Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC43853Histone H3K36Me3 (21-44)-GK-biotin (trifluoroacetate salt)纯度: >95.00%
A biotinylated peptide fragment of histone H3
- GC43854Histone H3K4Me1 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
Histone H3K4Me1 (1-10) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
- GC43855Histone H3K4Me1 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43856Histone H3K4Me2 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43857Histone H3K4Me2 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43858Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43859Histone H3K79Me3 (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43860Histone H3K9Ac (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43861Histone H3K9Ac (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43862Histone H3K9Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43863Histone H3K9Me3 (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC43864Histone H4 Peptide Substrate (1-21)纯度: >95.00%
Target substrate for several histone modifying enzymes
- GC44401Nicotinamide ribosideCAS: 1341-23-7纯度: >95.00% / >99.50%
烟酰胺核苷是维生素 B3 和 NAD+ 前体的一种形式，通过烟酰胺核苷激酶 (NRK) 和 NMNAT，或通过核苷磷酸化酶和 NAM 补救作用，转化为生物可利用的 NAD+.在体外实验中，烟酰胺核苷通过激活 SirT1/PGC-1α/线粒体生物合成途径减轻酒精引起的肝损伤。
- GC44859S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)CAS: 86867-01-8纯度: >95.00%
Ubiquitous methyl donor
- GC44886S-Farnesyl Thioacetic AcidCAS: 135784-48-4纯度: >97.00%
A competitive inhibitor of SAM-dependent methyltransferase
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC43853 | Histone H3K36Me3 (21-44)-GK-biotin (trifluoroacetate salt) | - | >95.00% | |
A biotinylated peptide fragment of histone H3 | ||||
| GC43854 | Histone H3K4Me1 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3K4Me1 (1-10) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence. | ||||
| GC43855 | Histone H3K4Me1 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43856 | Histone H3K4Me2 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43857 | Histone H3K4Me2 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43858 | Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43859 | Histone H3K79Me3 (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43860 | Histone H3K9Ac (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43861 | Histone H3K9Ac (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43862 | Histone H3K9Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43863 | Histone H3K9Me3 (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC43864 | Histone H4 Peptide Substrate (1-21) | - | >95.00% | |
Target substrate for several histone modifying enzymes | ||||
| GC43865 | Histone H4 Peptide Substrate (15-24) | - | >98.00% | |
Substrate for acceptor peptide SET8 | ||||
| GC43889 | I-CBP112 (hydrochloride) | 2147701-33-3 | >90.00% | |
A p300 and CBP inhibitor | ||||
| GC44184 | Methylstat (hydrate) | - | >98.00% | |
A cell-permeable demethylase inhibitor | ||||
| GC44250 | MS351 | 472984-79-5 | >98.00% | |
MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain. | ||||
| GC44401 | Nicotinamide riboside | 1341-23-7 | >95.00% / >99.50% | |
烟酰胺核苷是维生素 B3 和 NAD+ 前体的一种形式，通过烟酰胺核苷激酶 (NRK) 和 NMNAT，或通过核苷磷酸化酶和 NAM 补救作用，转化为生物可利用的 NAD+.在体外实验中，烟酰胺核苷通过激活 SirT1/PGC-1α/线粒体生物合成途径减轻酒精引起的肝损伤。 | ||||
| GC44477 | NVS-CECR2-1 | 1992047-61-6 | >99.00% | |
A potent and selective CECR2 inhibitor | ||||
| GC44668 | Posaconazole D-Glucuronide | - | >80.00% | |
A metabolite of posaconazole | ||||
| GC44859 | S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) | 86867-01-8 | >95.00% | |
Ubiquitous methyl donor | ||||
| GC44865 | SAHA-BPyne | 930772-88-6 | >98.00% | |
A probe for HDAC activity | ||||
| GC44866 | SAHA-d5 | 1132749-48-4 | >99.00% | |
An internal standard for the quantification of SAHA | ||||
| GC44886 | S-Farnesyl Thioacetic Acid | 135784-48-4 | >97.00% | |
A competitive inhibitor of SAM-dependent methyltransferase | ||||
| GC44984 | TAF 10 Peptide | - | >98.00% | |
A peptide associated with RNA polymerase II activity | ||||