GlpBio

MAPK Signaling

MAPK Signaling(MAPK信号通路)

研究方向

MAPK Signaling 相关产品(575)

  • GC30646 structure
    GC30646Skatole(3-Methylindole)
    CAS: 83-34-1
    纯度: >99.50%

    Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

  • GC30676 structure
    GC30676MAPK13-IN-1
    CAS: 229002-10-2
    纯度: >98.00%

    MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。

  • GC30770 structure
    GC30770LM22B-10
    CAS: 342777-54-2
    纯度: >98.00%

    An activator of TrkB and TrkC

  • GC30857 structure
    GC30857Warangalone (Scandenolone)
    CAS: 4449-55-2
    纯度: >98.00%

    Warangalone (Scandenolone) 是一种抗疟疾化合物，可抑制寄生虫 3D7（氯喹敏感）和 K1（氯喹抗性）两种菌株的生长，IC50 分别为 4.8 μg/mL 和 3.7 μg/mL。

  • GC30864 structure
    GC30864SR-3306
    CAS: 1128096-91-2
    纯度: >99.00%

    SR-3306是一种有效的可渗透脑的选择性JNK抑制剂。

  • GC30913 structure
    GC30913DLK-IN-1
    CAS: 1620574-24-4
    纯度: >99.00%

    DLK-IN-1是双亮氨酸拉链激酶(DLK,MAP3K12)的选择性抑制剂，其Ki值为3nM。DLK-IN-1保持着良好的中枢神经系统穿透能力，并且在脑内剂量过量后依旧耐受性良好，在阿尔兹海默症动物模型中有良好的活性。

  • GC31058 structure
    GC31058FR 167653 free base
    CAS: 158876-65-4

    FR-167653是一种选择性的p38MAPK抑制剂。

  • GC31525 structure
    GC31525CREBtide
    CAS: 149155-45-3
    纯度: >98.50%

    CREBtide 是一种合成的 13 个氨基酸肽，已被报道为 PKA 底物。

  • GC31647 structure
    GC31647Tomatidine
    CAS: 77-59-8
    纯度: >99.50% / >98.00%

    A steroidal alkaloid with diverse biological activities

  • GC31667 structure
    GC31667AX-15836
    CAS: 2035509-96-5
    纯度: >98.00%

    AX-15836是有效，选择性的ERK5抑制剂，IC50值为8nM。

  • GC31675 structure
    GC31675PF-06260933
    CAS: 1811510-56-1
    纯度: >98.00%

    A MAP4K4 inhibitor

  • GC31697 structure
    GC31697Dilmapimod (SB-681323)
    CAS: 444606-18-2
    纯度: >99.50%

    Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

  • GC31735 structure
    GC31735Magnolin
    CAS: 31008-18-1
    纯度: >98.50%

    A lignan with anti-inflammatory and anticancer activities

  • GC31924 structure
    GC31924AZD7624
    CAS: 1095004-78-6
    纯度: >98.00%

    AZD7624是一种可吸入的p38抑制剂，具有高效的抗炎活性。

  • GC31988 structure
    GC31988p38α inhibitor 1
    CAS: 1034189-82-6
    纯度: >98.50%

    p38αinhibitor1是p38α的抑制剂，来自专利WO2008076265A1。

  • GC32209 structure
    GC32209ITX5061
    CAS: 1252679-52-9
    纯度: >98.00%

    ITX5061是一个II型p38MAPK抑制剂，也是清道夫受体B1(SR-B1)的拮抗剂。

  • GC32254 structure
    GC32254Deltonin
    CAS: 55659-75-1
    纯度: >99.50%

    Deltonin是从盾叶薯蓣中得到的甾体皂苷，能够抑制ERK1/2和AKT的活化，具有抗肿瘤的活性。

  • GC32411 structure
    GC32411FR 167653 (FR 167653 sulfate)
    CAS: 158876-66-5

    FR 167653 (FR 167653硫酸盐) (FR 167653 (FR 167653硫酸盐))，一种具有口服活性和选择性的p38 MAPK抑制剂，是TNF-α的强效抑制剂；和 IL-1β；通过特异性抑制 p38 MAPK 活性产生。

  • GC32686 structure
    GC32686PLX8394
    CAS: 1393466-87-9

    PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.

  • GC32687 structure
    GC32687Takinib
    CAS: 1111556-37-6
    纯度: >98.00%

    A TAK1 inhibitor

  • GC32692 structure
    GC32692APTO-253 (LOR-253)
    CAS: 916151-99-0
    纯度: >98.00%

    APTO-253 是一种新型小分子，通过诱导 Kruppel 样因子 4 (KLF4) 主转录因子基因表达，从而抑制细胞周期并导致程序性细胞死亡，发挥强大的抗肿瘤活性。

  • GC32789 structure
    GC32789Mogrol
    CAS: 88930-15-8
    纯度: >99.00%

    Mogrol是罗汉果甜甙的生物代谢物，能够抑制ERK1/2和STAT3的信号通路，同时能降低CREB的活性，活化AMPK。

  • GC32796 structure
    GC32796ERK5-IN-1
    CAS: 1234479-76-5
    纯度: >99.50%

    An ERK5 inhibitor

  • GC32797 structure
    GC32797AD80
    CAS: 1384071-99-1
    纯度: >99.50%

    AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.