306-O12B-3 is an ionizable cationic lipidoid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of antisense oligonucleotides (ASOs). LNPs containing 306-O12B-3 localize to the liver after intravenous administration in mice. LNPs containing 306-O12B-3 in combination with other lipids encapsulating ASOs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) decrease hepatic PCSK9 expression in mice. Intravenous administration of LNPs containing 306-O12B-3 and the cationic lipidoid NT1-O14B encapsulating ASOs against tau decreases tau expression and levels in mouse brain.2
1.Yang, L., Ma, F., Liu, F., et al.Efficient delivery of antisense oligonucleotides using bioreducible lipid nanoparticles in vitro and in vivoMol. Ther. Nucleic Acids191357-1367(2020) 2.Ma, F., Yang, L., Sun, Z., et al.Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injectionSci. Adv.6(30)eabb4429(2020)