GlpBio

DNA-PK

DNA-PK(DNA依赖蛋白激酶)

DNA-PK is a serine/threonine kinase and acts a molecular sensor for DNA damage. It is involved in NHEJ (non-homologous end joining) for DSB (DNA double strand break) repair and V(D)J recombination.

DNA-PK 相关产品(31)

  • GC10196 structure
    GC10196ETP-46464
    CAS: 1345675-02-6
    纯度: >98.00%

    An ATR inhibitor

  • GC12332 structure
    GC12332NU 7026
    CAS: 154447-35-5
    纯度: >99.50%

    Inhibitor of DNA-dependent protein kinase

  • GC14346 structure
    GC14346KU-0060648
    CAS: 881375-00-4
    纯度: >99.00%

    A dual inhibitor of DNA-PK and PI3K

  • GC10812 structure
    GC10812Compound 401
    CAS: 168425-64-7
    纯度: >99.50%

    A dual inhibitor of mTOR and DNA-PK

  • GC11165 structure
    GC11165PI-103
    CAS: 371935-74-9
    纯度: >98.00%

    PI-103是一种有效的细胞渗透性多靶点抑制剂，主要作用于PI3K和mTOR信号通路。

  • GC11175 structure
    GC11175Daun02
    CAS: 290304-24-4
    纯度: >98.50%

    Daun02 是拓扑异构酶抑制剂柔红霉素的前药。

  • GC11251 structure
    GC11251NU7441 (KU-57788)
    CAS: 503468-95-9
    纯度: >98.50% / >99.50%

    NU7441 (KU-57788)是一种高效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂，IC 50 为13nM。NU7441还抑制磷脂酰肌醇3-激酶（PI3K）和哺乳动物雷帕霉素靶蛋白（mTOR），IC 50 分别为5.0和1.7μM。

  • GC13858 structure
    GC13858Torin 2
    CAS: 1223001-51-1
    纯度: >99.50%

    Selective inhibitor of mTOR

  • GC14371 structure
    GC14371LY3023414
    CAS: 1386874-06-1
    纯度: >98.00%

    LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。

  • GC15485 structure
    GC15485LY 294002
    CAS: 154447-36-6
    纯度: >98.00%

    LY294002是第一个合成的PI3Kα、δ和β抑制剂。

  • GC16379 structure
    GC16379PI-103 Hydrochloride
    CAS: 371935-79-4
    纯度: >98.00%

    PI-103 Hydrochloride是一种有效的细胞渗透性多靶点抑制剂，主要作用于PI3K和mTOR信号通路。

  • GC16582 structure
    GC16582DMNB
    CAS: 20357-25-9

    A photolabile H + -donor used in fluorescence imaging

  • GC16654 structure
    GC16654CC-115
    CAS: 1228013-15-7
    纯度: >98.00%

    A dual inhibitor of mTOR and DNA-PK

  • GC16904 structure
    GC16904PIK-75
    CAS: 372196-77-5
    纯度: >99.50%

    A selective p110α inhibitor

  • GC17199 structure
    GC17199PIK-90
    CAS: 677338-12-4
    纯度: >99.00%

    Potent, cell permeable PI3K inhibitor

  • GC19227 structure
    GC19227LTURM34
    CAS: 1879887-96-3
    纯度: >99.00%

    An inhibitor of DNA-PK

  • GC19328 structure
    GC19328SF2523
    CAS: 1174428-47-7

    A dual inhibitor of PI3K and BRD4

  • GC19390 structure
    GC19390YU238259
    CAS: 1943733-16-1
    纯度: >99.50%

    An inhibitor of homology-dependent DNA repair

  • GC32718 structure
    GC32718M3814 (nedisertib)
    CAS: 1637542-33-6

    M3814 (nedisertib)是一种新型的、具有口服活性的DNA依赖性蛋白激酶（DNA-PK）抑制剂，M3814可抑制DNA-PK的活性来阻断DNA损伤修复通路。

  • GC33325 structure
    GC33325VX-984 (M9831)
    CAS: 1476074-39-1
    纯度: >99.00%

    VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。

  • GC34121 structure
    GC34121CC-115 hydrochloride
    CAS: 1300118-55-1
    纯度: >98.00%

    A dual inhibitor of mTOR and DNA-PK

  • GC34444 structure
    GC34444(R)-Nedisertib
    CAS: 1637542-32-5

    (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。

  • GC34749 structure
    GC34749Rac-Nedisertib
    CAS: 1637542-34-7

    Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。

  • GC50009 structure
    GC50009LY 294002 hydrochloride
    CAS: 934389-88-5
    纯度: >98.00%

    Prototypical PI 3-kinase inhibitor; also inhibits other kinases