3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin , as well as the antitumor antibiotic mitomycin C .1,2
1.Kim, C.-G., Kirschning, A., Bergon, P., et al.Biosynthesis of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibioticsJ. Am. Chem. Soc.118(32)7486-7491(1996) 2.Mao, Y., Varoglu, M., and Sherman, D.H.Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564Chem. Biol.6(4)251-263(1999)