GlpBio

DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker(DNA烷化剂/交联剂)

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker 相关产品(72)

  • GC32946 structure
    GC32946PK11007
    CAS: 38275-34-2
    纯度: >99.00%

    PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.

  • GC34086 structure
    GC34086SJG-136 (NSC-694501)
    CAS: 232931-57-6
    纯度: >98.00%

    SJG-136 (NSC-694501) 是一种 DNA 交联剂，对于 pBR322 DNA 的 XL50 为 45 nM。 SJG-136 (NSC-694501) 具有有效的抗肿瘤活性。

  • GC34305 structure
    GC34305Bendamustine D4 (SDX-105 D4)

    BendamustineD4是Bendamustine的氘代化合物标准品。Bendamustine是一种DNA交联剂(DNAcrosslinker)，能够导致DNA断裂，具有烷基化和抗代谢物的作用。

  • GC34955 structure
    GC34955(+)-CBI-CDPI1
    CAS: 128300-14-1

    (+)-CBI-CDPI1 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI1 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。

  • GC34956 structure
    GC34956(+)-CBI-CDPI2
    CAS: 128300-15-2

    (+)-CBI-CDPI2 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI2 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。

  • GC35310 structure
    GC35310Altretamine hydrochloride
    CAS: 2975-00-0

    An antineoplastic agent and GPX4 inhibitor

  • GC35907 structure
    GC35907Duocarmycin
    CAS: 1116745-06-2

    Duocarmycin 是一种 DNA 小沟烷化剂，是一种抗体药物偶联物 (ADC) 毒素。 Duocarmycin 基于其特有的弯曲吲哚结构和螺环丙基环己二烯酮亲电体发挥抗癌活性。

  • GC35909 structure
    GC35909Duocarmycin GA
    CAS: 1613286-59-1

    Duocarmycin GA 是抗体-药物偶联物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂，靶向 DNA 小沟。Duocarmycin GA 可用于抗多药耐药细胞系。

  • GC35910 structure
    GC35910Duocarmycin MA
    CAS: 1613286-57-9

    Duocarmycin MA 是抗体-药物偶联物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂，靶向 DNA 小沟。Duocarmycin MA 可用于抗多药耐药细胞系。

  • GC35911 structure
    GC35911Duocarmycin MB
    CAS: 1613286-58-0

    Duocarmycin MB 是抗体-药物偶联物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂，靶向 DNA 小沟。Duocarmycin MB 可用于抗多药耐药细胞系。

  • GC36598 structure
    GC36598Methylnitronitrosoguanidine(wetted with ca. 50% Water)
    CAS: 70-25-7
    纯度: >98.00% / >99.50% / >95.00%

    甲基亚硝基胍 (MNNG) 是一种具有口服活性的烷化剂，具有毒性和致突变作用。

  • GC36615 structure
    GC36615Miriplatin hydrate
    CAS: 250159-48-9

    Miriplatin hydrate (SM-11355 hydrate) 为有效的化疗剂，是烷化剂 (alkylator) 的一种。

  • GC37593 structure
    GC37593Satraplatin
    CAS: 129580-63-8
    纯度: >99.50%

    An orally available antineoplastic platinum(IV) complex

  • GC37625 structure
    GC37625Semustine
    CAS: 13909-09-6

    Semustine 是一种 DNA 烷化剂，与 DNA 结合，作为癌症化疗剂。

  • GC37860 structure
    GC37860Uramustine
    CAS: 66-75-1

    Uramustine 是一种可口服的烷化剂 (alkylator)，可用于治疗淋巴肉瘤、慢性淋巴性白血病和血小板增多症。

  • GC38080 structure
    GC38080Duocarmycin Analog
    CAS: 372954-15-9

    Duocarmycin Analog 是 Duocarmycin 的类似物，可用作 DNA 烷化剂 (DNA alkylator) 和 抗体-药物偶联物 (ADC cytotoxin) 的毒素部分。

  • GC38349 structure
    GC38349Seco-Duocarmycin SA
    CAS: 144667-38-9

    Seco-Duocarmycin SA 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体-药物偶联物 (ADC) 的毒素部分。

  • GC38354 structure
    GC38354Seco-Duocarmycin TM
    CAS: 236102-87-7

    Seco-Duocarmycin TM 是 Duocarmycins 家族的一种 DNA 烷化剂，可抑制 DNA 合成。Seco-Duocarmycin TM 是一种细胞毒性剂，用作抗体-药物偶联物中的细胞毒性成分。

  • GC39498 structure
    GC39498N-Nitroso-N-methylurea
    CAS: 684-93-5
    纯度: >98.00% / >99.50%

    N-Nitroso-N-methylurea（NMU; MNU; NMH）是一种有效的致癌剂，诱变剂和致畸剂。

  • GC41340 structure
    GC41340Illudin M
    CAS: 1146-04-9
    纯度: >95.00%

    A DNA alkylating agent

  • GC41384 structure
    GC41384K-TMZ
    CAS: 2269482-26-8
    纯度: >95.00%

    A DNA alkylating agent

  • GC42401 structure
    GC424014-hydroperoxy Cyclophosphamide
    CAS: 39800-16-3
    纯度: >98.00% / >95.00%

    4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。

  • GC43209 structure
    GC43209CB-1954
    CAS: 21919-05-1
    纯度: >99.50%

    An antitumor prodrug

  • GC44243 structure
    GC44243Monohydroxy Melphalan (hydrochloride)
    CAS: 2707535-88-2
    纯度: >95.00%

    A DNA alkylating agent