Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC31049 RWJ-51204 RWJ-51204是GABA(A)receptor的部分激动剂，Ki值为0.2-2nM。
GC48063 S 14506 A 5-HT_1A receptor agonist
GC18013 S 14506 hydrochloride A 5-HT_1A receptor agonist
GC13684 S 18986 A positive allosteric modulator of AMPA receptors
GC15910 S 24795

2-[2-(4-溴苯肼)-2-乙氧基]-1-甲基碘吡啶
S 24795 是 α7 nAChR 的部分激动剂，可改善老年小鼠的记忆功能，用于治疗与衰老相关的记忆障碍。
GC31105 S 38093 S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.
GC30027 S-(+)-Marmesin ((+)-Marmesin)

异紫花前胡内酯,(+)-Marmesin; (S)-Marmesin
A coumarin with anticancer activity
GC18650 S-(5'-Adenosyl)-L-methionine (tosylate)

AdoMet, SAM, SAMe

S-Adenosyl-L-methioninetosylate(S-Adenosylmethioninetosylate)是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和ATP内源性生产的，是一种重要的具有口服活性的甲基供体。
GC31835 S-2474 S-2474是COX-2和5-lipoxygenase的抑制剂，在人完整的细胞中，对COX-2和COX-1的IC50值分别为11nM和27μM，为一种非甾体抗炎药。
GC31121 S-8510 phosphate (SB-737552 phosphate)

SB-737552 phosphate
S-8510 (phosphate) 是一种反向苯二氮卓 (BDZ) 受体激动剂，对 -GABA 和 +GABA 的 Kis 分别为 34.6 nM、36.2 nM。
GC52033 S-Methyl-D-penicillamine A metabolite of D-penicillamine
GC10026 S-Sulfo-L-cysteine sodium salt EAA receptor agonist
GC31313 S16961 (S169611)

S169611
S16961 (S169611) 是一种烟碱受体激动剂。
GC90638 S1H (trifluoroacetate salt)

Site 1-binding Helix

一种生长激素受体的合成肽拮抗剂
GC69852 Sabcomeline hydrochloride

SB-202026 hydrochloride; Memric hydrochloride
Sabcomeline (SB-202026) hydrochloride 是一种有效的功能性选择性 M1 毒蕈碱受体受体 ( muscarinic M1 receptor) 部分激动剂，可以改善认知功能。Sabcomeline hydrochloride 可用于阿尔茨海默症的研究。
GC49093 Safflower Red

红花黄色素
Safflower red是从番红花（Carthamus tinctorius）的花朵中提取的活性物质。
GC13016 Safinamide

沙芬酰胺; FCE 26743; EMD 1195686
Safinamide 是一种强效、选择性和可逆的单胺氧化酶 B (MAO-B) 抑制剂 (IC50=0.098 μM)，优于 MAO-A (IC50=580 μM)。
GC49756 Safinamide Acid

沙芬酰胺杂质5
A potential impurity found in commercial preparations of safinamide
GC90480 Safinamide Metabolite NW 1689
商业制备的沙非胺中发现了潜在杂质。
GC45557 Safinamide-d4

沙芬酰胺 d4
An internal standard for the quantification of safinamide
GC19318 SAGE-217

S-812217, SGE 797
A positive allosteric modulator of GABA_A receptors
GN10502 Saikosaponin C

柴胡皂苷 C
A saikosaponin with anti-inflammatory and analgesic activities
GC48374 Saikosaponin D (hydrate) A triterpene saponin with diverse biological activities
GC16508 Salicylic acid

水杨酸; 2-Hydroxybenzoic acid
An Analytical Reference Standard
GC74187 Salicylic acid-13C6

2-Hydroxybenzoic acid-13C6
Salicylic acid-13C6是13c标记的水杨酸。
GC49480 Salicylic Acid-d4

水杨酸-D4
An internal standard for the quantification of salicylic acid
GC64032 Salicylic acid-d6

水杨酸-D6; 2-Hydroxybenzoic acid-d6
Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) 是 Salicylic acid 的一种氘代化合物。Salicylic acid 抑制 COX-2 活性，抑制作用与转录因子 (NF-κB) 激活无关。
GC49363 Salicyluric Acid

2-羟基马尿酸
A major metabolite of aspirin and salicylic acid
GC33749 Salsolidine

猪毛菜定；鹿尾草定
An alkaloid
GC11269 Salsolinol-1-carboxylic acid Salsolinol-1-carboxy acid 是中枢神经系统 (CNS) 中的一种内源性生物碱。
GC44869 Salvinorin A Carbamate A potent KOR agonist
GC44870 Salvinorin A Propionate

Salvinorinyl-2-propionate
A selective κ₁-opioid receptor partial agonist
GC44871 Salvinorin B Mesylate

Mesyl Sal B
A κ-opioid receptor agonist
GC64084 Samelisant

SUVN-G3031
Samelisant (SUVN-G3031) 是一种口服有效的，可通过血脑屏障的选择性组胺 H3 受体 (H3R) 反向激动剂。Samelisant 对人类 (hH3R; Ki=8.7 nM) 和大鼠 (rH3R; Ki=9.8 nM) H3R 具有相似的结合亲和力，表明没有种间差异。 Samelisant 可用于研究睡眠相关疾病。
GC48351 Saralasin (trifluoroacetate salt)

Aralasin, 1-Sar-8-Ala-Angiotensin II
A peptide AT₂ receptor agonist
GC31143 Saredutant (SR 48968)

SR 48968; SR 48968C
Saredutant (SR 48968) 是一种选择性（Neurokinin 2） NK2受体拮抗剂，IC₅₀值为0.13nM。
GC64530 Sarizotan

EMD 128130
Sarizotan (EMD 128130) 是具有口服活性的 5-HT1A 受体和多巴胺受体的激动剂，其 IC50 值分别为 6.5 nM (rat 5-HT1A)、 0.1 nM (human 5-HT1A)、15.1 nM (rat D2)、17 nM (human D2)、6.8 nM (human D3) 和 2.4 nM (human D4.2)。
GC31112 Sarmazenil (Ro 15-3505)

沙马西尼,Ro 15-3505
Sarmazenil (Ro 15-3505) 是一种苯二氮卓受体拮抗剂。
GC16202 Sarpogrelate hydrochloride

盐酸沙格雷酯; MCI-9042
A selective 5-HT₂ receptor antagonist
GC49679 Sauvagine (trifluoroacetate salt) A neuropeptide hormone
GC14342 Sazetidine A dihydrochloride α4β2 nicotinic acetylcholine receptor ligand
GC25898 SB 200646

SB 200646A
SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
GC18273 SB 202190 (hydrochloride) A potent and selective p38 MAP kinase inhibitor
GC50014 SB 215505

6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺
SB 215505 是一种有效的亚型选择性 5-HT2B 受体拮抗剂，对 5-HT2B、5-HT2A、5-HT2C 的 pKi 值分别为 8.3、6.77、7.66。
GC13438 SB 224289 hydrochloride

SB-224289A
A 5-HT_1B receptor inverse agonist
GC14392 SB 242084

6-氯-2,3-二氢-5-甲基-N-[6-[(2-甲基-3-吡啶基)氧]-3-吡啶基]-1H-吲哚-1-酰胺盐酸盐
Specific antagonist of 5-HT_2C
GC61268 SB 243213 A 5-HT_2C receptor inverse agonist
GC37596 SB 258719 SB 258719 是一个有选择性的 5-HT7 受体拮抗剂，其 pKi 值为 7.5。
GC37597 SB 271046 Hydrochloride

5-氯-N-[4-甲氧基-3-(1-哌嗪基)苯基]-3-甲基苯并[B]噻吩-2-磺酰胺盐酸盐,SB 271046A
An orally-available 5-HT₆ antagonist
GC13183 SB 277011A dihydrochloride

SB-277011A dihydrochloride
A selective dopamine D₃ antagonist