Minosaminomycin is an antibiotic that has been found in Streptomyces.1 It is active against M. smegmatis and M. phlei (MICs = 1.56 and 6.25 µg/ml, respectively). Minosaminomycin (1 µM) inhibits the binding of formyl-Met-tRNA (fMet-tRNA) to ribosomes in the presence of the AUG trinucleotide by 96% in a cell-free assay and inhibits Mycobacterium protein synthesis when used at a concentration of 100 µM.2
1.Hamada, M., Kondo, S., Yokoyama, T., et al.Letter: Minosaminomycin, a new antibiotic containing myo-inosamineJ. Antibiot. (Tokyo)27(1)81-83(1974) 2.Suzukake, K., and Hori, M.Biochemical study of minosaminomycin in relation to the kasugamycin group antibioticsJ. Antibiot. (Tokyo)30(2)132-140(1977)