GlpBio

L-152,804

目录号: GC16987纯度: >99.50%
L-152,804 是一种具有口服活性的选择性神经肽 Y Y5 受体 (NPY5-R) 拮抗剂，对 hY5 的 Ki 值为 26 nM。
L-152,804
Cas No.: 6508-43-6
规格价格库存数量操作
5mg¥810.00现货
1
10mg¥1,350.00现货
1
50mg¥3,420.00现货
1
100mg¥4,950.00现货
1
10mM (in 1mL DMSO)¥891.00现货
1
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产品描述 Description

L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2].

L 152804 displays > 300-fold selectivity over hY1, hY2, and hY4 receptors[1].

References:
[1]. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.
[2]. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
6508-43-6
化学名
(R)-2-(3,3-dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione
SMILES
O=C(CC(C)(C)CC1=O)C1[C@H]2C3=C(CC(C)(C)CC3=O)OC4=CC=CC=C24
分子式
C23H26O4
分子量
366.46 g/mol
溶解性
<36.65mg/ml in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol