PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

Cat.No. 产品名称 Information

GC13648 CC-223

CC-223; ATG-008

A potent, selective inhibitor of mTOR

GC65944 CC214-2 CC214-2 是一种有效的 mTORC1/mTORC2 双重抑制剂。结核分枝杆菌调节哺乳动物雷帕霉素靶蛋白 (mTOR) 信号传导以阻止自噬。CC214-2 有可能缩短结核病的持续时间。

GC15864 CCT128930 An inhibitor of Akt2

GC63539 CCT128930 hydrochloride An inhibitor of Akt2

GC73183 CDK8-IN-12 CDK8-IN-12是一种有效的口服CDK8抑制剂，Ki值为14 nM。

GC35651 Cenisertib

AS-703569; R-763

Cenisertib (AS-703569) 是一种多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。

GC10070 CGS 15943

CGS 15943A

A potent adenosine receptor antagonist

GC11868 CH5132799

[5-[7-甲磺酰基-2-(吗啉-4-基)-6,7-二氢-5H-吡咯并[2,3-D]嘧啶-4-基]嘧啶-2-基]胺,CH5132799

An inhibitor of class I PI3K isoforms

GC15642 CHIR 99021 trihydrochloride

CHIR-99021 trihydrochloride; CT99021 trihydrochloride

A selective GSK3 inhibitor

GC12176 CHIR-98014 CHIR-98014是一种具细胞渗透性的GSK-3α和GSK-3β的强效抑制剂，IC₅₀值分别为0.65nM和0.58nM。

GC16702 CHIR-99021 (CT99021)

CHIR99021, CHIR-99021, CHIR 99021, CT99021,GSK-3 Inhibitor XVI

CHIR-99021是最常用的GSK-3β抑制剂，被认为是标准的小分子Wnt激动剂。

GC17153 CHIR-99021 (CT99021) HCl

CHIR-99021 monohydrochloride; CT99021 monohydrochloride

A selective GSK3 inhibitor

GC49392 CHIR98024

CT 98024

A GSK3 inhibitor

GC31383 Chitosan oligosaccharide COS

壳聚糖低聚乳酸酯,COS

Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).

GC65969 CHMFL-PI3KD-317 CHMFL-PI3KD-317 是一种高效、选择性、可口服的 PI3Kδ 抑制剂，IC50 值为 6 nM，对其选择性是对其他 PIKK 家族的 10-1500 倍，例如 PI3Kα (IC50，62.6 nM)，PI3Kβ (IC50，284 nM)，PI3Kγ (IC50，202.7 nM)，PIK3C2A (IC50，>10000 nM)，PIK3C2B (IC50，882.3 nM)，VPS34 (IC50，1801.7 nM)，PI4KIIIA (IC50，574.1 nM) 和 PI4KIIIB (IC50，300.2 nM)。在 Raji 细胞中，CHMFL-PI3KD-317 抑制 PI3Kδ 介导的 Akt T308 磷酸化，EC50 值为 4.3 nM。CHMFL-PI3KD-317 对癌细胞具有抗增殖作用。

GC12532 CHPG

Chlorohydroxyphenylglycine, CHPG

A potent and selective mGluR5 agonist

GC17963 CHPG Sodium salt CHPG 钠盐是一种选择性 mGluR5 激动剂，可通过 BV2 小胶质细胞中的 TSG-6/NF-κB 通路减弱 SO2 诱导的氧化应激和炎症。

GN10222 Cimigenol-3-O-α-L-arabinoside

千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Cimicifugoside M

Cimigenol-3-O-α-L-arabinoside 是总状升麻的活性成分，可激活 AMPK，具有潜在的抗糖尿病活性。

GC14693 CMK

1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮

CMK 是一种 RSK2 激酶抑制剂，与 FMK 相比，具有相似的效力，但化学稳定性较低。

GC19109 CNX-1351 A PI3Kα inhibitor

GC62548 COH-SR4 COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.

GC43302 Compound 23

mTOR Inhibitor WYE-23

An inhibitor of mTOR

GC43303 Compound 28 An inhibitor of mTOR

GC10812 Compound 401 A dual inhibitor of mTOR and DNA-PK

GC46123 Comprehensive Kinase Screening Library For screening of a variety of kinase inhibitors

GC13176 CP21R7

GSK-3Β抑制剂(CP21R7),CP21

A GSK3β inhibitor used to differentiate stem cells

GC35747 Crebanine

克班宁

An aporphine alkaloid with diverse biological activities

GC17690 Cromolyn sodium

色甘酸钠; Disodium Cromoglycate; FPL-670

A mast cell stabilizer

GC30582 Crosstide A peptide substrate for Akt

GC52387 Crosstide (trifluoroacetate salt)

Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH, GRPRTSSFAEG-OH

A peptide substrate for Akt

GC12115 CUDC-907

CUDC-907

CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。

GC13037 CX-4945 (Silmitasertib)

CX 4945;CX4945

A potent, orally bioavailable CK2 inhibitor

GC11325 CX-4945 sodium salt

CX-4945 sodium salt

A potent, orally bioavailable CK2 inhibitor

GC38419 Cyclovirobuxine D

黄杨碱

An alkaloid with diverse biological activities

GC68413 CYH33 CYH33 是一种具有口服活性的，高选择性 PI3Kα 抑制剂，对 α/β/δ/γ 亚型的 IC50 分别为 5.9 nM/598 nM/78.7 nM/225 nM。CYH33 抑制 Akt 和 ERK 的磷酸化，并显着诱导乳腺癌和非小细胞肺癌 (NSCLC) 细胞 G1 期阻滞。CYH33 具有有效的抗实体瘤的活性。

GC63391 CYH33 methanesulfonate CYH33 methanesulfonate 是一种具有口服活性的，高选择性 PI3Kα 抑制剂，对 α/β/δ/γ 亚型的 IC50 分别为 5.9 nM/598 nM/78.7 nM/225 nM。CYH33 methanesulfonate 抑制 Akt 和 ERK 的磷酸化，并显着诱导乳腺癌和非小细胞肺癌 (NSCLC) 细胞 G1 期阻滞。CYH33 methanesulfonate 具有有效的抗实体瘤的活性。

GC43354 Cysmethynil

Icmt Inhibitor

An inhibitor of protein prenylation

GC19114 CZ415 An mTOR inhibitor

GC14798 CZC24832

5-(2-氨基-8-氟[1,2,4]三唑并[1,5-A]吡啶-6-基)-N-(叔丁基)-3-吡啶磺酰胺,CZC 24832;CZC-24832

A PI3Kγ inhibitor

GC43514 D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt)

Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5 (sodium salt)

An anticancer inositol phosphate

GC43515 D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt)

Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5

An anticancer inositol phosphate

GC18583 D-α-Hydroxyglutaric Acid

R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K_i = 10.87mM）。

GC30056 Danthron (Dantron)

1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.

GC11175 Daun02

(8S,10S)-8-乙酰基-7,8,9,10-四氢-6,8,11-三羟基-1-甲氧基-10-[[2,3,6-三脱氧-3-[[[[4-(BETA-D-吡喃半乳糖基氧基)-3-硝基苯基]甲氧基]羰基]氨基]-ALPHA-L-来苏-己糖吡喃糖苷]氧基]-5,12-并四苯醌,Daun 02; Daun-02

Daun02 是拓扑异构酶抑制剂柔红霉素的前药。