Adrenomedullin (11-50) is a truncated form of rat adrenomedullin.1,2 Intravenous administration of adrenomedullin (11-50) (3-10 μg/animal) decreases mean systemic arterial pressure in rats in a dose-dependent manner without affecting cardiac output.1 Cerebroventricular injection of adrenomedullin (11-50) (88 pmol) reduces water intake in response to angiotensin II , overnight water deprivation, and hyperosmotic challenge in rats.2
1.Lin, B., Gao, Y., Chang, J.K., et al.An adrenomedullin fragment retains the systemic vasodepressor activity of rat adrenomedullinEur. J. Pharmacol.260(1)1-4(1994) 2.Murphy, T.C., and Samson, W.K.The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the ratEndocrinology136(6)2459-2469(1995)