GlpBio

Nalfurafine hydrochloride

目录号: GC36689纯度: >99.50%同义词: 盐酸纳呋拉啡; TRK-820 hydrochloride
An Analytical Reference Standard
Nalfurafine hydrochloride
Cas No.: 152658-17-8
规格价格库存数量操作
2mg¥2,160.00现货
1
5mg¥3,240.00现货
1
10mg¥5,850.00现货
1
50mg¥16,200.00现货
1
100mg¥0.01现货
1
200mg¥0.01现货
1
10mM (in 1mL DMSO)¥3,657.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Nalfurafine (hydrochloride) is an analytical reference standard categorized as an opioid.1 Naflurafine decreases ethanol consumption in male mice and increases ethanol consumption in female mice.2 It is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

1.Watanabe, Y., Kitazawa, S., Fujii, H., et al.Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeletonBioorg. Med. Chem. Lett.24(21)4980-4983(2014) 2.French, A.R., Gutridge, A.M., Yuan, J., et al.Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumptionPharmacol. Biochem. Behav.216173377(2022)

实验参考方法 Experimental Reference Method

Animal experiment:

Rats: Nalfurafine is given to male Sprague-Dawley rats at volume of 1 mL/kg. After collecting control samples for 80 min, PCP (10 mg/kg, i.p.) is administered to the rats, and then the collection of dialysate is continued for 180 min. Pre-treatment with TRK-820 or vehicle is performed subcutaneously 5 min before the administration of PCP. Dopamine and serotonin levels in the dialysate are quantified by high-performance liquid chromatography[2]. Mice: Chronic dry skin on the nape of the neck is induced on the C57BL/6 mice. Nalfurafine (20 μg/kg) or saline is administered. Then alloknesis testing is conducted[1].

References:

[1]. Akiyama T, et al. Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice. Acta Derm Venereol. 2015 Feb;95(2):147-50.
[2]. Ikeda K, et al. TRK-820, a selective kappa opioid receptor agonist, could effectively ameliorate L-DOPA-induced dyskinesia symptoms in a rat model of Parkinson's disease. Eur J Pharmacol. 2009 Oct 12;620(1-3):42-8.
[3]. Yoshikawa S, et al. Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models. Eur J Pharmacol. 2009 Mar 15;606(1-3):102-8.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
152658-17-8
同义词
盐酸纳呋拉啡; TRK-820 hydrochloride
SMILES
O[C@@]1(CC[C@@H](N(C)C(/C=C/C2=COC=C2)=O)[C@]3([H])OC4=C5O)[C@]63C4=C(C=C5)C[C@@]1([H])N(CC7CC7)CC6.[H]Cl
分子式
C28H33ClN2O5
分子量
513.03 g/mol
溶解性
DMSO: 33.33 mg/mL (64.97 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol