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Home >> Signaling Pathways >> MAPK Signaling

MAPK Signaling(MAPK信号通路)

Products for  MAPK Signaling

  1. Cat.No. 产品名称 Information
  2. GC16039 LJH685

    2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚

     An inhibitor of RSKs
  3. GC16601 LJI308 An inhibitor of RSKs
  4. GC11157 LL-Z 1640-4

    Antibiotic LLZ1640-4,(5Z)-Zeaenol,Curvularia Sp.

     A negative control for MAPK signaling
  5. GC30770 LM22B-10 An activator of TrkB and TrkC
  6. GC34650 Longdaysin

    Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.
  7. GC13717 Losmapimod

    洛批莫德; GSK-AHAB; GW856553X; SB856553

     A dual p38α and p38β MAPK inhibitor
  8. GN10267 Loureirin B

    龙血素 B

     A flavonoid with diverse biological activities
  9. GC73607 LUNA18 LUNA18是一种口服的环肽KRAS和ERK抑制剂。
  10. GC19507 LUT-014 LUT-014 是一种 B-Raf 抑制剂，IC50 为 11.7 nM，用于减少与 EGFR 抑制剂治疗相关的剂量限制性痤疮样病变。
  11. GC19228 LXH254 A pan-RAF inhibitor
  12. GC36505 LY-2584702 hydrochloride

    LY-2584702盐酸盐

     LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
  13. GC16835 LY2228820

    5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate

     A potent inhibitor of p38α MAP kinase
  14. GC12089 LY2584702 A p70S6K inhibitor
  15. GC44095 LY2584702 (tosylate)

    LYS6K2

     LY2584702 (tosylate)是一种强效、高选择性的p70 S6激酶的ATP竞争性抑制剂，属于磷脂酰肌醇-3-激酶信号通路的下游组分，IC50值为0.004μM。
  16. GC13980 LY3009120

    DP-4978

     LY3009120 是一种泛 RAF 和 RAF 二聚体抑制剂，可抑制所有 RAF 亚型并占据 RAF 二聚体中的两个原聚体。
  17. GC19235 LY3214996

    LY3214996

     An ERK1/2 inhibitor
  18. GC18241 Lysophosphatidylcholines

    L-溶血卵磷脂,Lyso-Lecithins (egg)

     Lysophosphatidylcholines是一类重要的磷脂分子，是磷脂酶A2水解磷脂酰胆碱的产物。
  19. GC39715 M2698

    MSC2363318A

     A dual inhibitor of p70S6K and Akt1
  20. GC31735 Magnolin

    木兰苷

     A lignan with anti-inflammatory and anticancer activities
  21. GC30545 Malantide Malantide是一种十二肽，能够被PKA磷酸化，并且能够增强PKA的活性。
  22. GC63059 MAP4K4-IN-3 MAP4K4-IN-3 is a potent and selective Mitogen-activated protein kinase 4 (MAP4K4) inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
  23. GC64904 MAP855 MAP855 是一种高效、具有选择性且口服有效的 ATP 竞争性 MEK1/2 激酶抑制剂 (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM)。MAP855 对野生型和突变型 MEK1/2 具有同等的抑制作用。
  24. GC73590 MAPK-IN-2 MAPK-IN-2（化合物3h）是一种具有抗肿瘤活性的强效MAPK抑制剂。
  25. GC30676 MAPK13-IN-1 MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。
  26. GC61032 MCP110 MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.
  27. GC11277 MEK inhibitor

    (3Z)-3-[[[3-[(二甲基氨基)甲基]苯基]氨基]苯基亚甲基]-2,3-二氢-N-甲基-2-氧代-1H-吲哚-6-甲酰胺,1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-

     MEK 抑制剂是一种有效的 MEK 抑制剂，具有抗肿瘤效力。
  28. GC33388 MEK-IN-1 MEK-IN-1是来自专利WO2008076415A1的MEK抑制剂。
  29. GC73446 MEK-IN-6 MEK-IN-6（实施例69）是MEK抑制剂。
  30. GC12843 MEK162 (ARRY-162, ARRY-438162)

    贝美替尼,MEK162; ARRY-162; ARRY-438162

     A MEK1/2 inhibitor
  31. GC33771 Metadoxine

    美他多辛

     Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.
  32. GC49241 Methyl Diethyldithiocarbamate

    S-甲基N,N二乙基二硫代氨基甲酸

     An active metabolite of disulfiram
  33. GC44181 Methylcarbamyl PAF C-8 C-8 analog of Methylcarbamyl PAF C-16
  34. GC36596 Methylnissolin

    黄芪紫檀烷苷; Astrapterocarpan

     A flavonoid with antiproliferative activity
  35. GC16007 Methylthiouracil

    甲硫氧嘧啶; MTU

     甲基硫氧嘧啶是一种抗甲状腺药物。
  36. GC40231 Milrinone-d3 An internal standard for the quantification of milrinone
  37. GC44211 MK2 Inhibitor III A potent, cell-permeable inhibitor of MK2
  38. GC16723 MK2 Inhibitor IV

    MK 25

     A highly selective MAPKAPK2 (MK2) inhibitor
  39. GC33142 MK2-IN-1 (MK2 Inhibitor) MK2-IN-1 (MK2 Inhibitor) 是一种有效的、选择性的 MAPKAPK2(MK2) 抑制剂 (IC50=0.11 uM)，具有非 ATP 竞争性结合模式。
  40. GC61819 MK2-IN-3 MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM.
  41. GC72100 MK2-IN-5 acetate MK2-IN-5 acetate为Mk2假衬底(Ki= 8 μM)。
  42. GC18156 MK8353

    SCH900353

     MK8353 (SCH900353) 是一种有效的、选择性的、可口服的 ERK1/2 抑制剂，IC50 分别为 23.0 nM 和 8.8 nM； MK8353 具有抗肿瘤活性。
  43. GC62315 MKK7-COV-9 MKK7-COV-9 是一种有效的、选择性的 MKK7 共价抑制剂，靶向 MKK7 的一种特异性蛋白-蛋白相互作用。MKK7-COV-9 阻断了原代 B 细胞应对 LPS 的激活的 EC50 值为 4.98 μM.
  44. GC15296 ML 786 dihydrochloride Raf kinase inhibitor
  45. GC11307 ML-264

    (2E)-3-(3-氯苯基)-N-[2-[甲基(四氢-1,1-二氧代-2H-噻喃-4-基)氨基]-2-氧代乙基]-2-丙烯酰胺

     A selective KLF5 inhibitor
  46. GC64634 MLK-IN-1 MLK-IN-1 是一种强效的脑渗透特异性 MLK-3 抑制剂，从专利 US20140256733A1 中获得的化合物 68。
  47. GC63680 MLKL-IN-2 MLKL-IN-2 是一种 MLKL 的抑制剂，详细信息请参考专利文献 WO2021224505A1 中的化合物 (i)。
  48. GC11649 MLN 2480

    6-氨基-5-氯-N-[(1R)-1-[5-[[[5-氯-4-(三氟甲基)-2-吡啶基]氨基]羰基]-2-噻唑基]乙基]-4-嘧啶甲酰胺,BIIB024, BIIB 024, BIIB-024, MLN2480, MLN 2480, MLN-2480

     An oral pan-Raf kinase inhibitor
  49. GC64580 MMI-0100 MMI-0100 是一种细胞渗透性肽抑制剂，抑制丝裂原活化蛋白激酶活化蛋白激酶 II (MK2)。MMI-0100 在体内外减少内膜增生。MMI-0100 抑制 IL-6 表达而不影响 IL-8 表达。MMI-0100 抑制纤维化过程，例如静脉移植疾病。
  50. GC70832 MNK1/2-IN-5 MNK1/2-IN-5是一种强效且选择性的MNK1/2抑制剂，作为治疗剂。
  51. GC48469 Moexipril-d5 An internal standard for the quantification of moexipril

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