DNA Alkylator/Crosslinker
DNA Alkylator/Crosslinker(DNA烷化剂/交联剂)
DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.
DNA Alkylator/Crosslinker 相关产品(72)
- GC11145CyclophosphamideCAS: 50-18-0纯度: >98.00%
环磷酰胺是一种常用的化疗药物，通常与其他类型的化疗药物联合用于治疗乳腺癌、恶性淋巴瘤、多发性骨髓瘤和神经母细胞瘤。
- GC11207CarboplatinCAS: 41575-94-4纯度: >98.00% / >99.00%
卡铂（Carboplatin；NSC 241240）是一种非特异性DNA交联剂，抑制DNA合成和转录，其主要靶点是DNA，而不是特定的蛋白质。
- GC12353Mitomycin CCAS: 50-07-7纯度: >98.00%
Mitomycin C是一种抗生素，从链霉菌（Streptomyces Caespitosus）或淡紫色链霉菌（Streptomyces Lavendulae）中分离出来。
- GC12793RITA (NSC 652287)CAS: 213261-59-7纯度: >99.00%
RITA (NSC 652287)是一种三环噻吩衍生物，可结合p53dN（K d =1.5nM）并阻断p53-HDM-2相互作用，抑制p53泛素化。
- GC13667TemozolomideCAS: 85622-93-1纯度: >98.00% / >98.50%
替莫唑胺是一种口服活性烷化剂，可诱导 DNA 中 O6-甲基鸟嘌呤的形成，其在随后的 DNA 复制周期中与胸腺嘧啶错配，从而激活细胞凋亡途径，替莫唑胺可穿过血脑屏障并适用于恶性神经胶质瘤和转移性黑色素瘤。
- GC14077Cyclophosphamide monohydrateCAS: 6055-19-2纯度: >98.00%
Cyclophosphamide monohydrate是一种合成的DNA烷化剂，是DNA合成的抑制剂。
- GC17131StreptozocinCAS: 18883-66-4纯度: >98.00% / 98.50% / >99.00%
Streptozocin 是一种有效的 DNA 甲基化抗生素，是一种天然存在的亚硝基酰胺，在实验模型中广泛用于产生糖尿病。
- GC32886Miriplatin (SM-11355)CAS: 141977-79-9纯度: >98.00%
Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
- GC32918Treosulfan (NSC 39069)CAS: 299-75-2纯度: >98.00%
Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10339 | VAL-083 | 23261-20-3 | - | |
VAL-083 是一种烷化剂，可在 DNA 上产生 N7 甲基化，具有抗肿瘤活性。 | ||||
| GC10744 | Bendamustine HCl | 3543-75-7 | >98.50% | |
A DNA alkylating agent | ||||
| GC11145 | Cyclophosphamide | 50-18-0 | >98.00% | |
环磷酰胺是一种常用的化疗药物，通常与其他类型的化疗药物联合用于治疗乳腺癌、恶性淋巴瘤、多发性骨髓瘤和神经母细胞瘤。 | ||||
| GC11207 | Carboplatin | 41575-94-4 | >98.00% / >99.00% | |
卡铂（Carboplatin；NSC 241240）是一种非特异性DNA交联剂，抑制DNA合成和转录，其主要靶点是DNA，而不是特定的蛋白质。 | ||||
| GC11793 | Procarbazine HCl | 366-70-1 | - | |
A DNA methylating agent | ||||
| GC11908 | Cisplatin | 15663-27-1 | >98.00% / >99.00% / >99.50% | |
顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体癌症，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤和胃癌等。 | ||||
| GC12353 | Mitomycin C | 50-07-7 | >98.00% | |
Mitomycin C是一种抗生素，从链霉菌（Streptomyces Caespitosus）或淡紫色链霉菌（Streptomyces Lavendulae）中分离出来。 | ||||
| GC12793 | RITA (NSC 652287) | 213261-59-7 | >99.00% | |
RITA (NSC 652287)是一种三环噻吩衍生物，可结合p53dN（K d =1.5nM）并阻断p53-HDM-2相互作用，抑制p53泛素化。 | ||||
| GC12908 | Chlorambucil | 305-03-3 | >98.50% | |
A DNA alkylating agent | ||||
| GC13667 | Temozolomide | 85622-93-1 | >98.00% / >98.50% | |
替莫唑胺是一种口服活性烷化剂，可诱导 DNA 中 O6-甲基鸟嘌呤的形成，其在随后的 DNA 复制周期中与胸腺嘧啶错配，从而激活细胞凋亡途径，替莫唑胺可穿过血脑屏障并适用于恶性神经胶质瘤和转移性黑色素瘤。 | ||||
| GC13671 | Busulfan | 55-98-1 | >98.00% / >97.00% | |
Busulfan是一种烷化剂，可通过烷基化作用修饰DNA，对human serum Paraoxonase 1的IC 50 值为77μM。 | ||||
| GC14077 | Cyclophosphamide monohydrate | 6055-19-2 | >98.00% | |
Cyclophosphamide monohydrate是一种合成的DNA烷化剂，是DNA合成的抑制剂。 | ||||
| GC14564 | Altretamine | 645-05-6 | >99.50% | |
An antineoplastic agent and GPX4 inhibitor | ||||
| GC14762 | Palifosfamide | 31645-39-3 | - | |
An active metabolite of ifosfamide | ||||
| GC15793 | Carmustine | 154-93-8 | >98.00% | |
A DNA alkylating agent | ||||
| GC16003 | Ifosfamide | 3778-73-2 | >98.00% | |
An alkylating agent used to treat cancer | ||||
| GC16158 | Thio-TEPA | 52-24-4 | >98.00% | |
An alkylating agent with anticancer activity | ||||
| GC17131 | Streptozocin | 18883-66-4 | >98.00% / 98.50% / >99.00% | |
Streptozocin 是一种有效的 DNA 甲基化抗生素，是一种天然存在的亚硝基酰胺，在实验模型中广泛用于产生糖尿病。 | ||||
| GC17716 | Oxaliplatin | 61825-94-3 | >98.00% / >99.50% | |
奥沙利铂（Oxaliplatin）是一种用于治疗癌症的细胞毒性化疗药物。 | ||||
| GC17865 | Lomustine | 13010-47-4 | >99.50% | |
A DNA alkylating agent | ||||
| GC19086 | Calicheamicin | 108212-75-5 | >98.00% | |
加利车霉素是一种抗肿瘤抗生素，是一种导致双链 DNA 断裂的细胞毒剂。 | ||||
| GC32187 | Duocarmycin TM | 157922-77-5 | >98.50% | |
DuocarmycinTM是一种非常有效的有抗肿瘤活性的抗生素。 | ||||
| GC32886 | Miriplatin (SM-11355) | 141977-79-9 | >98.00% | |
Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. | ||||
| GC32918 | Treosulfan (NSC 39069) | 299-75-2 | >98.00% | |
Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines. | ||||