Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC40286 (E,Z)-2-propyl-2-Pentenoic Acid
2-丙基-2-戊烯酸
A valproic acid metabolite
GC40262 α-Humulene
ALPHA-律草烯,Humulene; α-Caryophyllene
A sesquiterpene with diverse biological activities
GC34944 β-CGRP, human TFA
Human β-CGRP TFA; CGRP-II (Human) (TFA)
β-CGRP, human TFA是一种神经肽激素，由降钙素基因相关肽家族产生，可与降钙素受体样受体CRLR和RAMP形成复合物（CRLR/RAMP1：IC₅₀ = 1nM；CRLR/RAMP2：IC₅₀ = 300nM）。
GC34842 Toloxatone
托洛沙酮; MD 69276

An inhibitor of MAO-A
GC34828 Tat-NR2B9c TFA
Tat-NR2Bct TFA; NA-1 TFA
Tat-NR2B9c(TFA)是由20个氨基酸组成的多肽，为PSD-95的抑制剂，对PSD-95d2和PSD-95d1的EC50值分别为6.7nM和670nM。Tat-NR2B9c同时可降低NMDA诱导的p38的活化，具有神经保护作用。
GC34753 Radiprodil
RGH-896

An NMDA receptor antagonist
GC34684 Neurokinin B TFA
神经激肽 B 三氟乙酸盐
NeurokininBTFA属于速激肽家族。Neurokinin结合到一系列G蛋白偶联受体(GPCR)-包括神经激肽受体1(NK1R)，NK2R和NK3R，且介导其生物学作用。
GC34683 Neurokinin A(4-10) TFA NeurokininA(4-10)TFA是速激肽NK2受体激动剂。
GC34638 JNJ-61432059 JNJ-61432059是具有口服活性的、选择性的AMPAR的负向调节剂，其对GluA1/γ-8的pIC50值为9.7。在老鼠的海马体中显示出具有时间和剂量依赖性的AMPA受体占用情况，在角膜点燃癫痫动物模型中显示出较强的保护作用。
GC34575 Eplivanserin mixture
SR-46349 (mixture)
Eplivanserinmixture是一种选择性的血清素再摄取抑制剂，是5-HT2A受体的拮抗剂。化合物信息来自专利WO2005/002578A1。
GC34559 DOV-216,303 Free Base
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷
DOV-216,303(FreeBase)是有效的5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对hSERT、hNET和hDAT的IC50值分别为14nM，20nM和78nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。
GC34494 Bifenazate
联苯肼酯
An acaricide
GC34477 AT-1002 TFA AT-1002 TFA 是一种六聚体合成肽，可降低跨上皮细胞电阻（TEER）。
GC19514 1-Methyl-L-tryptophan
相思子碱
An IDO inhibitor
GC19499 A-381393 A-381393 是一种有效的、选择性的脑穿透多巴胺 D4 受体拮抗剂，对人多巴胺 D4.4、D4.2 和 D4.7 受体的 Kis 分别为 1.5、1.9 和 1.6 nM，比选择性高 2700 倍以上D1、D2、D3 和 D5 多巴胺受体。
GC40237 Ramelteon-d5
TAK-375-d5
An internal standard for the quantification of ramelteon
GC40227 Indomethacin-d4
吲哚美辛-D4; Indometacin-d4
An internal standard for the quantification of indomethacin
GC40225 Olanzapine-d8
奥氮平-d8
An internal standard for the quantification of olanzapine
GC40196 Levetiracetam-d6
左乙拉西坦杂质-d6,UCB L059-d6
Levetiracetam-d6是Levetiracetam的氘代衍生物，是一种含有6个氘原子的稳定同位素标记化合物。
GC40191 Ibuprofen Carboxylic Acid
羧基布洛芬
A major metabolite of ibuprofen
GC40190 Febuxostat Acyl Glucuronide
非布司他杂质
A metabolite of febuxostat
GC40184 Probenecid-d14
丙磺舒 d14
An internal standard for the quantification of probenecid
GC40176 1-Stearoyl-rac-glycerol
单硬脂酸甘油酯
A monoacylglycerol
GC40161 ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
Adrenocorticotropic Hormone (4-10), Corticotropin (4-10)
An endogenous peptide fragment of ACTH
GC40159 PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)
H-Ser-Phe-Phe-Leu-Arg-Asn, PAR1-AP, Proteinase-Activated Receptor 1, SFFLRN, TRAP, Thrombin Receptor Activating Peptide
A peptide agonist of PAR1
GC40145 (S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
The (S) enantiomer of laudanosine
GC40143 Dihydrotetrabenazine
反式(2,3)-二氢丁苯那嗪
An active metabolite of tetrabenazine
GC40142 Lactosylceramides (bovine buttermilk)
乳糖苷
A sphingolipid
GC40132 ACTH (6-24) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
HFRWGKPVGKKRRPVKVYP
A peptide fragment of ACTH
GC40125 Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)
Caspase-1 Inhibitor V, Z-VAD-FMK, Z-VAD(OMe)-FMK, Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone
A pan-caspase inhibitor
GC40114 Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
GC40105 βARK1 Inhibitor
呋喃妥因-13C3
An inhibitor of GRK2/βARK1
GC40078 Memantine-d6 (hydrochloride)
盐酸美金刚 d6 (盐酸盐)
An internal standard for the quantification of memantine
GC40077 Brimonidine-d4
溴莫尼定 d4
An internal standard for the quantification of brimonidine
GC40068 Setosusin
(+)-Setosusin
A fungal metabolite
GC40065 Meloxicam-d3
美洛昔康 d3
An internal standard for the quantification of meloxicam
GC40053 5α,6α-epoxy Cholestanol
胆固醇-5Α,6Α-环氧化物,NSC 18176
5α,6α-epoxy Cholestanol 是一种胆固醇衍生物，可以通过线粒体中的细胞色素P450酶系催化生成或是在脂质过氧化过程中诱导生成，可调节胆汁酸的生物合成、诱导肿瘤细胞的分化和死亡。
GC40045 4-(Dimethylamino)-1-methylpyridinium (iodide) A pyridinium salt
GC40044 Zymostenol
Δ8-Cholesterol
A precursor of cholesterol
GC40043 Totarol
桃柁酚,NSC 299936, (+)-Totarol, trans-Totarol
Totarol是一种非特异性细菌细胞分裂蛋白FtsZ的抑制剂。
GC40042 Cholesteryl Erucate
胆固醇芥酸甲酯
A cholesterol ester
GC40041 Cholesteryl Lignocerate
24:0 CE, 24:0 Cholesterol ester
A cholesterol ester
GC40027 True Blue
NCI 240899
A fluorescent neuronal retrograde tracer
GC40024 Altenusin
细格菌素,Alutenusin
A fungal metabolite with diverse biological activities
GC40018 Donepezil N-oxide
多奈哌齐N氧化物
An active metabolite of donepezil
GC40016 Ganglioside GM2 Mixture (sodium salt)
单唾液酸神经节苷脂GM2; GM2; Monosialoganglioside GM2
A mixture of ganglioside G_M2
GC34418 Netupitant D6 (CID-6451149 D6) An internal standard for the quantification of netupitant
GC34408 Monohydroxy Netupitant D6 MonohydroxyNetupitantD6是MonohydroxyNetupitant的氘代化合物标准品。
GC34396 Calcitonin Gene Related Peptide (CGRP) (83-119), rat CalcitoninGeneRelatedPeptide(CGRP)(83-119),rat是一种由37个氨基酸组成的降钙素家族神经肽，通过(CRLR)起作用。
GC34395 Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA CalcitoninGeneRelatedPeptide(CGRP)(83-119),rat(TFA)是一种由37个氨基酸组成的降钙素家族神经肽，通过(CRLR)起作用。