PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)
PI3K/Akt/mTOR Signaling 相关产品(648)
- GC12338WortmanninCAS: 19545-26-7纯度: >99.50% / >98.00% / >99.00%
渥曼青霉素是一种高效的 PI3 激酶特异性直接抑制剂，最初源自真菌 (1,2)。
- GC12415RigosertibCAS: 592542-59-1纯度: >98.50%
Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3 激酶/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。
- GC12573Temsirolimus (CCI-779)CAS: 162635-04-3纯度: >99.50%
Temsirolimus (CCI-779)是雷帕霉素的酯类衍生物，可抑制mTOR激酶活性，IC 50 值为1.76 ± 0.15μM。
- GC12661Indirubin-3'-oximeCAS: 160807-49-8纯度: >99.00%
Inhibitor of GSK3β and cyclin-dependent kinases
- GC12866PDK1 inhibitorCAS: 1001409-50-2纯度: >99.50%
PDK1 inhibitor (PDK1 inhibitor) 是一种磷酸肌醇依赖性激酶-1 (PDK1) 抑制剂。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11910 | AS-041164 | 6318-41-8 | >99.00% | |
Selective inhibitor of PI3Kγ | ||||
| GC11931 | BKM120 | 944396-07-0 | >99.50% | |
An inhibitor of class I PI3K isoforms | ||||
| GC11985 | SC 66 | 871361-88-5 | >99.50% | |
A dual inhibitor of Akt | ||||
| GC12021 | GDC-0349 | 1207360-89-1 | >98.00% | |
A potent inhibitor of mTOR | ||||
| GC12089 | LY2584702 | 1082949-67-4 | >98.00% | |
A p70S6K inhibitor | ||||
| GC12094 | PHT-427 | 1191951-57-1 | >99.50% | |
An inhibitor of Akt and PDPK1 | ||||
| GC12162 | ZLN024 hydrochloride | 1883548-91-1 | >98.50% | |
An allosteric activator of AMPK | ||||
| GC12297 | AT7867 | 857531-00-1 | >98.00% | |
A potent and orally bioavailable pan-Akt inhibitor | ||||
| GC12324 | RSVA 405 | 140405-36-3 | >99.50% | |
RSVA 405 是一种有效的口服活性 AMPK 激活剂，EC50 为 1 μM。 | ||||
| GC12338 | Wortmannin | 19545-26-7 | >99.50% / >98.00% / >99.00% | |
渥曼青霉素是一种高效的 PI3 激酶特异性直接抑制剂，最初源自真菌 (1,2)。 | ||||
| GC12364 | SAMS Peptide | 125911-68-4 | - | |
A specific substrate for AMPK | ||||
| GC12375 | PF-4989216 | 1276553-09-3 | >99.50% | |
An orally bioavailable PI3K inhibitor | ||||
| GC12415 | Rigosertib | 592542-59-1 | >98.50% | |
Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3 激酶/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。 | ||||
| GC12416 | INK1117 | 1268454-23-4 | >99.00% | |
A selective inhibitor of PI3Kα | ||||
| GC12474 | AS-605240 | 648450-29-7 | >99.00% | |
A potent inhibitor of PI3-kinase γ | ||||
| GC12502 | A-443654 | 552325-16-3 | >99.00% | |
A pan Akt inhibitor | ||||
| GC12532 | CHPG | 170846-74-9 | >98.00% | |
A potent and selective mGluR5 agonist | ||||
| GC12573 | Temsirolimus (CCI-779) | 162635-04-3 | >99.50% | |
Temsirolimus (CCI-779)是雷帕霉素的酯类衍生物，可抑制mTOR激酶活性，IC 50 值为1.76 ± 0.15μM。 | ||||
| GC12576 | AZD8186 | 1627494-13-6 | >99.50% | |
A PI3Kβ/δ inhibitor | ||||
| GC12661 | Indirubin-3'-oxime | 160807-49-8 | >99.00% | |
Inhibitor of GSK3β and cyclin-dependent kinases | ||||
| GC12709 | XL147 | 956958-53-5 | >99.50% | |
An analog of XL147 | ||||
| GC12866 | PDK1 inhibitor | 1001409-50-2 | >99.50% | |
PDK1 inhibitor (PDK1 inhibitor) 是一种磷酸肌醇依赖性激酶-1 (PDK1) 抑制剂。 | ||||
| GC12889 | PX 866 | 502632-66-8 | >99.00% | |
An inhibitor of PI3K | ||||
| GC13006 | 10-DEBC hydrochloride | 925681-41-0 | - | |
A selective inhibitor of Akt | ||||