Signaling Pathways(信号通路)

Cat.No. 产品名称 Information

GC52100 (Arg)9 (trifluoroacetate salt)

Nona-Arginine, Poly-Arginine-9, RRRRRRRRR

A cationic cell-penetrating peptide

GC12395 (D)-(+)-Neopterin

新蝶呤,D-(+)-Neopterin; D-erythro-Neopterin

A biochemical tool to screen for immune disorders

GC50482 (D)-PPA 1 An inhibitor of the PD-1-PD-L1 protein-protein interaction

GC52442 (D)-PPA 1 (trifluoroacetate salt)

DPPA-1, NYSKPTDRQYHF

An inhibitor of the PD-1-PD-L1 protein-protein interaction

GC69009 (D)-PPA 1 TFA (D)-PPA 1 TFA 是一种抗水解 D 肽拮抗剂。(D)-PPA 1 TFA 是一种有效的 PD-1/PD-L1 抑制剂。(D)-PPA 1 TFA 与 PD-1 结合的亲和力为 0.51 μM，体内外均有效。

GC41698 (D)2-Rh 110 (trifluoroacetate salt)

D2R, (Asp)2-Rhodamine 110, Rhodamine 110 bis-(L-aspartic acid amide)

A fluorogenic caspase substrate

GA20063 (D-Ala²)-Gastric Inhibitory Polypeptide (human)

D-ALA2]-GIP(HUMAN)-胃抑素

GIP receptor agonist.

GA20156 (D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (free base)

戈舍瑞林; ICI 118630

GC41699 (Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt) A peptide hormone

GC60399 (E)-10-Hydroxynortriptyline

E-10-OH-NT

An active metabolite of amitriptyline and nortriptyline

GC41700 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

CSTMP

A stilbene derivative with antioxidant and anticancer activities

GC15373 (E)-2-Decenoic acid

反式-2-癸烯酸,trans-2-Decenoic acid

An unsaturated fatty acid found in royal jelly

GC41268 (E)-2-Hexadecenal

trans-2-Hexadecenal

A long-chain fatty aldehyde

GC41701 (E)-2-Hexadecenal Alkyne A click chemistry probe for a sphingolipid degradation product

GC66255 (E)-3,4,5-Trimethoxycinnamic acid

TMCA

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) 是一种被多甲氧基取代的肉桂酸。(E)-3,4,5-Trimethoxycinnamic acid 是一种口服有效的 GABAA/BZ 受体激动剂。(E)-3,4,5-Trimethoxycinnamic acid 与 5-HT2C 和 5-HT1A 受体具有良好的结合亲和力，其 IC50 值分别为 2.5 和 7.6 μM。(E)-3,4,5-Trimethoxycinnamic acid 具有抗惊厥和镇静活性。(E)-3,4,5-Trimethoxycinnamic acid 可用于失眠、头痛、癫痫的研究。

GC65239 (E)-3,4-(Methylenedioxy)cinnamic acid

(2E)-3-(1,3-苯并二氧杂环戊-5-基)-2-丙烯酸,(E)-Piperonylprop-2-enoic acid

(E)-3,4-(Methylenedioxy)cinnamic acid 是从Brombya platynema的茎皮中获得的肉桂酸衍生物。

GC72618 (E)-3,4-Dimethoxychalcone (E)-3,4-Dimethoxychalcone是3,4-二甲氧基查尔酮的同工型，是一种潜在的抗菌剂和抗氧化剂。

GC61668 (E)-3,4-Dimethoxycinnamic acid

(E)-3,4-二甲氧基肉桂酸; (E)-O-Methylferulic acid

(E)-3,4-Dimethoxycinnamicacid是3,4-Dimethoxycinnamicacid的低活性异构体。3,4-Dimethoxycinnamicacid是从Securidacainappendiculata中提取和纯化的单体。3,4-Dimethoxycinnamicacid通过ROS介导的信号途径对L-02细胞发挥抗凋亡作用。

GC34978 (E)-4-Hydroxytamoxifen

(E)-4-羟基他莫昔芬; (E)-Afimoxifene

(E)-4-Hydroxytamoxifen 是 (Z)-4-hydroxytamoxifen 的低活性异构体，是雌激素受体 (estrogen receptor) 调节剂。

GC41702 (E)-5-(2-Bromovinyl)uracil

(E)-5-(2-溴乙烯基)-2-脱氧尿苷

A pyrimidine base

GC40295 (E)-8-Methyl-6-nonenoic Acid

(E)-8-甲基-6-壬烯酸

A potential thermal degradant of capsaicin

GC34125 (E)-[6]-Dehydroparadol (E)-[6]-Dehydroparadol来自专利US9272994化合物M15,能够抑制人体癌细胞生长并且诱导细胞凋亡。在HCT-116和H-1299细胞中的IC50值分别为43.02和41.59μM。

GC49003 (E)-Ajoene

NSC 614554

A disulfide with diverse biological activities

GC62122 (E)-Akt inhibitor-IV

(E)-AKTIV

(E)-Akt inhibitor-IV is a PI3K-Akt inhibitor, with potent cytotoxic.

GC32522 (E)-Alprenoxime (CDDD-1815)

CDDD-1815

(E)-Alprenoxime (CDDD-1815) 是 Alprenoxime 的异构体。

GC41703 (E)-C-HDMAPP (ammonium salt)

(E)5hydroxy4methylpent3enyl pyrophosphate

Activator of γδ-T-lymphocytes

GC62733 (E)-Coniferin

松柏苷,(E)-Laricin

(E)-Coniferin 是Coniferin 的一种异构体。Coniferin (Laricin) 是松柏醇的一种葡萄糖苷。Coniferin 抑制真菌生长和黑化反应。

GC70220 (E)-Crotylbarbital (E)-Crotylbarbital是巴比妥的异构体。

GC17800 (E)-FeCP-oxindole VEGFR-2 inhibitor

GC46335 (E)-Fenpyroximate

唑螨酯

A phenoxypyrazole acaricide

GC34980 (E)-Ferulic acid

反式阿魏酸,(E)-Coniferic acid

Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.

GC66371 (E)-Ferulic acid-d3

(E)-Coniferic acid-d3

(E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) 是 (E)-Ferulic acid 的氘代物。(E)-Ferulic acid 是阿魏酸 (Ferulic acid) 的异构体，阿魏酸是芳香族化合物，在植物细胞壁中丰富。 (E)-Ferulic acid 引起 β-连环蛋白 (β-catenin) 的磷酸化，导致蛋白酶体降解，增加促凋亡因子 Bax 的表达并降低促存活因子存活蛋白的表达。(E)-Ferulic acid 可以有效去除活性氧 (ROS) 和抑制脂质过氧化。(E)-Ferulic acid 在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。

GC34981 (E)-Flavokawain A

卡瓦胡椒素A

A chalcone with diverse biological activities

GC46336 (E)-Guggulsterone

孕二烯二酮,(E)-Guggulsterone

A farnesoid X receptor antagonist

GC91418 (E)-KPT-330

KTP-330; trans Selinexor

(E)-KPT-330是selinexor的代谢产物，它是exportin 1 (XPO1/CRM1)抑制剂的一种。它由细胞色素P450（CYP）亚型CYP3A4从selinexor中形成。

GC34982 (E)-LHF-535 (E)-LHF-535 是 LHF-535 的异构体. LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50 分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM，详细信息请参考专利文献 WO2012006552A1 中的化合物 1。

GC38684 (E)-m-Coumaric acid

3-羟基肉桂酸

3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar.

GC61437 (E)-Methyl 4-coumarate

4-羟基肉桂酸甲酯; Methyl trans-p-coumarate

A phenol with diverse biological activities

GC62734 (E)-Oct-2-enoic acid

2-辛烯酸

2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.

GC63903 (E)-Osmundacetone

(E)-紫萁酮

(E)-Osmundacetone 是 Osmundacetone 的异构体。Osmundacetone 可以显着抑制 MAPK 磷酸化，包括 JNK，ERK 和 p38 激酶，具有抗氧化应激的神经保护作用。

GC72591 (E,E)-RGFP966 (E,E)-RGFP966是一种选择性、可穿透中枢神经系统的HDAC3抑制剂，可用于亨廷顿病的研究。

GC40286 (E,Z)-2-propyl-2-Pentenoic Acid

2-丙基-2-戊烯酸

A valproic acid metabolite

GC49189 (E/Z)-4-hydroxy Tamoxifen-d5

Afimoxifene-d5, 4-OHT-d5

An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen

GC61807 (E/Z)-AG490

酪氨酸磷酸化抑制剂AG490,(E/Z)-Tyrphostin AG490; (E/Z)-Tyrphostin B42

(E/Z)-AG490((E/Z)-TyrphostinAG490)是(E)-AG490和(Z)-AG490的消旋体。(E)-AG490是一种酪氨酸激酶抑制剂，可抑制EGFR，Stat-3和JAK2/3。

GC25000 (E/Z)-BCI

BCI, NSC 150117

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

GC91543 (E/Z)-Droloxifene

3-Hydroxytamoxifen

(E/Z)-Droloxifene is a mixture of (E)-droloxifene, a selective estrogen receptor modulator (SERM), and (Z)-droloxifene.

GC62407 (E/Z)-Eltrombopag 13C

(E/Z)-SB-497115 13C4

(E/Z)-Eltrombopag 13C ((E/Z)-SB-497115 13C4) 是 E-Eltrombopag 和 Z-Eltrombopag 的混合复合物，带有 13C 标记。

GC40833 (E/Z)-Endoxifen

N-去甲基-4-羟基-

An active metabolite of tamoxifen

GC62735 (E/Z)-GO289 (E/Z)-GO289 potently and selectively inhibits casein kinase 2 (CK2) at an IC50 of 7 nM in vitro kinase assay.

GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers, in which GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor with an IC50 of 4.19 nM.