Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC49093 Safflower Red

红花黄色素
Safflower red是从番红花（Carthamus tinctorius）的花朵中提取的活性物质。
GC38845 sAJM589 sAJM589 是一种 Myc 抑制剂，能干扰 Myc- max 异二聚体的形成，其 IC50 值为 1.8 μM。
GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
GC16289 SAR407899 hydrochloride

6-(哌啶-4-氧基)异喹啉-1(2H)-酮盐酸盐
A ROCK1 and ROCK2 inhibitor
GC46218 Satratoxin G A macrocyclic trichothecene mycotoxin
GC46219 Satratoxin H A trichothecene mycotoxin
GC48069 Saxagliptin-13C-d2 (hydrochloride) A neuropeptide with diverse biological activities
GC11022 SB 218078 A potent Chk1 inhibitor
GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
GC66437 SB-216 SB-216 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂。SB-216 在包括黑色素瘤、肺癌和乳腺癌在内的一系列人类癌症细胞株中显示出很强的抗增殖能力。SB-216 可用于癌症研究。
GC12064 SB1317

14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯,TG02;SB 1317;TG 02;SB-1317;TG-02
A multi-kinase inhibitor
GC14600 SB743921 An Eg5 inhibitor
GC14644 SBE 13 HCl A potent Plk1 inhibitor
GC37601 SBE13 A potent Plk1 inhibitor
GC16614 SCH-1473759

SCH1473759;SCH 1473759
SCH-1473759 是一种极光抑制剂，对极光 A 和 B 的 IC50 分别为 4 和 13 nM。
GC37606 SCH-1473759 hydrochloride SCH-1473759 hydrochloride是多靶点的的极光激酶 (aurora) 抑制剂，对极光激酶A和B的IC50 值分别为4 和13 nM。
GC17792 SCH900776 S-isomer

SCH 900776 S-isomer;SCH-900776 S-isomer
SCH900776 S-异构体是SCH900776的S-异构体。 SCH900776 是一种有效的、选择性的、具有口服生物利用度的检查点激酶1 (Chk1) 抑制剂，IC50 为 3 nM。
GN10091 Schaftoside

夏佛塔苷
A flavonoid C-glycoside with diverse biological activities
GC49674 Schizandrin

五味子醇甲; Schizandrin; Schizandrol; Schizandrol-A
A lignan with diverse biological activities
GC39798 Scoulerine

金黄紫堇碱,(-)-Scoulerine; Discretamine
A benzylisoquinoline alkaloid with diverse biological activities
GC91279 scyllo-Inositol hexakisphosphate (sodium salt)

scyllo-IP6

IP6的立体异构体
GC45562 scyllo-Inositol hexakisphosphate (sodium salt)

scylloIP6
A stereoisomer of IP₆
GC49723 SenTraGor™ Cell Senescence Reagent

GL13, SBB-A-B, SBB-Analogue (GL13) Biotin

A cellular senescence detection reagent
GC48076 Sesquicillin A

Sesquicillin
A fungal metabolite
GC10019 SF1670 SF1670是一种有效的特异性PTEN（第10号染色体上缺失的磷酸酶和张力蛋白同源物）抑制剂。
GC19849 SGC3027 A prodrug form of SGC8158
GC90779 Shepherdin (trifluoroacetate salt)

Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH, Survivin (79-87)

一种抑制survivin-Hsp90相互作用的物质
GC49713 SIKVAV (acetate)

Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val
A laminin α1-derived peptide
GC49002 Sinigrin (hydrate)

黑芥子硫苷酸钾一水；芥子甙单水合物
A glucosinolate with diverse biological activities
GC64539 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
GC12827 SLx-2119

2-[3-[4-[(1H-吲唑-5-基)氨基]喹唑啉-2-基]苯氧基]-N-异丙基乙酰胺,SLx 2119;SLx2119;ROCK inhibitor;KD-025
A ROCK2 inhibitor
GC11396 SNS-032 (BMS-387032)

BMS-387032
A Cdk2, Cdk7, and Cdk9 inhibitor
GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
GC13837 SNS-314 Mesylate

N-(3-氯苯基)-N'-[5-[2-(噻吩并3,2-D]嘧啶-4-基氨基)乙基]-2-噻唑基]脲甲磺酸盐(1:1)
A pan-Aurora kinase inhibitor
GC32935 Soblidotin (Auristatin PE)

Auristatin PE; TZT-1027
Soblidotin (Auristatin PE) (Auristatin PE) 是一种新型合成的 Dolastatin 10 衍生物和微管蛋白聚合抑制剂。
GC48084 Sodium 4-Phenylbutyrate-d11

4-PBA-d11 sodium; 4-Phenylbutyric acid-d11 sodium; Benzenebutyric acid-d11 sodium
An internal standard for the quantification of sodium 4-phenylbutyrate
GC91041 Soluble Epoxide Hydrolase PROTAC 1a

sEH PROTAC 1a, sEH Proteolysis-targeting Chimera 1a, Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a

一种促进sEH降解的PROTAC
GC65887 SOP1812 SOP1812 是一种 naphthalene diimide (ND) 衍生物，具有抗肿瘤活性。SOP1812 能够与quadruplex arrangements (G4s) 结合，并下调多个癌症基因通路。SOP1812 对 hTERT G4 和 HuTel21 具有很强的亲和力，其 KD 值分别为 4.9 和 28.4 nM。G4SOP1812 可用于癌症的研究。
GC63351 Sovesudil

PHP-201; AMA0076
Sovesudil (PHP-201) 是一种有效的、ATP 竞争性局部作用 Rho激酶 (ROCK) 抑制剂，对 ROCK I 和 ROCK II 的 IC50 分别为 3.7 和 2.3 nM。Sovesudil 降低眼压而不引起充血。
GC63716 Sovesudil hydrochloride

PHP-201 hydrochloride; AMA0076 hydrochloride
Sovesudil (PHP-201) hydrochloride 是一种有效的、ATP 竞争性局部作用 Rho 激酶 (ROCK) 抑制剂，对 ROCK I 和 ROCK II 的 IC50 分别为 3.7和2.3 nM。Sovesudil hydrochloride 可降低眼压而不引起充血。
GC64019 Sovilnesib

AMG 650
AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.
GC61286 SP-8356 SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
GC73230 SP27 SP27是一种能够选择性降解PLK4的PROTAC，其DC50为19.5 nM。
GC48090 Sphingosine-d9 (d18:1)

D-erythro-Sphingosine C18-d9
A neuropeptide with diverse biological activities
GC48092 Spinosad

LY232105, XDE-105
A naturally-occurring insecticide
GC41258 Spiroxamine

螺噁茂胺
A fungicide
GC91208 Spiroxamine-d4
一种用于测量斯比洛克胺的内部标准
GC44946 Sporidesmolide III A cyclodepsipeptide
GC50043 SR 3677 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC10722 SR-3677

N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
A ROCK1 and ROCK2 inhibitor