GlpBio

DNA Damage/DNA Repair

DNA Damage/DNA Repair(DNA损伤/DNA修复)

研究方向

DNA Damage/DNA Repair 相关产品(1788)

  • GC52165 structure
    GC52165Minosaminomycin
    CAS: 51746-09-9
    纯度: >90.00%

    An antibiotic

  • GC52171 structure
    GC52171Clindamycin-d3 (hydrochloride)
    CAS: 1356933-72-6
    纯度: >99.00%

    An internal standard for the quantification of clindamycin

  • GC52183 structure
    GC521832'-O-Methyl-5-methyluridine
    CAS: 55486-09-4
    纯度: >98.00%

    A modified nucleoside

  • GC52303 structure
    GC52303Ethyl Mycophenolate
    CAS: 32483-51-5
    纯度: >98.00%

    A potential impurity found in commercial preparations of mycophenolate mofetil

  • GC52351 structure
    GC52351Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide

    A biotinylated and citrullinated α-enolase peptide

  • GC52391 structure
    GC52391306-O12B-3
    CAS: 2982842-90-8
    纯度: >95.00%

    An ionizable cationic lipidoid

  • GC52455 structure
    GC52455Pixantrone-d8 (maleate)
    纯度: >99.00%

    An internal standard for the quantification of pixantrone

  • GC52513 structure
    GC52513Indolimine-214
    纯度: >98.00%

    A genotoxic gut microbiota metabolite

  • GC52516 structure
    GC52516Erbstatin
    CAS: 100827-28-9
    纯度: >90.00%

    A tyrosine kinase inhibitor

  • GC60023 structure
    GC600233'-Deoxyuridine-5'-triphosphate
    CAS: 69199-40-2
    纯度: >98.00%

    3'-Deoxyuridine-5'-triphosphate(3'-dUTP)是一种核苷酸类似物，可抑制DNA依赖性RNA聚合酶I和II(RNApolymerasesI和II)，强烈并竞争性地抑制UTP掺入到RNA中，Ki值为2.0μM。

  • GC60031 structure
    GC600316-Azathymine
    CAS: 932-53-6
    纯度: >98.00%

    6-Azathymine，胸腺嘧啶的6-氮类似物，是一种有效的D-3-氨基异丁酸酯-丙酮酸氨基转移酶(D-3-aminoisobutyrate-pyruvateaminotransferase)抑制剂。6-Azathymine可抑制DNA的生物合成，并具有抗菌和抗病毒活性。

  • GC60037 structure
    GC60037A-3 hydrochloride
    CAS: 78957-85-4
    纯度: >99.50%

    A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.

  • GC60062 structure
    GC60062AV-153 free base
    CAS: 19350-66-4
    纯度: >98.50%

    AV-153 free base 是一种 1,4-dihydropyridine (1,4-DHP) 衍生物，具有抗突变作用。在体外人细胞内，AV-153 free base 可以插入到 DNA 的单链断裂处，减少 DNA 损伤并刺激 DNA 修复。AV-153 free base 可以与胸腺嘧啶和胞嘧啶相互作用，对聚 (ADP) 核糖基化有影响。AV-153 free base 具有抗癌活性。

  • GC60089 structure
    GC60089Bleomycin hydrochloride
    CAS: 67763-87-5
    纯度: >98.00%

    Bleomycinhydrochloride是一种DNA损伤剂，抑制DNA合成。Bleomycinhydrochloride是一种抗肿瘤抗生素(antibiotic)。

  • GC60107 structure
    GC60107Chloroquinoxaline sulfonamide
    CAS: 97919-22-7
    纯度: >99.00%

    Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是 sulfaquinoxaline 的结构类似物，是拓扑异构酶 II alpha/beta (topoisomerase II alpha/beta) 毒物。Chloroquinoxaline sulfonamide 用于控制家禽，兔，绵羊和牛的球虫病。 具有抗肿瘤活性。

  • GC60234 structure
    GC60234Maleic hydrazide
    CAS: 123-33-1
    纯度: >99.50%

    Maleichydrazide广泛用作植物生长调节剂和除草剂。Maleichydrazide是核酸和蛋白质合成的抑制剂。

  • GC60268 structure
    GC60268Neoxanthin
    CAS: 14660-91-4

    Neoxanthin是深绿色多叶蔬菜中的一种主要的叶黄素类胡萝卜素，是一种植物激素脱落酸的前体。Neoxanthin是一种有效的抗氧化剂和集光颜料，诱导细胞凋亡(apoptosis)并具有抗癌作用。

  • GC60310 structure
    GC60310Psammaplin A
    CAS: 110659-91-1
    纯度: >96.00%

    PsammaplinA是一种海洋代谢产物，是HDAC和DNA甲基转移酶(DNAmethyltransferases)的有效抑制剂。PsammaplinA是一种高效的选择性HDAC1抑制剂，IC50为0.9nM，对HDAC1的选择性是DAC6的360倍，对HDAC7和HDAC8的效力低1000倍以上。PsammaplinA对革兰氏阳性细菌(Gram-positivebacteria)具有抗菌作用，并抑制DNA合成和DNA促旋酶(DNAgyrase)活性。抗肿瘤活性。

  • GC60317 structure
    GC60317RA-9
    CAS: 919091-63-7
    纯度: >98.00%

    RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.

  • GC60324 structure
    GC60324Ribociclib D6
    CAS: 1328934-40-2

    RibociclibD6(LEE011D6)是Ribociclib的一种氘代化合物。Ribociclib是一种高度特异性的CDK4/6抑制剂，IC50值分别为10nM和39nM，对cyclinB/CDK1复合体的活性低于其1000倍。

  • GC60374 structure
    GC60374Trovafloxacin
    CAS: 147059-72-1
    纯度: >98.50%

    A topoisomerase IV and DNA gyrase inhibitor

  • GC60421 structure
    GC60421(S)-Seco-Duocarmycin SA
    CAS: 152785-82-5
    纯度: >99.00%

    (S)-Seco-DuocarmycinSA是一种DNA烷化剂(DNAalkylator)，可作为抗体药物偶联物的毒素部分(ADCcytotoxin)起作用。

  • GC60459 structure
    GC604592,4-D (2,4-Dichlorophenoxyacetic acid)
    CAS: 94-75-7

    A plant growth regulator

  • GC60532 structure
    GC605326-(Dimethylamino)purine
    CAS: 938-55-6
    纯度: >98.00%

    6-Dimethylaminopurine (N,N-Dimethyladenine) is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes.