GlpBio

DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker(DNA烷化剂/交联剂)

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker 相关产品(72)

  • GC44251 structure
    GC44251MTIC
    CAS: 3413-72-7
    纯度: >99.50%

    A DNA alkylating agent

  • GC46914 structure
    GC46914Bendamustine-d4 (hydrochloride)
    CAS: 2802569-31-7
    纯度: >99.00%

    A neuropeptide with diverse biological activities

  • GC46962 structure
    GC46962Busulfan-d8
    CAS: 116653-28-2
    纯度: >99.00% / >98.00%

    An internal standard for the quantification of busulfan

  • GC47078 structure
    GC47078Chlorambucil-d8
    CAS: 2748247-26-7
    纯度: >99.00%

    苯丁酸氮芥 (CB-1348-d8) 是氘标记的苯丁酸氮芥。苯丁酸氮芥 (CB-1348) 是一种具有口服活性的抗肿瘤剂，是一种属于氮芥类的双功能烷化剂。苯丁酸氮芥可用于淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病的研究。

  • GC49470 structure
    GC494701-Ethyl-1-nitrosourea (hydrate)
    纯度: >95.00%

    A DNA alkylating agent

  • GC52076 structure
    GC52076Temozolomide Acid
    CAS: 113942-30-6
    纯度: >98.00%

    An active metabolite of temozolomide

  • GC52129 structure
    GC521293-Amino-5-hydroxybenzoic Acid
    CAS: 76045-71-1
    纯度: >98.00%

    A biosynthetic precursor to ansamycin antibiotics

  • GC60421 structure
    GC60421(S)-Seco-Duocarmycin SA
    CAS: 152785-82-5
    纯度: >99.00%

    (S)-Seco-DuocarmycinSA是一种DNA烷化剂(DNAalkylator)，可作为抗体药物偶联物的毒素部分(ADCcytotoxin)起作用。

  • GC61182 structure
    GC61182Phosphoramide mustard (cyclohexanamine)
    CAS: 1566-15-0
    纯度: >95.00%

    An alkylating agent and active metabolite of cyclophosphamide

  • GC61188 structure
    GC61188PIP-199
    CAS: 622795-76-0
    纯度: >98.00%

    PIP-199是一种RecQ介导的基因组不稳定蛋白RMI核心复合物/MM2相互作用(RMIcorecomplex/MM2interaction)的选择性抑制剂，其IC50值为36μM。MM2是FANCM上RMI复合物的结合位点。PIP-199可用于耐受肿瘤对DNA交联化疗药物的增敏研究。

  • GC62490 structure
    GC62490PR-104A
    CAS: 680199-06-8

    PR-104A (SN 27858) 是磷酸盐前药 PR-104 的醇代谢物。PR-104A 是一种缺氧选择性的 DNA 交联剂/DNA 损伤剂，也是一种细胞毒素。具有抗肿瘤活性。PR-104A 在缺氧条件下通过 1-电子 NADPH:细胞色素 P450 氧化还原酶代谢。可用于复发/难治性 T 系急性淋巴细胞白血病 (T-ALL) 的研究。

  • GC62501 structure
    GC62501OBI-3424
    CAS: 2097713-68-1
    纯度: >99.00%

    OBI-3424 (TH-3424) 是一种前药，可通过 AKR1C3 (醛基酮还原酶 1C3) 选择性地转化为有效的 DNA 烷基化剂。OBI-3424 可用于肝细胞癌，去势抵抗性前列腺癌和急性淋巴细胞白血病 (ALL) 的研究。

  • GC62691 structure
    GC62691SG3199
    CAS: 1595275-71-0
    纯度: >98.50%

    SG3199 是一种具有细胞毒性的 DNA 小沟链间交联 PDB 二聚体。SG3199 是 ADC 有效载荷 Tesirine (SG3249) 的组成成分。

  • GC63050 structure
    GC63050Lurbinectedin D3

    Lurbinectedin D3 是 Lurbinectedin 的氘代物。Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂，具有高效的抗肿瘤活性; 抑制 RMG1 和 RMG2 的 IC50 值分别为 1.25 和 1.16 nM。

  • GC63154 structure
    GC63154PR-104
    CAS: 851627-62-8
    纯度: >97.00%

    PR-104 是一种选择性缺氧激活的 DNA 交联剂，可用于多种异种肿瘤模型的研究。PR-104 作为氮芥的前体药物，可有效地转化为亲脂性较强的二硝基苯甲酰胺芥菜醇 PR-104A。

  • GC64354 structure
    GC64354Bendamustine
    CAS: 16506-27-7
    纯度: >98.00%

    Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.

  • GC68332 structure
    GC683324-Hydroperoxy Cyclophosphamide-d4
    CAS: 1246816-71-6
    纯度: >95.00%

    4-Hydroperoxy Cyclophosphamide-d4 是 4-Hydroperoxy cyclophosphamide 的氘代物。4-Hydroperoxy cyclophosphamide 是前药 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA，诱导 T 细胞不依赖于死亡受体激活的凋亡，可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 有潜力用于淋巴瘤和自身免疫性疾病的研究。

  • GC69882 structure
    GC69882SG2057
    CAS: 260417-62-7
    纯度: >98.00%

    SG2057 (DRG16) 是一种含有戊二氧基键的 PBD 二聚体，该键选择性地结合 DNA 小沟中的序列，形成 DNA 链间和链内交联加合物。SG2057 是一种高效抗肿瘤剂。

  • GC71560 structure
    GC715602-Iodoacetamide-d4
    CAS: 1219802-64-8
    纯度: >99.00%

    2-Iodoacetamide-d4是氘标记的2-碘乙酰胺。

  • GC74107 structure
    GC74107Tesirine intermediate-2
    CAS: 1430738-34-3
    纯度: >99.00%

    Tesirine intermediate-2是Tesirine的中间体。

  • GC74145 structure
    GC74145Tesirine intermediate-1
    CAS: 1430738-05-8
    纯度: >99.00%

    Tesirine intermediate-1是Tesirine的中间体。

  • GC90549 structure
    GC905495-Aminoimidazole-4-carboxamide (hydrate)
    纯度: >95.00%

    一种合成前体

  • GC90657 structure
    GC90657COMC
    CAS: 106281-45-2
    纯度: >90.00%

    一种抗癌药物。

  • GC91297 structure
    GC91297Cholesterol-Doxorubicin
    纯度: >95.00%

    一种阿霉素的前药形式。