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Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

研究方向

Neuroscience 相关产品(3932)

  • GC61337 structure
    GC61337Tolmetin
    CAS: 26171-23-3
    纯度: >99.00%

    Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.

  • GC61367 structure
    GC61367VAF347
    CAS: 574759-62-9
    纯度: >99.50%

    VAF347是一种细胞可渗透且高度亲和力的芳烃受体(AhR)激动剂，可诱导AhR信号传导。VAF347抑制颗粒单核细胞(GM期)前体中CD14+CD11b+单核细胞的发育。VAF347具有抗炎作用。

  • GC61371 structure
    GC61371Veratric acid
    CAS: 1993-7-2
    纯度: >99.50%

    Veratricacid(3,4-Dimethoxybenzoicacid)是从蔬菜和水果中得到的多酚物质，可口服，具有抗氧化、保护心血管和抗炎活性。当细胞受到UVB辐射时，Veratricacid能够减少上调的COX-2表达，降低PGE2和IL-6水平。

  • GC61377 structure
    GC61377VU0119498
    CAS: 79183-37-2
    纯度: >99.50%

    An M 1 , M 3 , and M 5 muscarinic receptor positive allosteric modulator

  • GC61378 structure
    GC61378VU0238441
    CAS: 85511-68-8

    VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50 of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and >10 μM for M5, M3, M2, M1 and M4, respectively.

  • GC61382 structure
    GC61382Xanthoangelol
    CAS: 62949-76-2
    纯度: >98.00%

    Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.

  • GC61387 structure
    GC61387Zamifenacin
    CAS: 127308-82-1
    纯度: >99.50%

    A muscarinic M 3 receptor antagonist

  • GC61389 structure
    GC61389Ziprasidone amino acid
    CAS: 1159977-64-6

    Ziprasidoneaminoacid(ZiprasidoneImpurityC)是Ziprasidone的杂质。Ziprasidone是5-HT和多巴胺(dopaminereceptor)受体拮抗剂，具有抗精神病活性。

  • GC61401 structure
    GC61401Oxatomide
    CAS: 60607-34-3
    纯度: >99.00%

    Oxatomide是一种口服活性的H1受体拮抗剂（抗组胺药）。

  • GC61436 structure
    GC61436Gallic acid hydrate
    CAS: 5995-86-8
    纯度: >98.00%

    A phenol with diverse biological activities

  • GC61446 structure
    GC61446(Rac)-Lanicemine
    CAS: 61890-25-3
    纯度: >99.50%

    (Rac)-Lanicemine((Rac)-AZD6765)是Lanicemine的外消旋体。Lanicemine(AZD6765)是一种低捕获的NMDA受体拮抗剂，Ki为0.56-2.1 μM。CHO和爪蟾卵母细胞中，IC50分别为4-7μM和6.4μM。具有抗抑郁作用。

  • GC61453 structure
    GC61453Penconazole
    CAS: 66246-88-6
    纯度: >99.00%

    Penconazole是一种典型的三唑类杀菌剂(fungicide)，主要用于苹果、葡萄、蔬菜等地的白粉病防治。Penconazole抑制真菌固醇生物合成。Penconazole降低大鼠大脑和小脑AChE活性。

  • GC61464 structure
    GC61464GR 125743
    CAS: 148547-33-5
    纯度: >99.50%

    GR125743是一种选择性的5-HT1B/1D受体拮抗剂，与野生型的人h5-HT1B和5-HT1D结合的pKi分别为8.85和8.31。GR125743可用于帕金森病和心血管疾病的研究。

  • GC61467 structure
    GC61467Niaprazine
    CAS: 27367-90-4
    纯度: >98.50%

    Niaprazine是一种具有强效镇静作用的组胺H1受体(histamineH1-receptor)拮抗剂。Niaprazine具有抗组胺和抗血清素活性，并可用于睡眠障碍的研究。

  • GC61476 structure
    GC61476Fmoc-Ala-Glu-Asn-Lys-NH2
    CAS: 220701-06-4
    纯度: >98.00%

    Fmoc-Ala-Glu-Asn-Lys-NH2是一种选择性天冬酰胺内肽酶AEP抑制肽，可抑制淀粉样前体蛋白APP裂解。AEP是一种pH值控制的半胱氨酸蛋白酶，在衰老过程中被激活并介导APP蛋白水解过程。

  • GC61486 structure
    GC61486Neurokinin A TFA
    CAS: 2828433-19-6
    纯度: >99.00%

    Neurokinin A TFA是一种内源性的速激肽家族神经肽，是神经激肽2受体（NK2R）的强效选择性激动剂。

  • GC61521 structure
    GC61521Calmodulin-Dependent Protein Kinase II(290-309) acetate
    纯度: >98.50%

    Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。

  • GC61539 structure
    GC61539Betazole
    CAS: 105-20-4
    纯度: >99.00%

    Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.

  • GC61565 structure
    GC61565Indophagolin
    CAS: 1207660-00-1
    纯度: >98.00%

    Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.

  • GC61566 structure
    GC61566Pseudocoptisine chloride
    CAS: 30044-78-1
    纯度: >99.00%

    Pseudocoptisine chloride (Isocoptisine chloride) is a quaternary alkaloid with benzylisoquinoline skeleton isolated from Corydalis Tuber, inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM, showing anti-inflammatory and anti-amnestic effects.

  • GC61570 structure
    GC61570Sepimostat dimethanesulfonate
    CAS: 103926-82-5

    Sepimostatdimethanesulfonate(FUT-187)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostatdimethanesulfonate抑制Ifenprodil结合的Ki值为27.7 µM。

  • GC61580 structure
    GC61580Sepimostat
    CAS: 103926-64-3
    纯度: >99.50%

    Sepimostat(FUT-187freebase)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostat抑制Ifenprodil结合的Ki值为27.7 µM。

  • GC61593 structure
    GC61593DAPK Substrate Peptide TFA
    纯度: >99.00%

    DAPKSubstratePeptideTFA是一种合成的死亡相关蛋白激酶(DAPK)的肽底物，Km为9μM。

  • GC61624 structure
    GC61624Lesogaberan
    CAS: 344413-67-8

    Lesogaberan(AZD-3355)是一种有效的选择性GABAB受体激动剂，对人重组GABAB受体的EC50为8.6nM。对大鼠脑GABAB和GABAA受体的结合亲和力(Ki)分别为5.1nM和1.4μM。