Prolactin-Releasing Peptide (1-31) (human) (trifluoroacetate salt)
(Synonyms: Human PrRP-31; PrRP (1-31)) 目录号 : GC92195
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Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.
Sample solution is provided at 25 µL, 10mM.
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Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake. It is found in the pothalamus, medulla, and pituitary in rats. PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively). It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM). PrRP (100 nM) increases the release of gonadotropin-releasing hormone , vasoactive intestinal peptide , and galanin from rat medial basal pothalamic explants. It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol. PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.
| Cas No. | SDF | ||
| 别名 | Human PrRP-31; PrRP (1-31) | ||
| 化学名 | L-seryl-L-arginyl-L-threonyl-L-histidyl-L-arginyl-L-histidyl-L-seryl-L-methionyl-L-α-glutamyl-L-isoleucyl-L-arginyl-L-threonyl-L-prolyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-prolyl-L-alanyl-L-tryptophyl-L-tyrosyl-L-alanyl-L-seryl-L-arginylglycyl-L-isoleucyl-L-arginyl-L-prolyl-L-valylglycyl-L-arginyl-L-phenylalaninamide, trifluoroacetate salt | ||
| Canonical SMILES | NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H]3CCCN3C([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CO)N[H])=O)=O)=O)CC4=CN=CN4)=O)=O)CC5=CN=CN5)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)C)=O)CC6=CNC7=C6C=CC=C7)=O)CC8=CC=C(O)C=C8)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=CC=C9)=O.FC(F)(F)C(O)=O | ||
| 分子式 | C160H252N56O42S • XCF3COOH | 分子量 | 3664.186 |
| 溶解度 | Water: 1 mg/ml | 储存条件 | -20°C |
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 272.9 μL | 1.3646 mL | 2.7291 mL |
| 5 mM | 54.6 μL | 272.9 μL | 545.8 μL |
| 10 mM | 27.3 μL | 136.5 μL | 272.9 μL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A lyophilized powder
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet