    EN-1733A

     A dopamine receptor antagonist
  30. GC30902 Dimenhydrinate

    乘晕宁

     Dimenhydrinate is an over-the-counter drug used to prevent nausea, vomiting, and dizziness caused by motion sickness.
  31. GC30901 Scopolamine N-oxide hydrobromide (Hyoscine N-oxide hydrobromide)

    东莨菪碱N-氧化物氢溴酸盐一水合物

    Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
  32. GC30898 6-Methylflavone

    6-甲基黄酮

     6-methylflavone是α1β2γ2L和α1β2GABAA受体的激活剂。
  33. GC30892 Glutaminyl Cyclase Inhibitor 1 GlutaminylCyclaseInhibitor1是谷氨酰胺酰基环化酶(glutaminylcyclase)抑制剂，IC50值为0.5μM。
  34. GC30889 (-)-Securinine

    一叶秋碱

     An alkaloid
  35. GC30888 8-OH-DPAT (8-Hydroxy-DPAT)

    8-Hydroxy-DPAT

    8-OH-DPAT 是5-HT1A 激动剂， pIC50 值为 8.19 ，此外8-OH-DPAT对5-HT1B(pIC50 , 5.42)和5-HT (pIC50 <5)受体亲和力都很弱 。
  36. GC30884 LX2343 An inhibitor of BACE1 and PI3K
  37. GC30880 LP-211 LP-211是一种选择性的、可透过血脑屏障的5-HT7受体（Ki=0.58nM）激动剂，选择性高于5-HT1A受体（Ki=188nM）和D2受体（Ki=142nM）。
  38. GC30876 PF-06751979 PF-06751979是一种有效的，脑渗透性的β-淀粉样前体蛋白裂解酶1(BACE1)抑制剂，IC50为7.3nM。
  39. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)

    6-羟基多巴胺盐酸盐; 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride

     Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)（6-OHDA）是神经递质多巴胺的拮抗剂。
  40. GC30870 Nialamide

    烟肼酰胺

    Nialamide是一种非选择性的,不可逆的单胺氧化酶抑制剂(MAOI),用作抗抑郁药。
  41. GC30866 Anabasine ((S)-Anabasine)

    (+)-假木贼碱; (S)-Anabasine; (+)-Anabasine

     Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) 是一种生物碱，在烟草 (Nicotiana) 中是一种微量成分。
  42. GC30865 TPA 023 TPA023是GABAAα2/α3的选择性的激动剂，Ki值为0.19-0.41nM。
  43. GC30862 L-Cycloserine ((S)-4-Amino-3-isoxazolidone)

    环丝氨酸,(S)-Cycloserine; (S)-4-Amino-3-isoxazolidone

     An inhibitor of sphingolipid synthesis and aminotransferases
  44. GC30861 Pavinetant (MLE-4901)

    MLE-4901; AZD2624; AZD4901

     An NK3 receptor antagonist
  45. GC30860 Neu2000

    Salfaprodil free base; Neu2000

     Neu2000 (Salfaprodil free base) 是 N-甲基-D-天冬氨酸 (NMDA) 的 NR2B 选择性和非竞争性拮抗剂。
  46. GC30859 AC260584 AC260584是M1毒蕈碱受体变构激动剂，pEC50值为7.6。
  47. GC30856 Protriptyline hydrochloride

    盐酸普罗替林

    A tricyclic antidepressant
  48. GC30854 Pridopidine (ACR16)

    4-[3-(甲磺酰基)苯基]-1-丙基哌啶,ACR16; ASP2314; FR310826

     Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).
  49. GC30852 Org-26576 Org26576是AMPA受体的正变构调节剂。
  50. GC30849 DREADD agonist 21 A muscarinic hM3Dq DREADD agonist
  51. GC30848 (+)-PD 128907 hydrochloride

    (+)-PD128907,盐酸盐

    A potent D3 receptor agonist

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