Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC33372PROTAC BRD9 Degrader-1CAS: 2097971-01-0纯度: >98.00%
PROTACBRD9Degrader-1是一种先导PROTACBRD9化学降解剂，可用作研究BAF复合物的选择性探针。
- GC33379Aurora B inhibitor 1CAS: 937276-52-3
AuroraBinhibitor1是一种AuroraB(Aurora-1)抑制剂，Ki值<0.010uM。详细信息请参考专利文献WO2007059299A1中的化合物1-3。
- GC33418PROTAC Sirt2 Degrader-1CAS: 2098487-75-1纯度: >98.50%
PROTACSirt2Degrader-1是一种基于SirReal的PROTAC，为Sirt2的降解剂，由一个高效、同种型选择性的Sirt2抑制剂，一个连接物和thalidomide(E3泛素化连接酶的配体)组成。PROTACSirt2Degrader-1对Sirt2的IC50值为0.25μM，而对Sirt1/Sirt3(IC50>100μM)无作用
- GC34071Pamiparib (BGB-290)CAS: 1446261-44-4纯度: >99.50%
Pamiparib (BGB-290)是一种强效口服的聚腺苷二磷酸核糖聚合酶（PARP）抑制剂，对PARP-1和PARP-2的IC 50 值分别为1.3nM和0.9nM。
- GC34120Niraparib R-enantiomer (MK 4827 (R-enantiomer))CAS: 1038915-58-0纯度: >99.50%
Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂，IC50 为 2.4 nM。
- GC34136EPZ011989 trifluoroacetate (EPZ-011989 trifluoroacetate)CAS: 1598383-41-5
An orally bioavailable EZH2 inhibitor
- GC34160UNC0379 trifluoroacetate (UNC-0379 trifluoroacetate)CAS: 1620401-83-3纯度: >99.00%
A selective SET8 inhibitor
- GC34187Dihydrocoumarin (Hydrocoumarin)CAS: 119-84-6纯度: >98.00%
A coumarin with enzyme inhibitory activity
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC33339 | S 2101 | 1239262-36-2 | - | |
S2101是一个赖氨酸特异性去甲基化酶1(LSD1)抑制剂，其IC50值为0.99μM，Ki值为0.61μM，Kinact/Ki值为4560M/s。 | ||||
| GC33358 | WD2000-012547 | 283172-68-9 | - | |
WD2000-012547是一种选择性的PARP-1抑制剂，pKi为8.221。 | ||||
| GC33363 | MZP-55 | 2010159-48-3 | >99.00% | |
MZP-55是基于PROTAC技术的一种选择性的BRD3/4降解剂，对Brd4BD2的Kd值为8nM。 | ||||
| GC33371 | MOZ-IN-2 | 2055397-88-9 | >98.00% | |
An inhibitor of KAT6A/MOZ | ||||
| GC33372 | PROTAC BRD9 Degrader-1 | 2097971-01-0 | >98.00% | |
PROTACBRD9Degrader-1是一种先导PROTACBRD9化学降解剂，可用作研究BAF复合物的选择性探针。 | ||||
| GC33379 | Aurora B inhibitor 1 | 937276-52-3 | - | |
AuroraBinhibitor1是一种AuroraB(Aurora-1)抑制剂，Ki值<0.010uM。详细信息请参考专利文献WO2007059299A1中的化合物1-3。 | ||||
| GC33382 | JAK3-IN-7 | 1263774-57-7 | - | |
JAK3-IN-7是一种有效的选择性JAK3抑制剂，详细信息请参考专利文献WO2011013785A1中表1-1中的化合物1和2，IC50<0.01μM。 | ||||
| GC33395 | HDAC-IN-5 | 1314890-51-1 | - | |
HDAC-IN-5是组蛋白去乙酰化酶(HDAC)的一个抑制剂。 | ||||
| GC33397 | Valemetostat | 1809336-39-7 | >99.50% | |
A dual EZH1 and EZH2 inhibitor | ||||
| GC33403 | E-7386 | 1799824-08-0 | >98.00% | |
E-7386是一种口服有效的CBP/β-连环蛋白(CBP/beta-catenin)调节剂。 | ||||
| GC33416 | AFP464 | 468719-52-0 | - | |
AFP464（NSC710464 游离碱基），是一个活跃的 HIF-1α；抑制剂，IC50 为 0.25 μM，也是一种有效的芳烃受体 (AhR) 激活剂。 | ||||
| GC33418 | PROTAC Sirt2 Degrader-1 | 2098487-75-1 | >98.50% | |
PROTACSirt2Degrader-1是一种基于SirReal的PROTAC，为Sirt2的降解剂，由一个高效、同种型选择性的Sirt2抑制剂，一个连接物和thalidomide(E3泛素化连接酶的配体)组成。PROTACSirt2Degrader-1对Sirt2的IC50值为0.25μM，而对Sirt1/Sirt3(IC50>100μM)无作用 | ||||
| GC33422 | HAT-IN-1 | 1889281-94-0 | - | |
HAT-IN-1是HAT的抑制剂，用于癌症研究。 | ||||
| GC33634 | Enarodustat (JTZ-951) | 1262132-81-9 | >98.00% | |
A pan HIF-PH inhibitor | ||||
| GC34071 | Pamiparib (BGB-290) | 1446261-44-4 | >99.50% | |
Pamiparib (BGB-290)是一种强效口服的聚腺苷二磷酸核糖聚合酶（PARP）抑制剂，对PARP-1和PARP-2的IC 50 值分别为1.3nM和0.9nM。 | ||||
| GC34078 | I-CBP112 | 1640282-31-0 | >98.00% | |
A p300 and CBP inhibitor | ||||
| GC34108 | CARM1-IN-1 | 1020399-49-8 | - | |
A selective inhibitor of PRMT4/CARM1 | ||||
| GC34120 | Niraparib R-enantiomer (MK 4827 (R-enantiomer)) | 1038915-58-0 | >99.50% | |
Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂，IC50 为 2.4 nM。 | ||||
| GC34136 | EPZ011989 trifluoroacetate (EPZ-011989 trifluoroacetate) | 1598383-41-5 | - | |
An orally bioavailable EZH2 inhibitor | ||||
| GC34138 | M-110 | 1395048-49-3 | >98.50% | |
M-110是Pim激酶抑制剂，抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。 | ||||
| GC34159 | Ilorasertib (ABT-348) | 1227939-82-3 | - | |
A multi-kinase inhibitor | ||||
| GC34160 | UNC0379 trifluoroacetate (UNC-0379 trifluoroacetate) | 1620401-83-3 | >99.00% | |
A selective SET8 inhibitor | ||||
| GC34165 | Corin | 1808113-09-8 | >98.00% | |
Corin是组氨酸赖氨酸特异性去甲基化酶(LSD1)和组氨酸脱乙酰化酶(HDAC)的双重抑制剂，其对LSD1的Ki(inact)值为110nM，对HDAC1的IC50值为147nM。 | ||||
| GC34187 | Dihydrocoumarin (Hydrocoumarin) | 119-84-6 | >98.00% | |
A coumarin with enzyme inhibitory activity | ||||