MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.
MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1].
MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1].
[1]. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275