MAPK Signaling
MAPK Signaling(MAPK信号通路)
MAPK Signaling 相关产品(575)
- GC20007Ginsenoside CKCAS: 39262-14-1纯度: >98.00%
Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。
- GC25289CompK
CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells.
- GC25420Fipexide hydrochlorideCAS: 34161-23-4
Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
- GC25521IMM-H007CAS: 1221412-23-2
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
- GC25982Tanzisertib(CC-930)CAS: 899805-25-5(freebase)纯度: >98.00%
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
- GC30158p38-α MAPK-IN-1CAS: 443913-15-3纯度: >99.50%
p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
- GC30162trans-ZeatinCAS: 1637-39-4纯度: >98.50%
trans-Zeatin是一种天然的细胞分裂素（cytokinin），属于植物生长调节剂，在植物细胞生长、分化和分裂中起核心作用。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC19091 | CCT196969 | 1163719-56-9 | >99.50% | |
A multi-kinase inhibitor | ||||
| GC19131 | Tomivosertib | 1849590-01-7 | >98.00% | |
A potent inhibitor of MNK1 and MNK2 | ||||
| GC19173 | GNE-3511 | 1496581-76-0 | >99.50% | |
A selective and highly potent inhibitor of DLK | ||||
| GC19228 | LXH254 | 1800398-38-2 | >99.50% | |
A pan-RAF inhibitor | ||||
| GC19235 | LY3214996 | 1951483-29-6 | >99.50% | |
An ERK1/2 inhibitor | ||||
| GC19260 | NCB-0846 | 1792999-26-8 | >98.00% | |
A TNIK inhibitor | ||||
| GC19304 | R1487 Hydrochloride | 449808-64-4 | >98.50% | |
An inhibitor of p38α MAPK | ||||
| GC19307 | RAF709 | 1628838-42-5 | >98.50% | |
A potent inhibitor of B-RAF and C-RAF | ||||
| GC19325 | SD 0006 | 271576-80-8 | >98.50% | |
An inhibitor of p38α MAPK | ||||
| GC19366 | UM-164 | 903564-48-7 | >98.50% | |
An inhibitor of Src and p38 MAPK kinases | ||||
| GC19396 | H 89 | 127243-85-0 | >98.00% | |
A PKA inhibitor | ||||
| GC19479 | AZ304 | 942507-42-8 | >99.00% | |
AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制野生型 BRAF、V600E 突变型 BRAF 和野生型 CRAF，IC50 分别为 79 nM、38 nM 和 68 nM。 AZ304 对其他激酶也有显着影响，例如 p38 (IC50, 6 nM)、CSF1R (IC50, 35 nM)。抗肿瘤活性。 | ||||
| GC19507 | LUT-014 | 2274819-46-2 | - | |
LUT-014 是一种 B-Raf 抑制剂，IC50 为 11.7 nM，用于减少与 EGFR 抑制剂治疗相关的剂量限制性痤疮样病变。 | ||||
| GC19843 | Nimbolide | 25990-37-8 | >98.00% | |
An anticancer phytochemical | ||||
| GC20007 | Ginsenoside CK | 39262-14-1 | >98.00% | |
Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。 | ||||
| GC25289 | CompK | - | - | |
CompK (compound K), a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor, significantly improves human T-cell functions, with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8+ T cells. | ||||
| GC25420 | Fipexide hydrochloride | 34161-23-4 | - | |
Fipexide (hydrochloride) is a psychoactive drug of the piperazine class. | ||||
| GC25521 | IMM-H007 | 1221412-23-2 | - | |
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux. | ||||
| GC25982 | Tanzisertib(CC-930) | 899805-25-5(freebase) | >98.00% | |
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively. | ||||
| GC30057 | D-JNKI-1 (AM-111) | 1445179-97-4 | - | |
D-JNKI-1 (AM-111) (AM-111) 是一种高效且可渗透细胞的 JNK 肽抑制剂。 | ||||
| GC30158 | p38-α MAPK-IN-1 | 443913-15-3 | >99.50% | |
p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. | ||||
| GC30162 | trans-Zeatin | 1637-39-4 | >98.50% | |
trans-Zeatin是一种天然的细胞分裂素（cytokinin），属于植物生长调节剂，在植物细胞生长、分化和分裂中起核心作用。 | ||||
| GC30545 | Malantide | 86555-35-3 | >98.50% | |
Malantide是一种十二肽，能够被PKA磷酸化，并且能够增强PKA的活性。 | ||||
| GC30609 | p38 MAPK-IN-2 | 635725-16-5 | - | |
p38MAPK-IN-2是一种p38kinase的抑制剂。 | ||||