GlpBio

ATM/ATR

ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.

ATM/ATR 相关产品(29)

  • GC10196 structure
    GC10196ETP-46464
    CAS: 1345675-02-6
    纯度: >98.00%

    An ATR inhibitor

  • GC10293 structure
    GC10293VE-821
    CAS: 1232410-49-9
    纯度: >98.50%

    An inhibitor of ATR

  • GC14526 structure
    GC14526CGK733
    CAS: 905973-89-9
    纯度: >99.50%

    An anticancer compound

  • GC14949 structure
    GC14949AZ20
    CAS: 1233339-22-4
    纯度: >99.50%

    A potent, selective ATR inhibitor

  • GC15337 structure
    GC15337Berzosertib (VE-822)
    CAS: 1232416-25-9

    Berzosertib (VE-822)是一种静脉给药的、高度强效且选择性的ATR抑制剂(IC 50 =19nM)。

  • GC16489 structure
    GC16489CP-466722
    CAS: 1080622-86-1
    纯度: >99.50%

    An ATM kinase inhibitor

  • GC11118 structure
    GC11118KU 55933
    CAS: 587871-26-9
    纯度: >99.50%

    KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，K i 值为2.2nM。

  • GC11593 structure
    GC11593AZD0156
    CAS: 1821428-35-6
    纯度: >98.00%

    An ATM kinase inhibitor

  • GC12054 structure
    GC12054KU-60019
    CAS: 925701-46-8
    纯度: >98.50% / >98.00%

    A potent ATM kinase inhibitor

  • GC16941 structure
    GC16941AZD6738
    CAS: 1352226-88-0
    纯度: >98.50%

    AZD6738是一种具有口服活性和高效选择性的共济失调毛细血管扩张和Rad3相关蛋白（ATR）激酶抑制剂，IC 50 值为1nM。

  • GC19047 structure
    GC19047AZ32
    CAS: 2288709-96-4
    纯度: >99.50%

    An ATM kinase inhibitor

  • GC19468 structure
    GC19468AZD1390
    CAS: 2089288-03-7
    纯度: >99.50%

    AZD1390是一种新型选择性共济失调毛细血管扩张突变激酶抑制剂，能够高效穿透血脑屏障。

  • GC25372 structure
    GC25372Elimusertib (BAY-1895344) hydrochloride

    Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.

  • GC33404 structure
    GC33404KU 59403
    CAS: 845932-30-1
    纯度: >98.50%

    KU59403是ATM的一个有效抑制剂，其IC50值为3nM。

  • GC33420 structure
    GC33420BAY-1895344
    CAS: 1876467-74-1
    纯度: >99.50%

    An ATR inhibitor

  • GC34374 structure
    GC34374BAY-1895344 hydrochloride

    An ATR inhibitor

  • GC34999 structure
    GC34999(S)-Ceralasertib
    CAS: 1352226-87-9

    (S)-Ceralasertib 从专利 WO2011154737A1 中获取，化合物 II，IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂，具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善，并且消除 CYP3A4 时间依赖性抑制。

  • GC50424 structure
    GC50424AZ 5704
    CAS: 1941214-06-7

    Potent and selective ATM kinase inhibitor; orally bioavailable

  • GC62108 structure
    GC62108Elimusertib hydrochloride
    纯度: >99.50%

    Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。

  • GC64278 structure
    GC64278RP-3500
    CAS: 2417489-10-0

    RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.

  • GC64539 structure
    GC64539SKLB-197
    CAS: 2713577-16-1
    纯度: >99.00%

    SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

  • GC64938 structure
    GC64938AZD-7648
    CAS: 2230820-11-6
    纯度: >99.50%

    An inhibitor of DNA-PK

  • GC65327 structure
    GC65327ATM Inhibitor-5
    CAS: 2495096-26-7

    M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.

  • GC65514 structure
    GC65514ATR inhibitor 1
    CAS: 1613200-51-3

    ATR inhibitor 1 是一种 ATR 抑制剂，Ki 值低于 1 µμ，详细信息请参考专利 WO2015187451A1，化合物 I-l。