Checkpoint Kinase (Chk)
Checkpoint Kinase (Chk)(细胞周期检查点激酶)
Checkpoint Kinases (Chk) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, embryo development, cellular responses to HIV infection and somatic cell viability. Chk2 is a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor.
Checkpoint Kinase (Chk) 相关产品(32)
- GC16374MK-8776(SCH-900776)CAS: 891494-63-6纯度: >99.50%
MK-8776(SCH-900776) 是一种新型、选择性更高的Chk1抑制剂，旨在通过废除细胞周期阻滞来增强DNA损伤剂和抗代谢物的细胞毒性。
- GC34127GDC-0575 dihydrochloride (ARRY-575 dihydrochloride)CAS: 1657014-42-0纯度: >99.50%
A Chk1 inhibitor
- GC36966Prexasertib dihydrochlorideCAS: 1234015-54-3纯度: >99.00%
Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay.
- GC36967Prexasertib Mesylate HydrateCAS: 1234015-57-6
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) 是一种有效、选择性、 ATP 竞争性的 CHK1 和 CHK2 抑制剂，对 CHK1 的 Ki 值为 0.9 nM，IC50 值 <1 nM，对 CHK2 的 IC50 值为 8 nM。Prexasertib Mesylate Hydrate 抑制 HT-29 细胞 CHK1 (S296) 和 CHK2 (S516) 的自身磷酸化。Prexasertib Mesylate Hydrate 具有高效抗肿瘤活性，在 HeLa 细胞中，消除 G2/M 检查点，EC50 值为 9 nM。
- GC50085CCT 241533 dihydrochlorideCAS: 1962925-28-5纯度: >99.00%
CCT 241533 dihydrochloride 是一种有效的选择性 ATP 竞争性 CHK2 抑制剂，IC50 为 3 nM，Ki 为 1.16 nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10546 | AZD7762 | 860352-01-8 | >99.50% | |
A selective checkpoint kinase inhibitor | ||||
| GC11022 | SB 218078 | 135897-06-2 | >98.00% | |
A potent Chk1 inhibitor | ||||
| GC11648 | BML-277 | 516480-79-8 | >98.00% | |
A selective DNA damage control kinase inhibitor | ||||
| GC14234 | PF-477736 | 952021-60-2 | >99.00% | |
A selective inhibitor of checkpoint kinase 1 | ||||
| GC14772 | CCT244747 | 1404095-34-6 | >99.00% | |
A potent Chk1 inhibitor | ||||
| GC15663 | LY2606368 | 1234015-52-1 | >98.00% | |
LY2606368 是一种 ATP 竞争性 CHK1 抑制剂，目前处于临床阶段，Ki 为 0.9 nM，IC50 <1 nM。 | ||||
| GC15739 | CHIR-124 | 405168-58-3 | >98.00% | |
A selective Chk1 inhibitor | ||||
| GC15741 | LY2603618 | 911222-45-2 | >98.00% | |
A Chk1 inhibitor | ||||
| GC16374 | MK-8776(SCH-900776) | 891494-63-6 | >99.50% | |
MK-8776(SCH-900776) 是一种新型、选择性更高的Chk1抑制剂，旨在通过废除细胞周期阻滞来增强DNA损伤剂和抗代谢物的细胞毒性。 | ||||
| GC17105 | CCT241533 hydrochloride | 1431697-96-9 | >99.00% | |
A selective Chk2 inhibitor | ||||
| GC18053 | CCT241533 | 1262849-73-9 | - | |
A selective Chk2 inhibitor | ||||
| GC18396 | PD 407824 | 622864-54-4 | >98.00% | |
An inhibitor of Chk1 and WEE1 | ||||
| GC19093 | CCT245737 | 1489389-18-5 | >99.00% | |
A potent Chk1 inhibitor | ||||
| GC30106 | CHK1 inhibitor | 2097938-64-0 | - | |
CHK1inhibitor是CHK1的抑制剂。 | ||||
| GC32885 | GDC-0575 (ARRY-575, RG7741) | 1196541-47-5 | >99.50% | |
A Chk1 inhibitor | ||||
| GC33289 | CHK1-IN-2 | 912367-45-4 | - | |
CHK1-IN-2是细胞周期检测点激酶(CHK1)的抑制剂，其IC50为6nM。 | ||||
| GC33392 | CHK-IN-1 | 1278405-51-8 | - | |
CHK-IN-1是一种CHK1和CHK2的抑制剂，具有抗增殖作用。 | ||||
| GC34127 | GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) | 1657014-42-0 | >99.50% | |
A Chk1 inhibitor | ||||
| GC35679 | CHK1-IN-3 | 2097252-39-4 | - | |
CHK1-IN-3 是一种检测点激酶 (CHK1) 抑制剂，IC50 值为 0.4 nM。 | ||||
| GC36966 | Prexasertib dihydrochloride | 1234015-54-3 | >99.00% | |
Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. | ||||
| GC36967 | Prexasertib Mesylate Hydrate | 1234015-57-6 | - | |
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) 是一种有效、选择性、 ATP 竞争性的 CHK1 和 CHK2 抑制剂，对 CHK1 的 Ki 值为 0.9 nM，IC50 值 <1 nM，对 CHK2 的 IC50 值为 8 nM。Prexasertib Mesylate Hydrate 抑制 HT-29 细胞 CHK1 (S296) 和 CHK2 (S516) 的自身磷酸化。Prexasertib Mesylate Hydrate 具有高效抗肿瘤活性，在 HeLa 细胞中，消除 G2/M 检查点，EC50 值为 9 nM。 | ||||
| GC39284 | ANI-7 | 931417-26-4 | >99.00% | |
ANI-7 是一种 AhR 途径的激活剂。ANI-7 抑制多种癌细胞的生长，并有选择地抑制 MCF-7 乳腺癌细胞的生长，GI50 为 0.56 μM。ANI-7 通过激活 AhR 途径诱导 CYP1 代谢单加氧酶，并在敏感的乳腺癌细胞系中诱导 DNA 损伤，检查点激酶 (Chk2) 激活，S 期细胞周期停滞和细胞死亡。 | ||||
| GC49430 | Wee1 Inhibitor | 622855-37-2 | >95.00% | |
An inhibitor of Wee1 | ||||
| GC50085 | CCT 241533 dihydrochloride | 1962925-28-5 | >99.00% | |
CCT 241533 dihydrochloride 是一种有效的选择性 ATP 竞争性 CHK2 抑制剂，IC50 为 3 nM，Ki 为 1.16 nM。 | ||||