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Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

研究方向

Neuroscience 相关产品(3932)

  • GC60592 structure
    GC60592APS6-45
    CAS: 2188236-41-9
    纯度: >99.50%

    APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.

  • GC60596 structure
    GC60596Arecaidine
    CAS: 499-04-7
    纯度: >98.00%

    Arecaidine，一种吡啶生物碱，是一种有效的GABA吸收抑制剂。Arecaidine是H+偶联的氨基酸转运蛋白1(PAT1，SLC36A1)的底物，竞争性抑制L-脯氨酸的摄取。

  • GC60630 structure
    GC60630Befiradol hydrochloride
    CAS: 2436760-81-3
    纯度: >99.50%

    Befiradolhydrochloride(NLX-112hydrochloride)是选择性的5-羟色胺1A(5-HT)1A受体激动剂。

  • GC60641 structure
    GC60641Betahistine mesylate
    CAS: 54856-23-4
    纯度: >98.00%

    Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.

  • GC60662 structure
    GC60662Brexpiprazole S-oxide
    CAS: 1191900-51-2

    BrexpiprazoleS-oxide(DM-3411)是Brexpiprazole的主要代谢产物，并通过细胞色素P4503A4(CYP3A4)代谢。Brexpiprazole是一种非典型抗精神病药，是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12nM和0.3nM。Brexpiprazole也是5-HT2A受体的拮抗剂，Ki为0.47nM。

  • GC60691 structure
    GC60691Cetirizine Impurity C
    CAS: 83881-59-8

    CetirizineImpurityC是Cetirizine的一种杂质。Cetirizine是羟嗪的羧化代谢物，是第二代抗组胺剂。Cetirizine是一种特异的、具有口服活性的H1受体(histamineH1-receptor)的长效拮抗剂。

  • GC60709 structure
    GC60709Cinnarizine D8
    CAS: 1185242-27-6

    An internal standard for the quantification of cinnarizine

  • GC60723 structure
    GC60723COR659
    CAS: 544450-68-2
    纯度: >99.50%

    COR659是GABAB的阳性变构调节剂(PAM)。COR659可缓解大鼠对酒精和巧克力的药物成瘾。

  • GC60740 structure
    GC60740Dapoxetine-D7 hydrochloride
    CAS: 129938-20-1
    纯度: >99.50%

    Dapoxetine-D7(LY-210448-D7)hydrochloride是Dapoxetinehydrochloride的氘代物。Dapoxetinehydrochloride是一种短效的选择性5-羟色胺再摄取抑制剂(SSRI)。

  • GC60758 structure
    GC60758Deschloroclozapine
    CAS: 1977-07-7
    纯度: >98.00%

    Deschloroclozapine是一种高亲和力、选择性且代谢稳定的毒蕈碱DREADD激动剂，Deschloroclozapine能快速穿透血脑屏障，有效激活兴奋性hM3Dq和抑制性hM4Di DREADD受体。

  • GC60774 structure
    GC60774Dihydro Donepezil
    CAS: 120012-04-6

    DihydroDonepezil(DihydroE2020)是Donepezil的代谢产物。Donepezil是一种有效的特异性AChE抑制剂，对bAChE和hAChE的IC50分别为8.12nM和11.6nM。

  • GC60791 structure
    GC60791Doxepin D3 Hydrochloride
    CAS: 347840-07-7

    DoxepinD3Hydrochloride是DoxepinHydrochloride的氘代物。Doxepinhydrochloride是一种口服活性的三环抗抑郁药。Doxepinhydrochloride是一种有效的选择性组胺受体H1拮抗剂。Doxepinhydrochloride也是一种有效的CYP450抑制剂，并显着抑制CYP4502C19和CYP4501A2。

  • GC60846 structure
    GC60846Flesinoxan
    CAS: 98206-10-1
    纯度: >99.00%

    Flesinoxan是一种降压剂，是一种有效的，高亲和力的选择性的5-羟色胺1A(5-HT1A)受体激动剂，EC50值为24nM。Flesinoxan还具有有效的抗焦虑/抗抑郁作用。

  • GC60862 structure
    GC60862GABAA receptor agent 1
    CAS: 1571-87-5
    纯度: >98.50%

    GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.

  • GC60866 structure
    GC60866Gap 26 TFA
    纯度: >98.00%

    Gap 26, a connexin mimetic peptide that composeds of residue no. 63-75 of the extracellular loop 1 of connexin 43 (Cx43), is a gap junction inhibitor. Gap 26 blocks photoliberating inositol-1,4,5-trisphosphate triggers ATP release.

  • GC60875 structure
    GC60875GKT136901
    CAS: 955272-06-7
    纯度: >99.00%

    A dual inhibitor of NOX1 and NOX4

  • GC60886 structure
    GC60886GSK356278
    CAS: 720704-34-7
    纯度: >99.50%

    A selective PDE4 inhbitor

  • GC60890 structure
    GC60890Guvacine
    CAS: 498-96-4

    An inhibitor of GABA uptake

  • GC60913 structure
    GC60913Huperzine C
    CAS: 163089-71-2

    HuperzineC是从Huperziaserrate中分离的一种生物碱。HuperzineC是一种乙酰胆碱酯酶(AChE)抑制剂，其IC50值为0.6μM。HuperzineC可用于阿尔茨海默症的研究。

  • GC60915 structure
    GC60915Hydroxy ziprasidone
    CAS: 884305-08-2

    Hydroxyziprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。

  • GC60917 structure
    GC60917Hydroxyamine hydrochloride
    CAS: 5470-11-1
    纯度: >99.00%

    Hydroxylammonium chloride (Hydroxylamine hydrochloride) is the hydrochloric acid salt of hydroxylamine, which is a biological intermediate in the nitrification and in the anammox.

  • GC60924 structure
    GC60924Hydroxyzine D8
    CAS: 1189480-47-4

    An internal standard for the quantification of hydroxyzine

  • GC60926 structure
    GC60926Ibuprofen impurity 1
    CAS: 3585-47-5

    Ibuprofenimpurity1是Ibuprofen的杂质。Ibuprofen是COX-1和COX-2的抑制剂，IC50值分别为13μM和370μM，具有抗炎的活性。

  • GC60935 structure
    GC60935Indomethacin sodium hydrate
    CAS: 74252-25-8
    纯度: >98.00%

    A non-selective COX inhibitor