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Endocrinology and Hormones

Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

研究方向

Endocrinology and Hormones 相关产品(940)

  • GC36465 structure
    GC36465Liothyronine
    CAS: 6893-02-3
    纯度: >98.00%

    An thyroid hormone which binds to TRβ1, and activates its activity

  • GC36479 structure
    GC36479Loperamide hydrochloride
    CAS: 34552-83-5
    纯度: >99.50%

    An Analytical Reference Standard

  • GC36487 structure
    GC36487L-Thyroxine sodium salt pentahydrate
    CAS: 6106-07-6
    纯度: >98.00%

    A synthetic form of thyroxine

  • GC36499 structure
    GC36499LXRβ agonist-2
    CAS: 1949801-52-8

    LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂，EC50为 7 nM，其选择性是 LXRα (EC50=200 nM) 的 28.5 倍，用于治疗动脉粥样硬化。

  • GC36508 structure
    GC36508LY-2940094
    CAS: 1307245-86-8
    纯度: >99.50%

    LY-2940094 是一种口服有效的选择性 nociceptin 受体 (NOP 受体) 拮抗剂，对 NOP 受体具有高亲和力(Ki 为 0.105 nM) 和拮抗活力 (Kb=0.166 nM)。LY-2940094 可降低动物模型的自身给药酒精依赖。

  • GC36562 structure
    GC36562MCOPPB triHydrochloride
    CAS: 1108147-88-1
    纯度: >99.50%

    MCOPPB 3Hcl 是一种伤害感受肽受体激动剂，pKi为10.07；其他阿片受体的活性较弱。

  • GC36621 structure
    GC36621MK-0773
    CAS: 606101-58-0
    纯度: >98.00%

    MK-0773 是一种选择性雄激素受体调节剂 (selective androgen receptor modulators)，与 AR 结合，IC50 值为 6.6 nM。

  • GC36689 structure
    GC36689Nalfurafine hydrochloride
    CAS: 152658-17-8
    纯度: >99.50%

    An Analytical Reference Standard

  • GC36778 structure
    GC36778N-terminally acetylated Leu-enkephalin
    CAS: 2703746-32-9

    N-terminally acetylated Leu-enkephalin 是N-末端乙酰化的 Leu-enkephalin。Leu-enkephalin是一种五氨基酸的内源性肽，作为阿片受体的激动剂。

  • GC36820 structure
    GC36820Ostarine
    CAS: 841205-47-8

    Ostarine (GTx-024, MK-2866, Enobosarm) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.

  • GC36947 structure
    GC36947Porcine dynorphin A(1-13)
    CAS: 72957-38-1
    纯度: >98.50%

    Porcine dynorphin A (1-13) 是一个有效的内源性阿片受体 (κ opioid receptor) 激动剂，在生理浓度下它有镇痛作用。

  • GC36981 structure
    GC36981PROTAC AR Degrader-4
    CAS: 1351169-31-7

    PROTAC AR Degrader-4 包含 cIAP1 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。

  • GC37525 structure
    GC37525RGX-104 free Acid
    CAS: 610318-54-2
    纯度: >99.50%

    RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂，通过ApoE基因的转录激活调节先天免疫。

  • GC37630 structure
    GC37630Sevelamer
    CAS: 52757-95-6

    Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

  • GC37687 structure
    GC37687Stanolone benzoate
    CAS: 1057-07-4
    纯度: >99.50%

    Stanolone benzoate (Androstanolone benzoate) 是一种合成的雄激素和合成代谢类固醇。

  • GC37691 structure
    GC37691Stigmasterol glucoside
    CAS: 19716-26-8

    Stigmasterol glucoside 是从 P. urinaria 分离出的一种甾醇，具有高抗氧化和高抗炎活性，能作为抑制剂 5α-reductase 的抑制剂，IC50 值为 27.2 ?M。

  • GC37732 structure
    GC37732Taltirelin acetate
    CAS: 1549593-23-8
    纯度: >98.50%

    Taltirelin acetate (TA-0910 acetate) 是一种促甲状腺激素释放激素受体 (TRH-R) 超激动剂，IC50 值为 910 nM，刺激细胞溶质Ca2+ 浓度增加 (Ca2+ 释放) 的 EC50 值为 36 nM。

  • GC37829 structure
    GC37829Trimebutine maleate
    CAS: 34140-59-5
    纯度: >98.00%

    An opioid receptor agonist

  • GC38005 structure
    GC38005β-Endorphin, equine
    CAS: 79495-86-6

    β-Endorphin, equine 为具有镇痛作用的内源性阿片类多肽。

  • GC38030 structure
    GC38030β-Endorphin, equine (TFA)

    β-Endorphin, equine (TFA) 是一种内源性阿片类多肽，对 μ 和 δ 阿片受体 (μ/δ opioid receptors) 有很强的亲和性。具有止痛作用。

  • GC38581 structure
    GC38581Abaloparatide TFA

    Abaloparatide TFA (BA 058 TFA) 是一种甲状旁腺激素受体 1 PTHR1 类似物，是 PTHR1 信号通路的有效和选择性激活剂。Abaloparatide TFA 增强 MC3T3-E1 成骨细胞的 Gs/cAMP 信号传导 (EC50 为 0.3 nM) 和 β-arrestin 的募集 (EC50 为 0.9 nM)。

  • GC38682 structure
    GC38682Flavanone
    CAS: 487-26-3
    纯度: >98.00%

    Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties.

  • GC38741 structure
    GC38741BPR1M97
    CAS: 2059904-66-2
    纯度: >98.50%

    BPR1M97具有双重活性的μ阿片受体（MOP）和孤啡肽FQ肽（NOP）受体激动剂。

  • GC38842 structure
    GC38842Ro 64-6198
    CAS: 280783-56-4
    纯度: >98.00%

    Ro 64-6198 是一种有效的，选择性的，非肽，高亲和力，高细胞通透性和脑渗透 N/OFQ 受体 (NOP) 激动剂，EC50 值为 25.6 nM。Ro 64-6198 对 NOP 受体的选择性至少是经典阿片受体的 100 倍。Ro 64-6198 可用于治疗压力和焦虑，成瘾，神经性疼痛，咳嗽和厌食症。