GlpBio

Deubiquitinase

Deubiquitinase(去泛素化酶)

Deubiquitinases (DUBs) are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate thecellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases. DUBs play several roles in the ubiquitin pathway. One of the best characterised functions of DUBs is the removal of monoubiqutin and polyubiquitin chainsfrom proteins.

Deubiquitinase 相关产品(76)

  • GC10356 structure
    GC10356DUBs-IN-3
    CAS: 924296-17-3
    纯度: >99.00%

    DUBs-IN-3 是一种有效的去泛素酶 (USP) 酶抑制剂，从参考化合物 22c 中提取，对 USP8 的 IC50 为 0.56 μM。

  • GC10379 structure
    GC10379P 22077
    CAS: 1247819-59-5
    纯度: >98.00%

    P 22077 是一种可渗透细胞的泛素特异性蛋白酶 7 (USP7) 抑制剂，EC50 为 8.01 μM。 P 22077 还抑制 USP47，EC50 为 8.74 μM。

  • GC10510 structure
    GC10510LDN 57444
    CAS: 668467-91-2

    LDN 57444是一种小分子抑制剂，可阻断UCHL1的去泛素化酶活性（K i =0.40μM；IC 50 =0.88μM），抑制UCHL3的IC 50 值为25μM。

  • GC10970 structure
    GC10970WP1130
    CAS: 856243-80-6
    纯度: >99.50%

    A deubiquitinase inhibitor

  • GC12067 structure
    GC12067P005091
    CAS: 882257-11-6
    纯度: >99.50%

    P005091是一种有效的选择性泛素特异性蛋白酶7 (USP7) 抑制剂，EC50 值为4.2 μM。

  • GC12475 structure
    GC12475NSC 632839 hydrochloride
    CAS: 157654-67-6
    纯度: >98.50%

    A deubiquitylase and deSUMOylase inhibitor

  • GC13013 structure
    GC13013TCID
    CAS: 30675-13-9
    纯度: >99.50%

    A potent, selective inhibitor of UCH-L3

  • GC13035 structure
    GC13035Bay 11-7821
    CAS: 19542-67-7
    纯度: >99.50% / >95.00%

    Bay 11-7821是一种IκBα磷酸化和NF-κB抑制剂，选择性且不可逆地抑制TNF-α诱导的IκB-α磷酸化（IC 50 值约为10μM），并减少NF-κB和粘附分子的表达。Bay 11-7821抑制泛素特异性蛋白酶USP7和USP21，IC 50 分别为0.19、0.96μM。

  • GC13208 structure
    GC13208PR-619
    CAS: 2645-32-1
    纯度: >98.50% / >98.00%

    PR-619是一种广谱的去泛素酶抑制剂。

  • GC13401 structure
    GC13401SJB3-019A
    CAS: 2070015-29-9
    纯度: >97.00%

    SJB3-019A是一种新颖的、有效的USP1抑制剂，对K562细胞USP1的IC₅₀为0.0781μM。

  • GC13892 structure
    GC13892C527
    CAS: 192718-06-2
    纯度: >99.50%

    An inhibitor of the USP1/UAF complex

  • GC14366 structure
    GC14366Thioguanine
    CAS: 154-42-7
    纯度: >99.00% / >98.00%

    Thioguanine是一种抗白血病和免疫抑制剂，对重组USP2和冠状病毒PLpro的IC 50 值分别为40μM和25μM。

  • GC14797 structure
    GC14797IU1
    CAS: 314245-33-5
    纯度: >99.00% / >98.00%

    IU1是一种细胞可渗透的、可逆的选择性蛋白酶体抑制剂，对USP14的 IC 50 为 4.7μM。

  • GC15503 structure
    GC15503NSC 687852 (b-AP15)
    CAS: 1009817-63-3
    纯度: >98.50%

    An inhibitor of the deubiquitinases USP14 and UCHL5

  • GC17125 structure
    GC17125DUBs-IN-2
    CAS: 924296-19-5
    纯度: >98.50% / >98.00%

    DUBs-IN-2是一种高度选择性且具有细胞膜渗透性的 USP8 抑制剂，IC 50 值为0.28μM。

  • GC17635 structure
    GC17635ML-323
    CAS: 1572414-83-5
    纯度: >99.50%

    ML-323是一种可逆性强、高效的USP1-UAF1的选择性抑制剂，IC 50 值为76nM。ML-323对游离酶的Ki值为68nM。

  • GC17698 structure
    GC17698SJB2-043
    CAS: 63388-44-3
    纯度: >99.00%

    An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PL pro

  • GC18160 structure
    GC18160USP7/USP47 inhibitor
    CAS: 1247825-37-1
    纯度: >98.00%

    A dual inhibitor of USP7 and USP47

  • GC19378 structure
    GC19378VLX1570
    CAS: 1431280-51-1
    纯度: >98.00%

    VLX1570 is an inhibitor of 19S proteasomal deubiquitinases

  • GC32720 structure
    GC32720ML364
    CAS: 1991986-30-1
    纯度: >99.50%

    An inhibitor of USP2

  • GC32727 structure
    GC32727GNE-6776
    CAS: 2009273-71-4
    纯度: >98.00%

    GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively.

  • GC32786 structure
    GC32786FT671
    CAS: 1959551-26-8
    纯度: >98.00%

    FT671是一种是有效的选择性泛素特异性蛋白酶7（USP7）抑制剂，IC 50 值为52nM。

  • GC32856 structure
    GC32856GNE-6640
    CAS: 2009273-67-8
    纯度: >99.50%

    An inhibitor of USP7

  • GC32917 structure
    GC32917FT827
    CAS: 1959537-86-0
    纯度: >98.50%

    FT827是选择性和共价的泛素特异性蛋白酶7(USP7)抑制剂，IC50值为52nM。